全文获取类型
收费全文 | 4700篇 |
免费 | 160篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 35篇 |
化学工业 | 566篇 |
金属工艺 | 50篇 |
机械仪表 | 58篇 |
建筑科学 | 65篇 |
矿业工程 | 1篇 |
能源动力 | 69篇 |
轻工业 | 378篇 |
水利工程 | 21篇 |
石油天然气 | 18篇 |
无线电 | 138篇 |
一般工业技术 | 410篇 |
冶金工业 | 2823篇 |
原子能技术 | 12篇 |
自动化技术 | 218篇 |
出版年
2024年 | 4篇 |
2023年 | 12篇 |
2022年 | 31篇 |
2021年 | 75篇 |
2020年 | 52篇 |
2019年 | 73篇 |
2018年 | 64篇 |
2017年 | 85篇 |
2016年 | 82篇 |
2015年 | 62篇 |
2014年 | 99篇 |
2013年 | 136篇 |
2012年 | 98篇 |
2011年 | 146篇 |
2010年 | 101篇 |
2009年 | 126篇 |
2008年 | 101篇 |
2007年 | 96篇 |
2006年 | 70篇 |
2005年 | 60篇 |
2004年 | 65篇 |
2003年 | 57篇 |
2002年 | 44篇 |
2001年 | 33篇 |
2000年 | 51篇 |
1999年 | 106篇 |
1998年 | 914篇 |
1997年 | 538篇 |
1996年 | 330篇 |
1995年 | 211篇 |
1994年 | 176篇 |
1993年 | 188篇 |
1992年 | 34篇 |
1991年 | 39篇 |
1990年 | 52篇 |
1989年 | 48篇 |
1988年 | 43篇 |
1987年 | 44篇 |
1986年 | 48篇 |
1985年 | 20篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1982年 | 11篇 |
1981年 | 11篇 |
1980年 | 22篇 |
1979年 | 4篇 |
1978年 | 9篇 |
1977年 | 51篇 |
1976年 | 114篇 |
1975年 | 4篇 |
排序方式: 共有4862条查询结果,搜索用时 15 毫秒
11.
The potential of a gonadotropin-releasing hormone (GnRH) agonist (goserelin acetate), delivered constantly for 28 days via a subcutaneous depot, to induce ovulation in seasonally anestrous mares, was investigated. Two experiments were conducted, in which a range of doses (30 to 240 micrograms/mare/d) was examined. Mares were selected on the basis of lack of substantial follicular development (follicle diameter < 20 mm determined ultrasonically) and low serum concentrations of luteinizing hormone (LH) and progesterone. Constant administration of the GnRH agonist-induced ovulation in anestrous mares, but a dose-response relation was not observed. Furthermore, with identical doses tested in consecutive or alternate years, considerable variation was observed in the ovulatory response. In general, ovulation in all treated mares was accompanied by increased circulating concentrations of LH and a decrease in follicle-stimulating hormone values. Ovulation was preceded by an increase in estradiol and LH concentrations. In mares in which ovulation did not occur, concentration of LH increased during agonist treatment, whereas that of follicle-stimulating hormone either increased or did not change. It was concluded that constant administration of GnRH agonists may induce ovulation in mares during seasonal anestrus; however, percentage of mares ovulating and the lack of reproducibility of effect indicate that this approach is inappropriate for use as a reliable method to manipulate breeding activity in commercial broodmares. 相似文献
12.
13.
PJ Jenkins MA Satta M Simmgen WM Drake C Williamson DG Lowe K Britton SL Chew RV Thakker GM Besser 《Canadian Metallurgical Quarterly》1997,47(6):747-751
We report a patient with a metastatic parathyroid carcinoma and medullary carcinoma of the thyroid. This patient represents a variation of the multiple endocrine neoplasia syndrome (MEN) type 2A. There was no evidence of a phaeochromocytoma. The case illustrates the difficulties that may be encountered in localising the source of PTH secretion; the patient underwent four unsuccessful exploratory operations of the neck and mediastinum before further investigations revealed a single metastatic deposit of parathyroid carcinoma involving the first thoracic vertebra. PCR amplification and sequencing of the RET oncogene from the metastatic parathyroid carcinoma and genomic DNA revealed a heterozygous mutation (Cys634Tyr) in exon 11, as has previously been described to occur in MEN 2A. In addition, loss of tumour heterozygosity was demonstrated at loci from chromosomes 1, 2, 3p, 13q and 16p. This represents the first report of a parathyroid carcinoma in a MEN2A patient, in which the multiple allelic deletions are consistent with the generalised losses observed in aggressive tumours. 相似文献
14.
A central paradigm of immunology is clonal selection: lymphocytes displaying clonally distributed antigen receptors are generated and subsequently selected by antigen for growth or elimination. Here we show that in mice transgenic for anti-H-2Kk,b antibody genes, in which a homogeneous clone of developing B cells can be analyzed for the outcome of autoantigen encounter, surface immunoglobulin M+/idiotype+ immature B cells binding to self-antigens in the bone marrow are induced to alter the specificity of their antigen receptors. Transgenic bone marrow B cells encountering membrane-bound Kb or Kk proteins modify their receptors by expressing the V(D)J recombinase activator genes and assembling endogenously encoded immunoglobulin light chain variable genes. This (auto)antigen-directed change in the specificity of newly generated lymphocytes is termed receptor editing. 相似文献
15.
KW Sax SM Strakowski PE Keck SL McElroy SA West SP Stanton 《Canadian Metallurgical Quarterly》1998,44(8):784-786
BACKGROUND: This study examined patients with a first-episode of affective psychosis during acute and compensated states in order to determine whether changes in attentional functioning over time were accompanied by changes in the severity of psychotic or affective symptoms. METHODS: Attentional performance was measured in patients (n = 27) using the degraded-stimulus continuous Performance Test (CPT) and symptoms were assessed at the time of index hospitalization, and 2 months after discharge. A comparison group of normal volunteers (n = 31) also performed the CPT two months apart. RESULTS: Patients performed significantly worse than controls at the initial testing but not at follow-up. The improvement in attentional performance significantly correlated with decreased severity of manic symptoms. CONCLUSIONS: Results suggest attentional dysfunction is a state-dependent characteristic of mania, and may provide an additional measure of clinical improvement following treatment. 相似文献
16.
J García-Martínez JA Castro M Ramón A Latorre A Moya 《Canadian Metallurgical Quarterly》1998,149(3):1377-1382
The evolution of Drosophila subobscura mitochondrial DNA has been studied in experimental populations, founded with flies from a natural population from Esporles (Majorca, Balearic Islands, Spain). This population, like other European ones, is characterized by the presence of two very common (>96%) mitochondrial haplotypes (called I and II) and rare and endemic haplotypes that appear at very low frequencies. There is no statistical evidence of positive Darwinian selection acting on the mitochondrial DNA variants according to Tajima's neutrality test. Two experimental populations, with one replicate each, were established with flies having a heterogeneous nuclear genetic background, which was representative of the composition of the natural population. Both populations were started with the two most frequent mitochondrial haplotypes, but at different initial frequencies. After 13 to 16 generations, haplotype II reached fixation in three cages and its frequency was 0.89 by generation 25 in the fourth cage. Random drift can be rejected as the force responsible for the observed changes in haplotype frequencies. There is not only statistical evidence of a linear trend favoring a mtDNA (haploid) fitness effect, but also of a significant nonlinear deviation that could be due to a nuclear component. 相似文献
17.
18.
19.
Integrating principles from a variety of theory has led to the development of a conceptual framework for reengineering in a clinical care delivery setting to improve the value of services provided to the customer. A conceptual framework involving the identification of three high level core processes to reengineer can provide clarity and focus for clinicians to begin directing reengineering efforts. Those core processes are: clinical management of the patient's medical needs, patient operational processes to support the clinical processes, and administrative decision-making processes to support the implementation of the clinical and operational processes. Improvement in any one of these areas has the potential to increase value, but the concurrent targeting of these core processes for reengineering has provided a synergy that has accelerated the achievement of the desired outcomes in the area of surgical services. 相似文献
20.
Identification of a gene that causes primary open angle glaucoma 总被引:3,自引:0,他引:3
EM Stone JH Fingert WL Alward TD Nguyen JR Polansky SL Sunden D Nishimura AF Clark A Nystuen BE Nichols DA Mackey R Ritch JW Kalenak ER Craven VC Sheffield 《Canadian Metallurgical Quarterly》1997,275(5300):668-670
Glaucoma is a major cause of blindness and is characterized by progressive degeneration of the optic nerve and is usually associated with elevated intraocular pressure. Analyses of sequence tagged site (STS) content and haplotype sharing between families affected with chromosome 1q-linked open angle glaucoma (GLC1A) were used to prioritize candidate genes for mutation screening. A gene encoding a trabecular meshwork protein (TIGR) mapped to the narrowest disease interval by STS content and radiation hybrid mapping. Thirteen glaucoma patients were found to have one of three mutations in this gene (3.9 percent of the population studied). One of these mutations was also found in a control individual (0.2 percent). Identification of these mutations will aid in early diagnosis, which is essential for optimal application of existing therapies. 相似文献