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221.
Saxena AP Deepa M Joshi AG Bhandari S Srivastava AK 《ACS applied materials & interfaces》2011,3(4):1115-1126
Nanocomposite assemblies of poly(3,4-ethylenedioxythiophene) (PEDOT), embedded with (a) fluoro alkyl phosphate based ionic liquid functionalized graphene (ILFG) and (b) reduced graphene oxide (RGO) prepared from a modified Hummers' method, have been synthesized. Defect free graphene nanosheets within the size of a few nanometers were achieved in the PEDOT-ILFG nanocomposite. In contrast, structures comprising graphene oxide wrinkles interspersed with the amorphous polymer were obtained in the PEDOT-RGO nanocomposite. X-ray photoelectron spectroscopy showed that neat ILFG was considerably less oxidized as compared to the neat RGO, which ratified the superiority of the ionic liquid functionalization strategy over the conventional chemical approach, for exfoliating graphite. Substantially higher electrochemical activity, improved ionic/electronic conductivity, much faster switching rates, and an almost ballistic enhancement in the electrochromic coloration efficiency attained for the PEDOT-ILFG nanocomposite in comparison to PEDOT-RGO film were irrefutable proofs that demonstrated the ability of the ionic liquid to not only fortify the structure of graphene but also facilitate charge transport through the bulk of the film, by providing less impeded pathways. Since PEDOT-ILFG/-RGO nanocomposites of good uniformity have been achieved, this, to some extent, addresses the challenge associated with the processing of graphene based high performance materials for practical applications. 相似文献
222.
Xiaoyu Che Christopher R. Brydges Yuanzhi Yu Adam Price Shreyas Joshi Ayan Roy Bohyun Lee Dinesh K. Barupal Aaron Cheng Dana March Palmer Susan Levine Daniel L. Peterson Suzanne D. Vernon Lucinda Bateman Mady Hornig Jose G. Montoya Anthony L. Komaroff Oliver Fiehn W. Ian Lipkin 《International journal of molecular sciences》2022,23(14)
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by unexplained physical fatigue, cognitive and sensory dysfunction, sleeping disturbances, orthostatic intolerance, and gastrointestinal problems. People with ME/CFS often report a prodrome consistent with infections. Using regression, Bayesian and enrichment analyses, we conducted targeted and untargeted metabolomic analysis of plasma from 106 ME/CFS cases and 91 frequency-matched healthy controls. Subjects in the ME/CFS group had significantly decreased levels of plasmalogens and phospholipid ethers (p < 0.001), phosphatidylcholines (p < 0.001) and sphingomyelins (p < 0.001), and elevated levels of dicarboxylic acids (p = 0.013). Using machine learning algorithms, we were able to differentiate ME/CFS or subgroups of ME/CFS from controls with area under the receiver operating characteristic curve (AUC) values up to 0.873. Our findings provide the first metabolomic evidence of peroxisomal dysfunction, and are consistent with dysregulation of lipid remodeling and the tricarboxylic acid cycle. These findings, if validated in other cohorts, could provide new insights into the pathogenesis of ME/CFS and highlight the potential use of the plasma metabolome as a source of biomarkers for the disease. 相似文献
223.
Analysis of users’ check-ins in location-based social networks (LBSNs, also called GeoSocial Networks), such as Foursquare and Yelp, is essential to understand users’ mobility patterns and behaviors. However, most empirical results of users’ mobility patterns reported in the current literature are based on users’ sampled and nonconsecutive public check-ins. Additionally, such analyses take no account of the noise or false information in the dataset, such as dishonest check-ins created by users. These empirical results may be biased and hence may bring side effects to LBSN services, such as friend and venue recommendations. Foursquare, one of the most popular LBSNs, provides a feature called a user’s score. A user’s score is an aggregate measure computed by the system based on more accurate and complete check-ins of the user. It reflects a snapshot of the user’s temporal and spatial patterns from his/her check-ins. For example, a high user score indicates that the user checked in at many venues regularly or s/he visited a number of new venues. In this paper, we show how a user’s score can be used as an alternative way to investigate the user’s mobility patterns. We first characterize a set of properties from the time series of a user’s consecutive weekly scores. Based on these properties, we identify different types of users by clustering users’ common check-in patterns using non-negative matrix factorization (NMF). We then analyze the correlations between the social features of user clusters and users’ check-in patterns. We present several interesting findings. For example, users with high scores (more mobile) tend to have more friends (more social). Our empirical results demonstrate how to uncover interesting spatio-temporal patterns by utilizing the aggregate measures released by a LBSN service. 相似文献
224.
Himanshu M. Joshi 《International Communications in Heat and Mass Transfer》1987,14(6):657-664
The gevernine equation for fully developed laminar natural convection in a vertical annulus have been analytically solved for the isothermal wall boundary conditions. The resulting flow rates and Nusselt numbers are a function of a annulus gap and a non-dimensional temperature ration. These results are compared to those obtained from a finite-difference solution of the developing flow. It is concluded that fullt developed conditions may be assumed for Grashof numbers smaller than 10. 相似文献
225.
SC Langley GW Rickett A Hunt FJ Kelly AD Postle DA York 《Canadian Metallurgical Quarterly》1993,45(3):543-551
The biochemical maturation of the lung in late gestation and in the young animal is regulated by glucocorticoids. The present study was aimed at dissociating the different glucocorticoid receptor sites involved in these regulatory functions. The obese Zucker rat was selected as a model for this study as it exhibits hypersensitivity to glucocorticoid hormone action by virtue of its elevated receptor numbers and activity. Two synthetic steroid analogues were administered to obese animals; RU28362, a specific type II receptor agonist, and the type II antagonist RU486. RU28362 promoted a strong catabolic effect, which was associated with reduced food intake and the abolition of growth in the rats. The agonist, RU28362, attenuated developmental increases in antioxidant enzyme activities, and altered the growth of the tissue. At the age studied, development of the lung phosphatidylcholine (PC) system was almost complete, but RU28362 increased disaturated PC 16:0/16:0 concentrations by almost 2-fold, and altered the molecular composition of total pulmonary PC. RU486 attenuated the growth of the rats and reduced their food intake. Treatment with the type II antagonist attenuated lung growth and increased the activities of pulmonary copper zinc (Cu/Zn) and manganese (Mn) superoxide dismutases. RU486 had no effect on lung PC concentrations and molecular composition. The data suggest a role for type I glucocorticoid receptors in the regulation of the antioxidant enzyme system in the lung, as type II antagonism will channel endogenous glucocorticoid binding to the type I site. Type II receptor binding would appear to play a role in regulating the lung PC content. 相似文献
226.
Three representatives of a novel class of amide (isopeptide) glycoconjugates have been synthesised: N alpha-D-galacturonoyl-L-lysine and N epsilon-D-galacturonoyl-L-lysine and N epsilon-D-polygalacturonoyl-L-lysine. Galacturonoyl-lysine amide bonds were labile in 2 M trifluoroacetic acid at 120 degrees and in alkali, but relatively stable in cold acid. The amide bonds were resistant to digestion by Driselase, Pronase and trypsin. The polysaccharide backbone of N epsilon-D-polygalacturonoyl-L-lysine was hydrolysed by Driselase to yield two major ninhydrin-positive compounds which were shown by 1H and 13C NMR spectroscopy to be tri- and tetra-alpha-(1-->4)-D-galacturonoyl-L-lysines. To investigate the possible natural occurrence of N-galacturonoyl isopeptide bonds, we fed cell-suspension cultures of spinach and tomato with D-[6-14C]glucuronic acid, which radio-labels pectic polysaccharides. The radioactive cell walls were digested with, sequentially, Driselase, mild acid, and proteinases. On electrophoresis at pH 2.0, several of the radioactive digestion-products were cathodic. Some of the cathodic products yielded [14C]galacturonic acid upon complete acid hydrolysis. The existence of these products is compatible with the presence of novel N-galacturonoyl isopeptide bonds, which could serve as cross-links in plant cell walls. 相似文献
227.
Regenerative axon growth in peripheral neurons is accompanied by increased expression of the growth-associated protein GAP-43. We examined the increase of GAP-43 immunoreactivity in DRG neurons following lesions at different distances along the sciatic nerve, using immunocytochemistry. To control for the variable involvement of DRG axons following injury at different sites, injured neurons were identified by retrograde labeling with Fluoro-Gold. GAP-43 labeling was similar for proximal, distal, and far-distal injuries when only injured neurons are considered. Our results stand in contrast to studies which show that GAP-43 upregulation in neurons of the central nervous system occurs only when lesions are made close to the cell body. This suggests that the mechanisms which control GAP-43 expression following injury differ between central and peripheral neurons. 相似文献
228.
Stearoyl-CoA desaturase activity in microsomes from lactating rat mammary gland is very low (0.05–0.15 nmol/min/mg of protein)
regardless of lactating time. In such microsomes, reductase activities and content of cytochrome b5 are several-fold lower than in normal rat liver microsomes. Preincubation of the mammary microsomes with purified terminal
desaturase gives a 55-fold stimulation of stearoyl-CoA desaturase activity, whereas preincubation with cytochrome b5 has no effect. However, preincubation of mammary microsomes with both cytochrome b5 and terminal desaturase results in a 200-fold stimulation of overall desaturation. These observations suggest that negligible
stearoyl-CoA desaturase activity in lactating rat mammary microsomes is due to a low cytochrome b5 content and the absence of terminal enzyme. The hepatic stearoyl-CoA desaturase activity increases 9-fold during lactation.
There is little or no change in the NADH-cytochrome c reductase activity or in the concentration of cytochrome b5 during this period, but the activity of the terminal desaturase increases with the increase of overall desaturation. These
results suggest that liver is one of the more important sources of oleic acid for milk triglycerides. 相似文献
229.
SC Shim DH Yoo JK Lee HK Koh SR Lee SH Oh SY Kim 《Canadian Metallurgical Quarterly》1998,25(12):2464-2468
Ankylosing spondylitis (AS) results in disease-specific inflammation at the site of ligamentous insertion into the bone. Atlantoaxial joint subluxation and vertical subluxation of the axis may occur as a consequence of instability resulting from the inflammatory process. Spontaneous anterior atlantoaxial subluxation is a well recognized complication in about 2% of patients with AS, and presents with or without signs of spinal cord compression. Vertical subluxation may follow anterior or posterior subluxation. It was noted in 3-8% of patients with rheumatoid arthritis, but is an exceedingly rare complication of AS. Moreover, it has never been reported that multiple cerebellar infarction and bulbar symptoms developed spontaneously due to atlanto-occipital subluxation and vertical subluxation in a patient with a long [corrected] history of AS. We describe a man with AS who developed multiple cerebellar infarction due to vertebral artery obstruction and bulbar symptoms associated with atlanto-occipital subluxation and vertical subluxation. 相似文献
230.
We present a linear system for modelling 3D surfaces from curves. Our system offers better performance, stability and precision in control than previous non‐linear systems. By exploring the direct relationship between a standard higher‐order Laplacian editing framework and Hermite spline curves, we introduce a new form of Cauchy constraint that makes our system easy to both implement and control. We introduce novel workflows that simplify the construction of 3D models from sketches. We show how to convert existing 3D meshes into our curve‐based representation for subsequent editing and modelling, allowing our technique to be applied to a wide range of existing 3D content. 相似文献