The effect of unilateral destruction of the head of the caudate nucleus with kainic acid on the structure of the wakefulness-sleep cycle and the EEG in rats

The wakefulness-sleep cycle characteristics changes in Wistar line rats after unilateral lesions of the neuronal elements of the caudate nucleus head with kainic acid (at sparing the conducting ways going through this structure) were studied. It was shown that in 4 days after acid injection the share of the active wakefulness and light slow-wave sleep is significantly increased, whereas the percentage of the passive wakefulness, deep slow-wave stage, and paradoxal sleep (up to 80%) is reduced. The wakefulness-sleep cycle in rats is completely normalized on the 7th day after injection. The obtained data allow to consider the caudate nucleus as a modulator for wakefulness-sleep cycle, that is the structure involved in the motive activity regulation.     

铸轧5052合金冷隔缺陷产生的机理研究

阐述了5052合金铸轧坯料生产时冷隔缺陷产生的机理,结合超型FATA—HUNTERΦ1003×1850mm机多年的生产实践经验,提出了消除铸轧冷隔缺陷的措施。     

人字闸门底枢结构改进及材料选用

阐述了人字闸门底枢结构组成，分析并总结了现有蘑菇头与铜衬套的优缺点，在此基础上提出了一种全新结构的底枢，其特点是在蘑菇头骨架上镶嵌一层可拆卸的高分子工程合金材料——MGB，铜衬套将改用坚固耐用、耐腐蚀的不锈钢材料，两者的结合，将为人字门船闸底枢的设计提供长寿命、免维护的选择方案，有利于延长船闸的使用、维修周期，便于维修更换，具有一定的市场潜力和较大的社会价值，值得船闸工程开发设计、工程建设以及制造安装等单位推广和应用。     

Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1

Ubiquitin-mediated proteolysis controls the abundance of many cell cycle regulatory proteins. Recent work in Saccharomyces cerevisiae suggests that a complex consisting of Cdc53, Skp1, and a third component known as an F-box protein (termed SCF) in combination with Cdc34 specifically targets regulatory proteins for degradation, and that substrate specificity is likely to be mediated by the F-box subunit. A screen for genetic interactions with a cdc34 mutation yielded MET30, which encodes an F-box protein. MET30 is an essential gene required for cell cycle progression and met30 mutations interact genetically with mutations in SCF components. Furthermore, physical interactions between Met30, Cdc53, Cdc34, and Skp1 in vivo provide evidence for an SCFMet30 complex. We demonstrate the involvement of Met30 in the degradation of the Cdk-inhibitory kinase Swe1. Swe1 is stabilized in met30 mutants and GST-Met30 pull-down experiments reveal that Met30 specifically binds Swe1 in vivo. Furthermore, extracts prepared from cdc34 or met30 mutants are defective in polyubiquitination of Swe1. Taken together, these data suggest that SCF-mediated proteolysis may contribute to the regulation of entry into mitosis. Our data, in combination with previously published results, also provide evidence for distinct SCF complexes in vivo and support the idea that their F-box subunits mediate SCF substrate specificity.     

基于互联网实现多种信息传输技术

随着信息技术的迅速发展,使用互联网实现楼宇内电话、电视、电脑、安防和环境监控、计量数据等信息的合路传输,是实现智能家居和数字楼宇的一种主要发展趋势。最终目的,实现对物和过程的智能化感知。文章首先介绍信息合路编码、中央控管电路,然后介绍网络接口电路原理和系统体系构架。重点介绍多种多样的信息传输技术。它对现代楼宇信息化、智能化建设有很好的参考作用。     

基于泊肃叶方程改进的驱替面积确定方法

为解决B-L水驱前缘理论中前缘推进位置的准确度有限问题,基于泊肃叶方程,通过联立油藏物质平衡方程,转化为地层压力与流管数的最小化问题,运用遗传算法寻优最小目标值,获取各注采方向的流管数,从而确定注采井间驱替面积.该模型量化了B-L方程中驱替面积参数取值,利用改进后的井间驱替面积计算公式,提高了连通的注采井之间水驱前缘推进位置的计算精度.计算结果更加符合油田实际生产,对类似油田的水驱开发效果评价,具有一定的借鉴和指导意义.     

基于新工科背景"数字测图原理与方法"课程教学改革

新工科建设是基于国家战略发展新需求而提出的我国高等工程教育改革的新方向.基于新工科建设背景,文章以"数字测图原理与方法"为研究对象,立足工程教育认证理念,分析测绘工程专业课程体系面临的问题,对课程建设、教学改革进行研究探索.采取"线上线下混合教学、项目案例教学、综合考核"教学模式,课程思政引导、学科竞赛引领的自主学习模式,为测绘工程专业人才培养体系的持续改进优化提供有效支撑.