处理工艺对复合芝麻酱体系稳定性的影响

目的:研究复合芝麻酱在不同处理工艺条件下体系的稳定性。方法:考察加热温度、搅拌时间、冷却工序、灌装温度及静置熟化工序对复合芝麻酱离心析油率的影响,并记录47℃保温条件下复合芝麻酱的析油时间。结果:复合芝麻酱的最佳处理工艺为加热温度55℃,搅拌时间20 min, 0℃冷却降温,灌装温度40℃,静置熟化24 h。此工艺条件下制备的复合芝麻酱的离心析油率由初始的6.69%显著降低至1.78%(P<0.05),且其微观结构油相分布均匀并形成了紧密的联结区。结论:复合芝麻酱工艺参数的优化能显著改善体系的析油问题,最优工艺条件下加工的复合芝麻酱的体系稳定性最佳。     

Substituted glycals as probes of glycosidase mechanisms

D-Glucal and a series of substituted derivatives have been tested as substrates, inhibitors and inactivators of the Agrobacterium faecalis beta-glucosidase in order to probe structure/function relationships in this enzyme. D-Glucal is shown to be a substrate (kcat = 2.3 min-1, Km = 0.85 mM) undergoing hydration with stereospecific protonation from the alpha-face to yield 2-deoxy-beta-D-glucose. 1-Methyl-D-glucal surprisingly serves as only a poor substrate (kcat = 0.056 min-1, Km = 57 mM), also undergoing protonation from the alpha-face. 2-Fluoro-D-glucal, however is completely inert, as a result of inductive destabilisation of the oxocarbenium ion-like transition state for protonation, and functions only as a relatively weak (Ki = 24 mM) inhibitor. Similar behaviour was seen with almond beta-glucosidase and yeast alpha-glucosidase and for the interaction of 2-fluoro-D-galactal with Escherichia coli beta-galactosidase. A series of of alpha, beta-unsaturated glucal derivatives was also synthesised and tested as potential substrates, inhibitors or inactivators of A. faecalis beta-glucosidase. Of these only 1-nitro-D-glucal functioned as a time dependent, irreversible inactivator (ki = 0.011 min-1, Ki = 5.5 mM), presumably acting as a Michael acceptor. Electrospray mass spectrometric analysis revealed multiple labeling of the enzyme by this inactivator, lessening its usefulness as an affinity label. Less reactive Michael acceptor glycals which might have been more specific (1-cyano-, 2-cyano-, 1-carboxylic acid, 1-carboxylic acid methyl ester) unfortunately did not function as inactivators or substrates, only as relatively weak reversible inhibitors (Ki = 3-96 mM).     

Improvement of some pharmaceutical properties of drugs by cyclodextrin complexation. 4. Chlorpromazine hydrochloride

This study is a retrospective review of admissions, discharge records and blood culture results of neonates admitted to the Neonatal Intensive Care Unit of Korle Bu Teaching Hospital in Accra, from the first of January 1991 to the 31st of December 1992. During this two year period there were 443 positive blood cultures. Ninety percent of the blood cultures were from babies born in Korle Bu Teaching Hospital, thus making the incidence of neonatal bacteraemia 22.2 per 1000 live births. The overall mortality rate was 37.2%. Gram negative bacteria accounted for 70.9% and Gram positive bacteria for 29.1% of all neonatal bacteraemia. The most common isolates were Enterobacter species 29.6%; Streptococcus faecalis 14.4%; Staphylococcus aureus 10.8%; Acinetobacter species 9.5%; Klebsiella species 9% and Escherichia coli 8.8%. It is concluded that the incidence of neonatal bacterial sepsis is high in our hospital and is associated with a very high mortality rate. There is thus an urgent need to institute appropriate preventive and therapeutic measures.     

Reductions in self-injury produced by transcutaneous electrical nerve stimulation

Transcutaneous electrical nerve stimulation is used to reduce pain but also may be useful for self-injurious behavior (SIB). In the current investigation, a microcurrent electromedical device, classified as a transcutaneous electrical nerve stimulator (TENS), was applied with a man with Down syndrome who displayed SIB that persisted in the absence of social contingencies. Although clinically significant results were not maintained, a clear difference in the rates of SIB during active and inactive TENS was observed.     

芳纶纤维在轮胎工业中的应用

笔者主要介绍了芳纶纤维(包括长纤维和短纤维)的性能及其在轮胎工业的应用，同时简要叙述了芳纶纤维的分类和发展历史。     

An analysis of simultaneous variation in protein structures

The simultaneous substitution of pairs of buried amino acid side chains during divergent evolution has been examined in a set of protein families with known crystal structures. A weak signal is found that shows that amino acid pairs near in space in the folded structure preferentially undergo substitution in a compensatory way. Three different physicochemical types of covariation 'signals' were then examined separately, with consideration given to the evolutionary distance at which different types of compensation occur. Where the compensatory covariation tends towards retaining the combined residue volumes, the signal is significant only at very low evolutionary distances. Where the covariation compensates for changes in the hydrogen bonding, the signal is strongest at intermediate evolutionary distances. Covariations that compensate for charge variations appeared with equal strength at all the evolutionary distances examined. A recipe is suggested for using the weak covariation signal to assemble the predicted secondary structural elements, where the evolutionary distance, covariation type and weighting are considered together with the tertiary structural context (interior or surface) of the residues being examined.      

芳纶橡胶输送带的接头强度研究

针对芳纶橡胶输送带接头强度保持率低的问题,本研究以国内外芳纶橡胶输送带接头方案为基础,采用指型插接方案,系统性地探究了指型长径比、贴胶厚度、织物增强层结构等因素对接头强度的影响。实验证明接头强度随长径比的增大而升高;贴胶厚度在1mm时接头强度达到最大,此后接头强度随贴胶厚度的增加而降低;织物增强层沿经向放置的接头强度提高87%,接头强度保持率达到带体强度的60%。     

节能型活性染料的发展状况

综述了开发节能型活性染料的重要性.重点介绍了适用于冷轧堆染色、小浴比染色和涤/棉一浴法染色用活性染料以及高固色率活性染料的发展状况;通过提高染料的耐碱性、溶解度、染深性以及固着率等方面来达到节能减排的目的.