全文获取类型
收费全文 | 1497篇 |
免费 | 1篇 |
专业分类
化学工业 | 4篇 |
建筑科学 | 1篇 |
轻工业 | 3篇 |
一般工业技术 | 7篇 |
冶金工业 | 1481篇 |
自动化技术 | 2篇 |
出版年
2015年 | 1篇 |
2013年 | 3篇 |
2012年 | 1篇 |
2010年 | 1篇 |
2007年 | 1篇 |
2006年 | 3篇 |
2003年 | 4篇 |
2002年 | 1篇 |
2000年 | 1篇 |
1999年 | 35篇 |
1998年 | 468篇 |
1997年 | 277篇 |
1996年 | 179篇 |
1995年 | 91篇 |
1994年 | 72篇 |
1993年 | 84篇 |
1992年 | 7篇 |
1991年 | 23篇 |
1990年 | 18篇 |
1989年 | 17篇 |
1988年 | 16篇 |
1987年 | 26篇 |
1986年 | 16篇 |
1985年 | 13篇 |
1982年 | 8篇 |
1981年 | 14篇 |
1980年 | 11篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 24篇 |
1976年 | 75篇 |
1975年 | 1篇 |
1972年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有1498条查询结果,搜索用时 9 毫秒
61.
AE Fidler SB Lawrence DM Vanmontfort DJ Tisdall KP McNatty 《Canadian Metallurgical Quarterly》1998,20(3):345-353
Substantial evidence has accumulated to suggest that in the near future implementation of the veto-cell-suppressor concept in the treatment of kidney allograft recipients might lead to the establishment of life-long specific allograft tolerance in the absence of further immunosuppressive therapy. Veto suppression prevents the generation of antigen-specific T-helper and cytotoxic T lymphocytes in vitro provided that the T-lymphocyte precursors specifically recognize antigenic peptides associated with the major histocompatibility complex molecules class II and class I, respectively, expressed on the surface of the veto-active cell. Data from a large number of experimental and clinical studies strongly indicate that veto-active cells function in vivo and are capable of preventing allograft rejection. Thus, donor-cell-mediated veto activity is the most likely explanation for the well-known graft tolerizing effect of pretransplant donor blood transfusions in kidney graft recipients. A prerequisite for a veto-active environment in vivo is the establishment of lymphoid microchimerism, in which veto-active donor and recipient cells mutually downregulate potential alloaggression. 相似文献
62.
63.
SB Christensen A Guider CJ Forster JG Gleason PE Bender JM Karpinski WE DeWolf MS Barnette DC Underwood DE Griswold LB Cieslinski M Burman S Bochnowicz RR Osborn CD Manning M Grous LM Hillegas JO Bartus MD Ryan DS Eggleston RC Haltiwanger TJ Torphy 《Canadian Metallurgical Quarterly》1998,41(6):821-835
Evaluation of a variety of PDE4 inhibitors in a series of cellular and in vivo assays suggested a strategy to improve the therapeutic index of PDE4 inhibitors by increasing their selectivity for the ability to inhibit PDE4 catalytic activity versus the ability to compete for high affinity [3H]rolipram-binding sites in the central nervous system. Use of this strategy led ultimately to the identification of cis-4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxyl ic acid (1, SB 207499, Ariflo), a potent second-generation inhibitor of PDE4 with a decreased potential for side effects versus the archetypic first generation inhibitor, (R)-rolipram. 相似文献
64.
SB Gelvin 《Canadian Metallurgical Quarterly》1998,16(11):1009-1010
65.
The in vivo labelling of 5-hydroxytryptamine (5-HT)1A receptors in the mouse brain was studied with the novel selective 5-HT1A receptor antagonist, NAD-299 ((R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran- 5-carboxamide hydrogen (2R,3R)-tartrate monohydrate). 3H-NAD-299 was injected in a tail vein and the radioactivity in various brain regions was determined. More than 90% of the radioactivity in hippocampus, 15 min after the injection, was intact NAD-299. At this time the amount of 3H-NAD-299 was highest in hippocampus followed by frontal cortex, mesencephalon, hypothalamus, striatum and cerebellum. The specific accumulation of radioactivity (after subtracting cerebellum values) in frontal cortex and hippocampus was maximal 10 to 30 min after the injection and had almost disappeared after 2 h. Saturation kinetics derived Bmax (pmol/g wet weight tissue) values of 19.6+/-2.0 in frontal cortex and 38.0+/-3.5 in hippocampus. The apparent Kd values expressed in nmol/kg 3H-NAD-299 injected, were 12.3+/-2.2 in frontal cortex and 20.3+/-3.1 in hippocampus. The 5-HT1A receptor antagonist, WAY-100,635 competitively inhibited the specific accumulation of 3H-NAD-299 and was about equipotent with unlabelled NAD-299 with ED50 values of 20-30 nmol/kg s.c. These compounds were about 10 times more potent than the 5-HT1A receptor antagonists, p-MPPI and NDL-249 and 100 times more potent than (S)-UH-301. 5-HT1A receptor agonists, e.g. 8-OH-DPAT and flesinoxan and partial agonists, e.g. pindolol, buspirone and ipsapirone had low potency in this in vivo assay. Spiperone and methiothepin inhibited the 3H-NAD-299 accumulation at 10 micromol/kg s.c. The alpha1-adrenoceptor antagonist, prazosin at 2 micromol/kg s.c. increased significantly the specific accumulation of 3H-NAD-299. Pretreatment of the mice with the non-selective, irreversible receptor antagonist, EEDQ produced a dose related long-lasting decrease in the accumulation of 3H-NAD-299. It is concluded that NAD-299 is a very suitable ligand for studies of 5-HT1A receptors in the brain in vivo. 相似文献
66.
SB Shustov VKh Khavinson TS Shutak BV Romashevski? 《Canadian Metallurgical Quarterly》1998,76(9):45-48
Epithelamine made in Russia (Samson, St. Petersburg) was tried for effects on carbohydrate metabolism and cardiovascular system in 33 patients with non-insulin-dependent diabetes mellitus (NIDDM). Adjuvant use of epithelamine in combined treatment of NIDDM promoted a stable compensation of carbohydrate metabolism, lowering of glycosylated hemoglobin, immunoreactive insulin. There was also a moderate hypotensive effect and improvement of left ventricular diastolic function. 相似文献
67.
68.
69.
JA Hejna PL Johnstone SL Kohler DA Bruun CA Reifsteck SB Olson RE Moses 《Canadian Metallurgical Quarterly》1998,26(4):1124-1125
Bacterial Artificial Chromosomes (BACs) have been used to complement a metabolic defect and to transfer a drug resistance marker into mammalian cells by electroporation. The selectable markers are stable and the recipient cells have BAC DNA integrated into the chromosomes as shown by fluorescent in situ hybridization, PCR and Southern hybridization. 相似文献
70.