AIDS Clinical Trials Group Study 094: a phase I/II trial of ABV chemotherapy with zidovudine and recombinant human GM-CSF in AIDS-related Kaposi''s sarcoma

The aim of this study was to evaluate psychosocial quality of life after heart transplantation. We examined 29 patients (25 M and 4 F), average age was 43.5 y (18-62 y). The age at time of heart transplantation was 43 years (17-55 y). The time after heart transplantation was 3.3 year (0.3-9 y). Spielberger's Questionnaire of Anxiety, Knobloch's inventory of neuroticism, Freiburg's Personality Inventory and Quality of Life Inventory were used, 33% of patients demonstrated increasing frequency and 29% of patients increasing intensity of neurotic symptoms. 23% of patients presented increasing levels of anxiety (as a state). The personality dimensions (depression, excitability and low emotional stability) displayed high frequency. The results showed that patients were more satisfied with family support, with sexual activities, and less satisfied with financial situation, social activities, social isolations, sleep, memory, excitability, fatigue. 41.5% of patients returned back to work. The results indicate that these psychosocial factors play an important role in quality of life after heart transplantation. That is why if is necessary to dedicate an increasing attention to them. (Tab. 1, Fig. 6, Ref. 14.)     

基于结构可拓模型的产品结构方案再设计方法

针对产品结构设计要素之间存在非功能作用且作用关系形式不统一、不易识别、表达拓展性差等问题,提出了基于结构可拓模型的产品结构方案再设计方法。考虑非功能作用与结构的关联关系,基于可拓理论提出产品结构基元概念,即实体元、交互元、可供性元,并基于此构建产品结构可拓模型,用于表达产品结构设计要素及作用关系。借助需求—可供性—交互关系—结构多个设计域映射机制,通过需求—可供性映射挖掘产品待改进可供性,通过可供性—交互关系—结构映射确定产品待改进结构。对可供性元进行拓展分析得到产品可行结构方案集。采用优度评价法选取最优结构方案。给出结构可拓变换规则,实现产品结构再设计方案。最后以跟腱康复装置再设计为例,验证了所提出方法的可行性和有效性。