Treatment of vulvovaginal candidiasis in pregnancy. A comparative study

A carefully controlled comparative study showed miconazole nitrate 2% vaginal cream (Monistat) to be a highly effective agent in the treatment of vaginal candidiasis in pregnant subjects. Miconazole nitrate was significantly more effective than nystatin (Mycostatin) in the treatment of vaginal candidiasis in all three trimesters of pregnancy, and also more effective regardless of whether the candidal infection was primary or recurrent. Observations relating to the safety of this therapy during pregnancy were made and discussed.     

中国天然气勘探开发现状及物探技术需求

2000年以来,中国石油天然气集团公司在鄂尔多斯盆地、四川盆地、塔里木盆地、松辽盆地、柴达木盆地、渤海湾盆地等的天然气勘探中不断获得新的发现,初步形成了东部、中部、西部协调发展的合理布局。现阶段面临的问题是如何尽快将资源优势转化为经济优势。目前,我国天然气主要储集层为碎屑岩、碳酸盐岩和火山岩三大岩石类型。碎屑岩储层特征表现为我国中部丘陵地区的低孔、低渗的致密砂岩以及西部复杂高陡构造的孔隙砂岩;碳酸盐岩和火山岩储层普遍埋藏较深,非均质性强,缝洞单元难以刻画。因此,必须采用有针对性的地球物理勘探技术,优先发展碎屑岩气藏检测勘探技术,强化地震岩石物理等基础研究,加快碳酸盐岩、火山岩气藏检测技术攻关。同时开展高密度、多波地震勘探等前沿技术研究,为定量评价和产能建设提供技术保障。     

提高储层预测精度技术思路与对策

采用地质、地震、测井人员协同一体化作业,对地下地质目标进行综合预测与评价,可提高储层预测精度,降低预测结果的多解性。主要方法是针对不同的区块,采用不同的方法和对策,首先从单井储层划分对比入手,建立储层沉积模式,同时对地震数据目的层段进行精细解释,建立地层构造模式,用沉积、构造等地质规律来指导和约束反演;利用测井资料对地震资料进行精细标定,建立各井的单井波阻抗模型,建立井数据和地震数据沟通的桥梁;在严格的测井约束、地质模型约束、层位控制下进行储层反演;充分利用地质、地震反演结果、地震参数提取及分析结果、测井、测试和分析化验等资料对储层预测结果进行综合分析与评价。该方法应用于长庆、大庆、准噶尔等实际区块,取得了较好的效果。     

No interactive effects of naltrexone and benzodiazepines on pain during phobic fear

Animal research has shown that anxiety may inhibit pain through the release of endogenous opioids. On the other hand, anxiety is often believed to exacerbate pain in clinical situations, and anxiety reduction has been shown to attenuate the affective component of pain. In the present study phobic anxiety was induced by confronting forty-eight spider phobic subjects with a spider, after which they received two mildly painful electrical stimuli at two different current levels. The benzodiazepine alprazolam (1 mg) was administered to investigate the influence on pain of a reduction in anxiety, while the role of endogenous opioids was studied by administering the opioid antagonist naltrexone (50 mg). Alprazolam resulted in lower anxiety and pain ratings during pain stimulation, supporting the idea that (presumably pain-related) anxiety may increase the experience of pain. Naltrexone did not influence pain and anxiety ratings, nor was there a significant interaction between the two pharmacological manipulations. These findings confirm previous evidence that phobic fear does not necessarily induce an endogenous opioid-mediated analgesia.