How can we best use landmarks to support older people in navigation?

Although landmarks are an integral part of navigation, they have rarely been used explicitly within electronic pedestrian navigation aids. We describe a two-part study into the use of landmarks in such aids, using a set of field experiments. The first part investigated whether such devices can be effective for older adults (over 60 years old), who might particularly benefit from them due to declines in sensory, cognitive and motor abilities. The second part compared the effectiveness of different methods of presenting landmark information. We show that a pedestrian navigation aid based around landmarks is particularly useful for older people and demonstrate that text, speech and photographs are all effective ways of presenting landmark information, although speech on its own has some drawbacks. We found that different people prefer information to be presented in different modalities, indicating a need for personalisation, although multi-modality may also help to address this issue.     

基于Heritrix与Lucene的垂直搜索引擎研究

垂直搜索是针对某一个行业的专业搜索引擎,是搜索引擎的细分和延伸,是对网页库中的某类专门的信息进行一次整合,定向分字段抽取出需要的数据进行处理后再以某种形式返回给用户。该文结合使用Heritrix与Lucene对学校新闻网站网页进行抓取并建立索引,建立相对应的新闻垂直搜索引擎系统。     

An aide for instruction on integrated engineering design and support

Effective management of engineering information is critically needed for the design of future complex engineering systems. Yet engineers are not trained in engineering data base management concepts. To help address this issue, a prototype integrated design system has been developed for the Air Force to aide research and instruction on key integration concepts, including (1) the use of a shared data base to eliminate redundancies and inconsistencies; (2) the use of a relational data base management system to store, locate, and retrieve data from the shared data base; (3) the development of interfacing programs to act as interpreters between the application programs and the common data base; and (4) the role of executive software to manage the integrated system. Key software used includes a computer-aided design system, a structural analysis program, various graphics packages, and a relational data base management system. To assess system flexibility, additional programs were added to the system. The design of the data base proved to be an important step in this implementation. Several methodologies useful in the design of the data base were investigated and subsequently used to organize the data base for the integrated design system. Results discussed include system development, and applications, as well as the effectiveness of the integrated system's configuration.     

Estrogen receptor domains E and F: role in dimerization and interaction with coactivator RIP-140

We have used the yeast two-hybrid system to localize the ligand-dependent dimerization domain of the estrogen receptor-alpha (ER) to region E in vivo. In this system, the cDNAs corresponding to the A-D, E, E/F, A-E (deltaF), and full-length (wtER) domains of the human ER were each cloned into the yeast two-hybrid vectors GAL4 DB and GAL4 TA and expressed in different combinations in yeast harboring a GAL1-lacZ reporter. The reporter was used as a relative measure of the interaction between the ER domains, through reconstitution of GAL4 activity. We found that the interaction of E or E/F domains of the ER with full-length ER is estradiol dependent and estrogen responsive element independent, as measured by the reconstitution of GAL4 activity from GAL4-E domain-containing fusion protein interactions. In the presence of F domain, this activity is reduced 10-fold. The results suggest that sequences in the F domain are inhibitory to the dimerization signal that is present in the E region. We propose that the full-length ER contains intrinsic dimerization restraints contributed by regions outside domain E that are released upon binding hormone agonist. In addition, we have demonstrated that coactivator RIP140 is able to interact with the ER in vivo at the E domain of the receptor in the presence of estrogen. Yeast two-hybrid analysis shows that RIP140 does not homodimerize in the presence or absence of estrogens. We present evidence showing that the ER has the inherent ability to interact with RIP140 in the presence of antiestrogens, but sequences inherent in the ER itself that are present outside of the E domain compromise this ability.     

Molecular cloning of mouse glycolate oxidase. High evolutionary conservation and presence of an iron-responsive element-like sequence in the mRNA

Iron regulatory proteins (IRPs) control the synthesis of several proteins in iron metabolism by binding to iron-responsive elements (IREs), a hairpin structure in the untranslated region (UTR) of corresponding mRNAs. Binding of IRPs to IREs in the 5' UTR inhibits translation of ferritin heavy and light chain, erythroid aminolevulinic acid synthase, mitochondrial aconitase, and Drosophila succinate dehydrogenase b, whereas IRP binding to IREs in the 3' UTR of transferrin receptor mRNA prolongs mRNA half-life. To identify new targets of IRPs, we devised a method to enrich IRE-containing mRNAs by using recombinant IRP-1 as an affinity matrix. A cDNA library established from enriched mRNA was screened by an RNA-protein band shift assay. This revealed a novel IRE-like sequence in the 3' UTR of a liver-specific mouse mRNA. The newly identified cDNA codes for a protein with high homology to plant glycolate oxidase (GOX). Recombinant protein expressed in bacteria displayed enzymatic GOX activity. Therefore, this cDNA represents the first vertebrate GOX homologue. The IRE-like sequence in mouse GOX exhibited strong binding to IRPs at room temperature. However, it differs from functional IREs by a mismatch in the middle of its upper stem and did not confer iron-dependent regulation in cells.     

模拟裂变中子源能谱测量

一、引言在研究链式反应系统的各种性质时,常常用到具有类似裂变中子能谱的中子源。模拟裂变中子源主要由~(210)Po的α粒子轰击F,Be,Li,B等轻元素产生中子,随着靶元素成份以及结构的差异,中子能谱也不完全相同。应本院同位素处的要求,我们测量了一模拟裂变中子源的能谱,其源强约10~4n/s,靶成份为天然Li 24.16%,F66.14%,B 9.4%,     

Kawaihiko and the third-quartile day [traffic management]

The Kawaihiko network, linking the New Zealand universities to the Internet, pioneered traffic measurement as a tool for network management and cost recovery. Its history and its use of the real-time traffic flow measurement architecture to measure its traffic are described. The Kawaihiko members wanted a “measured bandwidth” metric which would be a good indicator of the bandwidth required to carry each site's traffic. Kawaihiko developed such a metric-the third-quartile day-based on a daily usage profile or third-quartile profile. The 3QP and 3QD are described in detail, and illustrated with typical plots from several of the Kawaihiko sites. The Kawaihiko members found 3QD to be an effective bandwidth measure, and 3QP a useful traffic management tool     

No interactive effects of naltrexone and benzodiazepines on pain during phobic fear

Animal research has shown that anxiety may inhibit pain through the release of endogenous opioids. On the other hand, anxiety is often believed to exacerbate pain in clinical situations, and anxiety reduction has been shown to attenuate the affective component of pain. In the present study phobic anxiety was induced by confronting forty-eight spider phobic subjects with a spider, after which they received two mildly painful electrical stimuli at two different current levels. The benzodiazepine alprazolam (1 mg) was administered to investigate the influence on pain of a reduction in anxiety, while the role of endogenous opioids was studied by administering the opioid antagonist naltrexone (50 mg). Alprazolam resulted in lower anxiety and pain ratings during pain stimulation, supporting the idea that (presumably pain-related) anxiety may increase the experience of pain. Naltrexone did not influence pain and anxiety ratings, nor was there a significant interaction between the two pharmacological manipulations. These findings confirm previous evidence that phobic fear does not necessarily induce an endogenous opioid-mediated analgesia.