Multiple cerebellar infarction due to vertebral artery obstruction and bulbar symptoms associated with vertical subluxation and atlanto-occipital subluxation in ankylosing spondylitis

Ankylosing spondylitis (AS) results in disease-specific inflammation at the site of ligamentous insertion into the bone. Atlantoaxial joint subluxation and vertical subluxation of the axis may occur as a consequence of instability resulting from the inflammatory process. Spontaneous anterior atlantoaxial subluxation is a well recognized complication in about 2% of patients with AS, and presents with or without signs of spinal cord compression. Vertical subluxation may follow anterior or posterior subluxation. It was noted in 3-8% of patients with rheumatoid arthritis, but is an exceedingly rare complication of AS. Moreover, it has never been reported that multiple cerebellar infarction and bulbar symptoms developed spontaneously due to atlanto-occipital subluxation and vertical subluxation in a patient with a long [corrected] history of AS. We describe a man with AS who developed multiple cerebellar infarction due to vertebral artery obstruction and bulbar symptoms associated with atlanto-occipital subluxation and vertical subluxation.     

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

Cyclin D1 is part of a cell cycle control node consistently deregulated in most human cancers. However, studies with cyclin D1-null mice indicate that it is dispensable for normal mouse development as well as cell growth in culture. Here, we provide evidence that ras-mediated tumorigenesis depends on signaling pathways that act preferentially through cyclin D1. Cyclin D1 expression and the activity of its associated kinase are up-regulated in keratinocytes in response to oncogenic ras. Furthermore, cyclin D1 deficiency results in up to an 80% decrease in the development of squamous tumors generated through either grafting of retroviral ras-transduced keratinocytes, phorbol ester treatment of ras transgenic mice, or two-stage carcinogenesis.     

The Dübendorf Study: a population-based investigation on normal values of blood pressure self-measurement

In a retrospective study of 50 consecutive children with posterior fossa tumors treated at Texas Children's Hospital, Houston, Tex., in 1989-1992, we evaluated perioperative factors which might influence the development of postoperative cerebrospinal fluid leaks. Factors analyzed included the presence of preoperative hydrocephalus, the institution of cerebrospinal fluid diversion, and the method of dural closure. No statistically significant impact on subsequent cerebrospinal fluid leakage was demonstrated.     

Application of genetic algorithm-based intuitionistic fuzzy weighted c-ordered-means algorithm to cluster analysis

Knowledge and Information Systems - With the advance of information technology, many fields have begun using data clustering to reveal data structures and obtain useful information. Most of the...     

Solving the bi-objective personnel assignment problem using particle swarm optimization

A particle swarm optimization (PSO) algorithm combined with the random-key (RK) encoding scheme (named as PSORK) for solving a bi-objective personnel assignment problem (BOPAP) is presented. The main contribution of this work is to improve the f₁_f₂ heuristic algorithm which was proposed by Huang et al. [3]. The objective of the f₁_f₂ heuristic algorithm is to get a satisfaction level (SL) value which is satisfied to the bi-objective values f₁, and f₂ for the personnel assignment problem. In this paper, PSORK algorithm searches the solution of BOPAP space thoroughly. The experimental results show that the solution quality of BOPAP based on the proposed method is far better than that of the f₁_f₂ heuristic algorithm.     

Thermal and dielectric properties of zirconyl phosphate compact

Experimental results are presented on the measurements of thermal expansion (up to 1500°C), thermal conductivity (up to 1000°C), dielectric constant (up to 450 °C) and tan (up to 800 °C) of zirconyl phosphate compacts obtained by sintering at 1600°C. The thermal expansion coefficient of the samples at the temperature below 1100°C was less than 1.7 × 10^–6°C^–1. The samples showed a definite shrinkage at temperatures of 1110 and 1470°C due to the phase transformations. The expansion at 1500°C was less than that at 1100°C probably because of the phase transformation. The thermal conductivity at room temperature was a very small value (0.0046 to 0.0065 cal s^–1 cm°C^–1 cm^–2). The dielectric constant was close to 9. The value of tan° (–0.0001) measured is one of the lowest values for ceramic materials.     

Pathogenic Hydrogel? A Novel-Entrapment Neuropathy Model Induced by Ultrasound-Guided Perineural Injections

Entrapment neuropathy (EN) is a prevalent and debilitative condition caused by a complex pathogenesis that involves a chronic compression–edema–ischemia cascade and perineural adhesion that results in excessive shear stress during motion. Despite decades of research, an easily accessible and surgery-free animal model mimicking the mixed etiology is currently lacking, thus limiting our understanding of the disease and the development of effective therapies. In this proof-of-concept study, we used ultrasound-guided perineural injection of a methoxy poly(ethylene glycol)-b-Poly(lactide-co-glycoilide) carboxylic acid (mPEG-PLGA-BOX) hydrogel near the rat’s sciatic nerve to induce EN, as confirmed sonographically, electrophysiologically, and histologically. The nerve that was injected with hydrogel appeared unevenly contoured and swollen proximally with slowed nerve conduction velocities across the injected segments, thus showing the compressive features of EN. Histology showed perineural cellular infiltration, deposition of irregular collagen fibers, and a possible early demyelination process, thus indicating the existence of adhesions. The novel method provides a surgery-free and cost-effective way to establish a small-animal model of EN that has mixed compression and adhesion features, thus facilitating the additional elucidation of the pathophysiology of EN and the search for promising treatments.     

Highly Thermal Stable Polyimides Applied in Flexible Resistive Memory

Flexible memory devices are one of the most crucial elements in the wearable electronics. In this work, polyimides (PIs)-based flexible resistive memory devices with an excellent thermal and mechanical durability are demonstrated. Four kinds of functional PIs are derived from the heterocyclic diamines including 2,6-diaminodibenzo-p-dioxin (OODA) and 2,6-diaminothianthrene, and dianhydrides including 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) and 3,3′,4,4′-biphenyltetracarboxylic dianhydride. PI with diamine of OODA and dianhydride of 6FDA (PI(OODA_6FDA)) possesses outstanding thermal and mechanical properties with a high glass transition temperature of 352 °C, a low coefficient of thermal expansion of 28.1 ppm K⁻¹, and a high elongation at break of 10%. In addition, PI(OODA_6FDA)-based memory shows write-once-read-many behavior with a high on/off current ratio of 10⁶ and a stable data retention, attributed to the donor–acceptor charge transfer between the polymer chains. The retained current levels at a low resistive state can be observed even with thermal treatment at 200 °C for 24 h or 1000 times cyclic bending at a bending radius of 5 mm. These results demonstrate the potential of heterocyclic PIs for flexible resistive memory.     

PHASES IN HIGH ALLOY STEELS AND SUPERALLOYS

<正> 高温合金一般是指以铁、镍或钴形成的面心立方基体(γ)为基的在较高温度下使用的合金,有些合金靠碳化物强化,有些合金靠铝、钛、铌等与镍生成的中间相(γ′或γ″)强化。此外,还要加入一定数量的钼或钨强化固溶体γ,加入微量的硼或锆强化晶界,加入较多的铬以增强合金的抗氧化能力。由此可见,高温合金中的合金元素,无论从种类或数量上来看,都要比合金钢中复杂得多。但是,在奥氏体不锈耐热钢与铁基高温合金之间并无明显的界限,实际上铁基高温合金就是在镍铬不锈耐热钢中不断提高镍的含量和增添新的合金元素而发展出来的。因此,在讨论高温合金中的相时,我们把铬镍不锈耐热钢也包括在内。     

An investigation of laser-assisted machining of Al2O3 ceramics planing

Laser-assisted machining (LAM), an alternative method of fabricating difficult-to-machine materials, uses primarily laser power to heat the local area (without necessarily evaporating or melting any material) before the material is removed. It not only efficiently reduces the cutting force during the manufacturing process but also improves the machining characteristics and geography with regard to difficult-to-machine materials, especially structural ceramics.This study on the application of laser-assisted machining to Al₂O₃ ceramics examines the measurements of cutting force and workpiece surface temperature as well as surface integrity and tool wear. Specifically, it uses the lattice Boltzmann method (LBM) to calculate the temperature distribution inside the ceramic workpiece during the LAM process and ensure that the laser energy causes no subsurface damage. The experimental results reveal that the LAM process efficiently reduces the cutting force by 22% (feed force) and 20% (thrust force) and produces better workpiece surface quality than conventional planing.