Prednisolone therapy of idiopathic feline lower urinary tract disease: a double-blind clinical study

A double-blind clinical study was performed to evaluate prednisolone as treatment for idiopathic feline lower urinary tract disease. No differences in response were observed in prednisolone- and placebo-treated cats.     

Kinetics of sol-to-gel transition for poloxamer polyols

Kinetics of gelation for aqueous solutions of poloxamers 407 and 288 were determined using pulse shearometry. The principle of this method for determining the shear modulus of a semisolid was based on generation of a torsional force that is transmitted through the poloxamer sample at discrete time intervals. Three distinct linear phases were observed for the log dynamic shear modulus (G′) vs. time profiles as poloxamer 407 and 288 solutions of varying concentrations were allowed to passively warm at room temperature to a temperature exceeding the sol-to-gel transition temperature, T_m. The beginning of the second exponential phase coincided with the onset of the gelation process as determined by visual observation. Although gelation appeared visually to be complete at the beginning of the third exponential phase of the log G′ vs. time profiles, this last exponential phase may indicate the rate of formation of the polymer network. A comparison of poloxamer 407 [30% (w/w); T_m = 10.9°C] and poloxamer 288 [37% (w/w); T_m = 11.1°C] would suggest that the concentration of poloxamer required to achieve approximately the same gelation temperature for poloxamers having a similar ratio of poly(oxypropylene):poly(oxyethylene) units decreases with increasing molecular weight of the poly(oxypropylene) hydrophobe contained in the copolymer. Results of these preliminary studies suggest that the gelation process was significantly (p < .05) more rapid for poloxamer 407 at a 30% (w/w) concentration compared to a 30% (w/w) solution of poloxamer 288 when the poloxamer solutions were allowed to passively warm at room temperature. In addition, it appears that the rate of gelation for the poloxamer solutions studied was dependent on the rate of heat transfer through the polymer solution.     

Cultured astrocytes express proteins involved in vesicular glutamate release

The objective of this study is to analyze volatile organic compound (VOC) concentrations in Taiwan's drinking water supply. Focusing on Taiwan's three major metropolitan areas--Taipei, Taichung and Kaohsiung (in the north, middle and south, respectively)--171 samples were taken from tap water and 68 from boiled water. Tests showed VOC concentrations were highest in Kaohsiung. This is due to different water sources and methods of treatment. Except for bromoform, trihalomethane (THM) concentrations were highest. Detection rates of toluene and 1,2-dichloroethane were slightly higher than other VOC compounds. VOC concentrations decreased significantly after water was boiled. THMs had a removal rate from 61% to 82%. The authors conclude that the three metropolitan areas contain significantly different levels of VOCs and that boiling can significantly reduce the presence of VOCs. Other sources of pollution that contaminate drinking water such as industrial plants and gas stations must be further investigated.     

Hyperdynamic circulation of cirrhotic rats: role of substance P and its relationship to nitric oxide

BACKGROUND: It has been suggested that excessive formation of nitric oxide (NO) is responsible for the hyperdynamic circulation observed in portal hypertension. Substance P is a neuropeptide partly cleared by the liver and causes vasodilatation through the activation of the endothelial NO pathway. However, there are no previously published data concerning the plasma level of substance P in cirrhotic rats and its relationship to NO. METHODS: Plasma concentrations of substance P and nitrate/nitrite (an index of NO production) were determined in control rats and cirrhotic rats with or without ascites using an enzyme-linked immununosorbent assay and a colorimetric assay, respectively. In addition, systemic and portal hemodynamics were evaluated by a thermodilution technique and catheterization. RESULTS: Cirrhotic rats with and without ascites had a lower systemic vascular resistance (2.6 +/- 0.2 and 3.9 +/- 0.4 mmHg ml(-1) x min x 100 g body weight, respectively) and higher portal pressure (14.6 +/- 0.6 and 11.3 +/- 1.8 mmHg) than control rats (6.5 +/- 0.3 mmHg x ml(-1) x min x 100 g BW and 6.8 +/- 0.2 mmHg, respectively, P < 0.05), and cirrhotic rats with ascites had the lowest systemic vascular resistance. Plasma levels of nitrate/nitrite progressively increased in relation to the severity of liver dysfunction (control rats, 2.7 +/- 0.5 nmol/ml; cirrhotic rats without ascites, 5.6 +/- 1.3 nmol/ml; cirrhotic rats with ascites, 8.3 +/- 2.2 nmol/ml; P < 0.05). Cirrhotic rats with ascites displayed higher plasma values of substance P (57.7 +/- 5.9 pg/ml) than cirrhotic rats without ascites (37.9 +/- 3.1 pg/ml, P < 0.05) and control rats (30.1 +/- 1.0 pg/ml, P < 0.05). There was no significant difference in plasma substance P values between control rats and cirrhotic rats without ascites (P > 0.05). No correlation was found between plasma levels of substance P and nitrate/nitrite (r = 0.318, P > 0.05). CONCLUSIONS: Excessive formation of NO may be responsible, at least partly, for the hemodynamic derangements in cirrhosis. Although substance P may not participate in the initiation of a hyperdynamic circulation in cirrhosis, it may contribute to the maintenance of the hyperdynamic circulation observed in cirrhotic rats with ascites.     

THE DEPENDENCE ON CHEMICAL COMPOSITION OF THE CETANE QUALITY OF HYDROTREATED LIGHT CYCLE OIL

The dependence of the cetane number of hydrotreated light cycle oil on chemical composition has been investigated. Cetane number was related to hydrogen content and aromaticity. The latter was determined by high performance liquid chromatography and also by carbon-13 n.m.r. spectroscopy. Specific correlations were developed in each case and a regression coefficient of 0.99 and a standard error of 1.25 were obtained for the best case. The usefulness of predicting cetane number from fuel composition is discussed.     

Spatial attention to arrays of multidimensional objects.

Encoding briefly displayed arrays of multidimensional objects appears to require selective attention, but this hypothesis is challenged by M. J. Nissen's (1985) finding that properties of an object are reported independently. Selective attention to some objects but not others should produce positive dependence. Theoretical analysis shows that deviations from independence would have been difficult to observe in Nissen's data because of high guessing rates and small sample sizes. Four new experiments showing strong positive dependence in property reports are described. Deviations from independence were highly significant for most Ss. Quantitative modeling shows that selective attention to subsets of objects would produce about the amount of dependence obtained. Rather than challenging attention theories, the amount of dependence in encoding multidimensional objects is consistent with selective attention to either objects or locations. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The geographic variation of cancer incidence in Ontario

OBJECTIVES: Our objectives were (1) to describe an analysis of the spatial pattern of cancer incidence in Ontario and (2) to discuss the quality of data in the Ontario Cancer Registry with respect to the accuracy of local cancer rates. METHODS: Cancer incidence rates were calculated for 22 cancer sites in 49 counties of Ontario during 1976 to 1986. Capture-recapture methods were used to estimate completeness of case registration, and completeness of residence information was also assessed. Spatial autocorrelation was used in measuring the geographic pattern of incidence rates. Comparisons were also made between sexes and with earlier data from 1966 to 1975. RESULTS: The quality of the geographic data in the registry appeared good, and corrections for incomplete or inaccurate registration had little impact. About one third of the sex-site combinations showed some evidence of spatial patterning in the cancer rate. Particularly strong regional variation was noted for cancers of the stomach, lung, uterus, and prostate. CONCLUSIONS: The analysis revealed a number of cancers with significant spatial patterning of risk. Further work is needed to relate the cancer data to other information on potential life-style and environmental factors.