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排序方式: 共有3285条查询结果,搜索用时 171 毫秒
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Soumya Ghosh Chowdhury Jagannath Chanda Sreedip Ghosh Koushik Banerjee Shib Shankar Banerjee Amit Das Prasenjit Ghosh Sanjay Kr. Bhattacharyya Rabindra Mukhopadhyay 《Polymer Engineering and Science》2020,60(8):1973-1983
Proficiency on underlying mechanism of rubber-metal adhesion has been increased significantly in the last few decades. Researchers have investigated the effect of various ingredients, such as hexamethoxymethyl melamine, resorcinol, cobalt stearate, and silica, on rubber-metal interface. The role of each ingredient on rubber-metal interfacial adhesion is still a subject of scrutiny. In this article, a typical belt skim compound of truck radial tire is selected and the effect of each adhesive ingredient on adhesion strength is explored. Out of these ingredients, the effect of cobalt stearate is found noteworthy. It has improved adhesion strength by 12% (without aging) and by 11% (humid-aged), respectively, over control compound. For detailed understanding of the effect of cobalt stearate on adhesion, scanning electron microscopy and energy dispersive spectroscopy are utilized to ascertain the rubber coverage and distribution of elements. X-ray photoelectron spectroscopy results helped us to understand the impact of CuXS layer depth on rubber-metal adhesion. The depth profile of the CuXS layer was found to be one of the dominant factors of rubber-metal adhesion retention. Thus, this study has made an attempt to find the impact of different adhesive ingredients on the formation of CuXS layer depth at rubber-metal interface and establish a correlation with adhesion strength simultaneously. 相似文献
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PE Sipila VJ Wiebe GB Hubbard SK Koester VD Emshoff JU Maenpaa GT Wurz RC Seymour MW DeGregorio 《Canadian Metallurgical Quarterly》1993,(15):2138-2144
The effects of long-term tamoxifen exposure on cell growth and cell cycle kinetics were compared between oestrogen receptor (ER)-positive (MCF-7) and ER-negative (MDA-MB-231) cell lines. In the MCF-7 cell line, prolonged tamoxifen exposure (0.5 mumol/l for > 100 days) blocked cells in G0-G1 of the cell cycle, and slowed the doubling time of cells from 30 to 59 h. These effects corresponded to an increase in the cellular accumulation of tamoxifen over time [mean area under concentration curve (AUC) = 77.92 mumoles/10(6)/cells/day]. In contrast, in the MDA-MB-231 cell line, long-term tamoxifen exposure had no obvious effect on the doubling time, and reduced cellular tamoxifen accumulation (mean AUC = 50.50 mumoles/10(6)/cells/day) compared to the MCF-7 cells. Flow cytometric analysis of MDA-MB-231 cells demonstrated that a new tetraploid clone emerged following 56 days of tamoxifen exposure. Inoculation of the MDA-MB-231 tetraploid clone and MDA-MB-231 wildtype cells into the opposite flanks of athymic nude mice resulted in the rapid growth of tetraploid tumours. The tetraploid tumours maintained their ploidy following tamoxifen treatment for nine consecutive serial transplantations. Histological examination of the fifth transplant generation xenografts revealed that the tetraploid tumour had a 25-30 times greater mass, area of haemorrhage and necrosis, a slightly higher mitotic index and was more anaplastic than the control neoplasm. The control wildtype MDA-MB-231 tumours maintained a stable ploidy following tamoxifen treatment until the eighth and ninth transplantation, when a tetraploid population appeared, suggesting that tamoxifen treatment may select for this clone in vivo. These studies suggest that prolonged tamoxifen exposure may select for new, stable, fast growing cell clones in vitro as well as in vivo. 相似文献
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Lean philosophy: implementation in a forging company 总被引:2,自引:2,他引:0
Ajit Kumar Sahoo N. K. Singh Ravi Shankar M. K. Tiwari 《The International Journal of Advanced Manufacturing Technology》2008,36(5-6):451-462
This research addresses the implementation of lean philosophy in a forging company with a focus on radial forging production
flow lines. Here, the prime motive is to evolve and test several strategies to eliminate waste on the shop floor. In this
research, a systematic approach is suggested for the implementation of lean principles. This paper describes an application
of value stream mapping (VSM). Consequently, the present and future states of value stream maps are constructed to improve
the production process by identifying waste and its sources. Furthermore, Taguchi’s method of design of experiments is pursued
here to minimize the forging defects produced due to imperfect operating conditions. A noticeable reduction in set-up time
and work-in-process (WIP) inventory level is substantiated. Finally, we conclude with a discussion of managerial implications
and the future scope of research. 相似文献
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The Design of Discrimination Experiments 总被引:1,自引:0,他引:1
Experimentation plays a fundamental role in scientific discovery. Scientists experiment to gather data, investigate phenomena, measure quantities, and test theories. In this article, we address the problem of designing experiments to discriminate between two completing theories. Given an initial situation for which the two theories make the same prediction, the experiment design problem is to determine how to modify the situation such that the two theories make different predictions for the modified situation. The modified situation is called a discrimination experiment. We present a knowledge-intensive method called DEED for designing discrimination experiments. The method analyzes the differences in the two theories' explanations of the prediction for the initial situation. Based on this analysis, it determines modifications to the initial situation that will result in a discrimination experiment. We illustrate the method with the design of experiments to discriminate between several pairs of qualitative theories in the fluids domain. 相似文献
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