The Limitations of Public Housing: Relocation Choices in a Working-Class Community

Public housing is regarded as a map resource for rehousing families displaced by the urban renewal and highway programs. Yet a study of some 500 families relocated from Boston's West End reveals that the overwhelming majority refused to consider the possibility of living in a housing project, for reasons consistent with their preference for the residential patterns and life-styles prevalent in their former neighborhood. Those who do relocate in projects are not typical of the stable working class, and most frequently are characterized by some personal situation that limits their rehousing choice. Planners are confronted with the alternative of allowing public housing to become a care-taking institution for the disabled elements of the society, or of creating new forms for the public housing subsidy to encourage mobility, to provide satisfactory living environments consistent with the values of the inhabitants, and to permit the kinds of heterogeneity which prevail in existing neighborhoods.     

Comment on “Neighborhood Revitalization and Displacement: A Review of the Evidence”

The issue of neighborhood revitalization and displacement certainly does have a déjà vu quality to it. While government officials, academic housing analysts, and even neighborhood groups seem to approach the problem as if it were a brand new phenomenon, in reality the recent history of displacement under urban renewal, the interstate highway system, and other government programs is very relevant. What is remarkable in the spate of literature that recently has emerged on the issue—of which Sumka's article is quite representative—is the failure to acknowledge that history and the lessons it might offer.     

Driving on Mars with RSVP

The rover sequencing and visualization program (RSVP) suite of tools has been a critical factor in the success of the Mars exploration rover (MER) missions. It would be impossible to prepare the large command loads each sol without the capabilities that it possesses. It has proven to be robust and easy to use and capable of answering key questions about sequence validity and constraints. Certainly, training is required to use RSVP, but this is primarily in the general area of command sequencing and rover operations. Once these concepts are understood, RSVP feels natural for building sequences. RSVP has met its prime requirements of supporting rapid assimilation and understanding of the terrain and operational constraints, rapid sequence generation and validation, and production of documentation and archival products. This can be seen in the very limited number of sols lost due to errors in the command sequences. The success of the MER mission and the tremendous amount of science data collected attest to the capability of RSVP.     

Training feed-forward neural networks with gain constraints

Inaccurate input-output gains (partial derivatives of outputs with respect to inputs) are common in neural network models when input variables are correlated or when data are incomplete or inaccurate. Accurate gains are essential for optimization, control, and other purposes. We develop and explore a method for training feedforward neural networks subject to inequality or equality-bound constraints on the gains of the learned mapping. Gain constraints are implemented as penalty terms added to the objective function, and training is done using gradient descent. Adaptive and robust procedures are devised for balancing the relative strengths of the various terms in the objective function, which is essential when the constraints are inconsistent with the data. The approach has the virtue that the model domain of validity can be extended via extrapolation training, which can dramatically improve generalization. The algorithm is demonstrated here on artificial and real-world problems with very good results and has been advantageously applied to dozens of models currently in commercial use.     

The advanced set-up and control system for Dofasco's tandem coldmill

The new coupled pickle line and cold mill (CPCM) has been processing steel since December 1991 at Dofasco Inc. in Hamilton, Ontario, Canada. This mill rolls both sheet and tin plate. The work rolls for the last stand are often textured by grit blasting to roll “matte” finished strip. A new computer-targeted control system was developed for the roll speeds and gaps, specifically for matte rolling. The new set-up system uses Stone's model, which is more appropriate for the limited reductions evident with the rougher rolls. Conventional automatic gauge control (AGC) systems using thickness measurements after the last stand are limited in performance by the effect of long transport delays. These limitations are particularly critical during mill acceleration and deceleration. The use of a thickness gauge before the stand with matte rolls allows the development of AGC systems using shorter control loops for final gauge control. The AGC system uses a Smith predictor for transport lag, (phase shift), and compensation. The combination of the shorter AGC loop and the Smith predictor allows higher gains to be used in the control system. This set-up and control system has contributed to Dofasco's position as a market leader in thickness performance     

Biochemical basis for a cholesterol-lowering activity of 2-[2"-(1",3"-dioxolane)]-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6- nitro-2H-1-benzopyran (SKP-450), a novel antihypertensive agent

Administration (p.o.) of SKP-450, 2-[2"-(1",3"-dioxolane)]-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6-nitro-2H- 1-benzopyran, a novel antihypertensive agent, to hypercholesterolemic Syrian hamsters led to a significant reduction in plasma lipids in a dose-dependent manner, i.e., a 10.8% to 29% reduction in low-density lipoprotein cholesterol at doses of 0.3 to 10 mg/kg of SKP-450. SKP-450 was found to specifically inhibit the hepatic microsomal lanosterol 14alpha-methyl demethylase (14alpha-DM) in a competitive manner (Ki:2.65 microM). Furthermore, a dose-dependent decrease in the 14alpha-DM activity by SKP-450 parallelled the cholesterol synthetic rate in vitro in both the rat hepatic S10 fractions (supernatants at 10,000 g; IC50:20 microM) and Chinese hamster ovary cells (IC50:23 microM). However, this phenomenon was not seen in AR45 cells, which are deficient in 14alpha-DM, suggesting that 14alpha-DM is the major target for the inhibitory action of SKP-450 in regard to cholesterol biosynthesis.     

U73122 and U73343 inhibit receptor-mediated phospholipase D activation downstream of phospholipase C in CHO cells

We investigated the effects of nitric oxide (NO) donors, S-nitroso-N-acetylpenicillamine and sodium nitroprusside on basal and K+-evoked release of [3H]noradrenaline from superfused synaptosomes from the rat cerebral cortex. Both substances produced concentration-dependent increases in the release of the labeled transmitter under basal and depolarized conditions. The effects of the donors on basal release were Ca2+-independent but were not inhibited by the carrier-uptake blocker, desipramine; the effects were abolished by hemoglobin (an NO scavenger). Thirty-five minutes after stimulation with sodium nitroprusside, the synaptosomes were still responsive to KCl stimulation, indicating that the donor's effects were not caused by damage to the synaptosome membrane. The cGMP analogue, 8-bromo-cGMP, had no effect on basal release, and the enhanced release produced by sodium nitroprusside was not inhibited by the specific inhibitor of soluble guanylate cyclase, 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one, indicating that NO's effects on basal release of the neurotransmitter are guanylate cyclase-independent. Both of the NO donors had more marked effects on release of [3H]noradrenaline during K+-stimulated depolarization. The NO-mediated increase in this case was partially antagonized by 10 microM LH-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one, and 8-Br-cGMP was also capable of producing concentration-dependent increases in the K+-stimulated release of the transmitter. These findings indicate that the effects of the NO donors on [3H]noradrenaline release during depolarization are partially mediated by the activation of guanylate cyclase.     

Familial psoriasis and HLA-B: unambiguous support for linkage in 97 published families

The existence of a psoriasis susceptibility locus, PSORS1 (HUGO/GDB-approved symbol), in or near the HLA region of chromosome 6 is strongly supported by a lod score analysis of HLA-B and psoriasis in 97 families from 16 published datasets. Families included in the dataset represent all the psoriasis families with usable HLA data that we could find in the published literature through May 1997. The recombination fraction between PSORS1 and HLA-B is estimated to be at or near 0.00, with a maximum two-point lod score of 23.7, assuming a dominant mode of inheritance with low (20%) penetrance at the PSORS1 locus. Although these families are geographically and ethnically diverse, there is no evidence for linkage heterogeneity at the HLA-linked locus in this analysis. We also conclude that the HLA-B17 allele, which is strongly associated with psoriasis, is unlikely itself to contribute directly to psoriasis susceptibility; rather, the HLA-B locus is probably tightly linked to the PSORS1 locus. Finally, we raise the possibility of a two-locus/heterogeneity model as one way to reconcile several findings in the literature.     

N-methyl-D-aspartic acid stimulation of vasopressin release: role in osmotic regulation and modulation by gonadal steroids

Previous experiments demonstrated that excitatory amino acids participate in the osmotic regulation of vasopressin secretion, but the specific involvement of N-methyl-D-aspartic acid (NMDA) receptors was not evaluated. This was demonstrated in the present studies. NMDA stimulated vasopressin release from perifused explants of the hypothalamo-neurohypophyseal system (HNS), and osmotic stimulation of vasopressin release was inhibited by MK-801 (10 microM) and AP5 (100 microM) NMDA receptor antagonists. The effective concentration of NMDA was dependent upon the Mg2+ concentration of the perifusate with stimulation observed at 1 microM NMDA in Mg2+-replete compared with 5 microM in low-Mg2+ medium. Previous experiments also demonstrated that estradiol and dihydrotestosterone (DHT) inhibited osmotically stimulated vasopressin secretion, and a nongenomic mechanism of action was suggested by the ability of steroids conjugated to bovine serum albumin to replicate the effect. Experiments were performed to explore the potential role of NMDA receptors in this mechanism. Estradiol (50 pg/ml) and DHT (3 ng/ml) inhibited NMDA stimulated vasopressin release in perifused HNS explants. These results suggest a role of NMDA receptors in the mediation of vasopressin secretion in osmotically stimulated release. Furthermore, estradiol and DHT may exert their inhibitory effect on osmotically stimulated vasopressin release via the NMDA receptor.