Diabetic ketoacidosis and rhabdomyolysis following excessive intake of a weight reducing diet

We describe two unusual cases in sheep of subclinical mastitis caused by Streptococcus parasanguinis. This bacterium has been associated with the development of experimental endocarditis; its presence at relatively high concentrations in apparently healthy sheep milk may pose a health risk in persons with predisposing heart lesions.     

The Australian brushtail possum (Trichosurus vulpecula) gonadotrophin alpha-subunit: analysis of cDNA sequence and pattern of expression

Substantial evidence has accumulated to suggest that in the near future implementation of the veto-cell-suppressor concept in the treatment of kidney allograft recipients might lead to the establishment of life-long specific allograft tolerance in the absence of further immunosuppressive therapy. Veto suppression prevents the generation of antigen-specific T-helper and cytotoxic T lymphocytes in vitro provided that the T-lymphocyte precursors specifically recognize antigenic peptides associated with the major histocompatibility complex molecules class II and class I, respectively, expressed on the surface of the veto-active cell. Data from a large number of experimental and clinical studies strongly indicate that veto-active cells function in vivo and are capable of preventing allograft rejection. Thus, donor-cell-mediated veto activity is the most likely explanation for the well-known graft tolerizing effect of pretransplant donor blood transfusions in kidney graft recipients. A prerequisite for a veto-active environment in vivo is the establishment of lymphoid microchimerism, in which veto-active donor and recipient cells mutually downregulate potential alloaggression.     

In vivo labelling of the mouse brain 5-hydroxytryptamine1A receptor with the novel selective antagonist 3H-NAD-299

The in vivo labelling of 5-hydroxytryptamine (5-HT)1A receptors in the mouse brain was studied with the novel selective 5-HT1A receptor antagonist, NAD-299 ((R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran- 5-carboxamide hydrogen (2R,3R)-tartrate monohydrate). 3H-NAD-299 was injected in a tail vein and the radioactivity in various brain regions was determined. More than 90% of the radioactivity in hippocampus, 15 min after the injection, was intact NAD-299. At this time the amount of 3H-NAD-299 was highest in hippocampus followed by frontal cortex, mesencephalon, hypothalamus, striatum and cerebellum. The specific accumulation of radioactivity (after subtracting cerebellum values) in frontal cortex and hippocampus was maximal 10 to 30 min after the injection and had almost disappeared after 2 h. Saturation kinetics derived Bmax (pmol/g wet weight tissue) values of 19.6+/-2.0 in frontal cortex and 38.0+/-3.5 in hippocampus. The apparent Kd values expressed in nmol/kg 3H-NAD-299 injected, were 12.3+/-2.2 in frontal cortex and 20.3+/-3.1 in hippocampus. The 5-HT1A receptor antagonist, WAY-100,635 competitively inhibited the specific accumulation of 3H-NAD-299 and was about equipotent with unlabelled NAD-299 with ED50 values of 20-30 nmol/kg s.c. These compounds were about 10 times more potent than the 5-HT1A receptor antagonists, p-MPPI and NDL-249 and 100 times more potent than (S)-UH-301. 5-HT1A receptor agonists, e.g. 8-OH-DPAT and flesinoxan and partial agonists, e.g. pindolol, buspirone and ipsapirone had low potency in this in vivo assay. Spiperone and methiothepin inhibited the 3H-NAD-299 accumulation at 10 micromol/kg s.c. The alpha1-adrenoceptor antagonist, prazosin at 2 micromol/kg s.c. increased significantly the specific accumulation of 3H-NAD-299. Pretreatment of the mice with the non-selective, irreversible receptor antagonist, EEDQ produced a dose related long-lasting decrease in the accumulation of 3H-NAD-299. It is concluded that NAD-299 is a very suitable ligand for studies of 5-HT1A receptors in the brain in vivo.     

The exotoxin of Bacillus thuringiensis: a new C-mitotic agent

Thuringiensin A, an exotoxin from Bacillus thuringiensis, a constituent of the microbial insectide thuricide has been found to inhibit mitotic spindle, condense and scatter chromosomes. It may therefore be a promizing tool in future cell biological studies.     

System for production of high and low protein dispersibility index edible extracted soybean flakes

A standard flash desolventizing system has been combined with horizontal agitated meal stripping and cooking vessels operating at atmospheric pressure to provide an integrated system for the production of high, intermediate, or low protein dispersability index edible soybean flakes from extracted solvent-wet flakes. Flash desolventizing removes most of the hexane in the wet flakes by evaporation at low temperature in a turbulent stream of superheated hexane vapor. The small remaining hexane quantity is removed in a stripping process capable of producing the full range of protein dispersability index values in the flakes by treating the flash desolventized flakes with either dry superheated steam or wet saturated steam under carefully controlled conditions of steam temperature, pressure, flow rate, and moisture content. The products are light colored, with little production of fine particles. One of seven papers presented at the symposium “Processing Methods for Oilseeds,” AOCS Spring Meeting, April 1973.     

A compact, low profile, transmission line antenna--Tunable over greater than octave bandwidth

Techniques for extending the frequency tuning range of low profile top loaded antennas to greater than one octave are described. The compact antenna is a directly driven resonant radiator (DDRR) which consists of a vertical post radiator, the height of which is less than0.05lambdaat the highest operating frequency, and which is top loaded by a loosely spiraled unbalanced transmission line which employs a multiple-capacitor tuning scheme to achieve a wide-band, tunable resonant antenna. The measured antenna circuitQis of the order of 100 or greater and the radiation efficiency, over a large ground plane, is greater than 50 percent that of a quarter-wave monopole over the full operating range.     

Sexual variables and shock-elicited aggression.

Investigated the relationship between sex and the amount of shock-elicited aggression (SEA) in 4 experiments. Results show that (a) Sprague-Dawley males (n = 48) had higher SEA frequencies than females (n = 48), but this difference was not statistically significant; (b) Long-Evans males (n = 32) exhibited higher SEA frequencies than females (n = 32); (c) sham-operated Sprague-Dawley males (n = 35) showed higher SEA frequencies than castrated males (n = 35) but this difference was diminished by testosterone replacement in the castrated group; and (d) SEA was unrelated to free-field or stabilometer activity measurement (n = 40 male Sprague-Dawley rats). Considerable aggression occurred in all Ss, suggesting that although sexual variables affect SEA, they do not play as important a role as in other kinds of aggression. (28 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)