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91.
Glioblastoma leads to a fatal course within two years in more than two thirds of patients. An essential cornerstone of therapy is chemotherapy with temozolomide (TMZ). The effect of TMZ is counteracted by the cellular repair enzyme O6-methylguanine-DNA methyltransferase (MGMT). The MGMT promoter methylation, the main regulator of MGMT expression, can change from primary tumor to recurrence, and TMZ may play a significant role in this process. To identify the potential mechanisms involved, three primary stem-like cell lines (one astrocytoma with the mutation of the isocitrate dehydrogenase (IDH), CNS WHO grade 4 (HGA)), and two glioblastoma (IDH-wildtype, CNS WHO grade 4) were treated with TMZ. The MGMT promoter methylation, migration, proliferation, and TMZ-response of the tumor cells were examined at different time points. The strong effects of TMZ treatment on the MGMT methylated cells were observed. Furthermore, TMZ led to a loss of the MGMT promoter hypermethylation and induced migratory rather than proliferative behavior. Cells with the unmethylated MGMT promoter showed more aggressive behavior after treatment, while HGA cells reacted heterogenously. Our study provides further evidence to consider the potential adverse effects of TMZ chemotherapy and a rationale for investigating potential relationships between TMZ treatment and change in the MGMT promoter methylation during relapse.  相似文献   
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Measuring the aberrations of optical systems is an essential step in the fabrication of high precision optical components. Such a characterization is usually ba...  相似文献   
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The EU EuroClim project developed a system to monitor and record climate change indicator data based on satellite observations of snow cover, sea ice and glaciers in Northern Europe and the Arctic. It also contained projection data for temperature, rainfall and average wind speed for Europe. These were all stored as data sets in a GIS database for users to download. The process of gathering requirements for a user population including scientists, researchers, policy makers, educationalists and the general public is described. Using an iterative design methodology, a user survey was administered to obtain initial feedback on the system concept followed by panel sessions where users were presented with the system concept and a demonstrator to interact with it. The requirements of both specialist and non-specialist users is summarised together with strategies for the effective communication of geographic climate change information.  相似文献   
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The article describes an analog electronic circuit for driving stick-slip piezoelectric linear actuators. The task for the amplifier is to provide a high-voltage asymmetric sawtooth-like signal and feed it into a capacitive load. Generation of excessive heat must be avoided while maximizing the slew rate. In order to guarantee a steady translation, the hysteretic behaviour of the piezoelectric material must be compensated. Combination of a charge control scheme with switching is proposed as an efficient solution. Laboratory experiments confirm the superiority of this tailored solution over other existing techniques based on versatile linear voltage amplifiers.  相似文献   
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Reconfigurable handling system   总被引:1,自引:0,他引:1  
The demand for more versatile assembly and handling systems to facilitate customized production is gaining in importance, especially with regard to the constantly-increasing cost pressure, to expansion of the range of product versions and the shortening of innovation cycles. As a cost-effective approach for frequently changing assembly tasks, a novel manipulation concept has been developed by combining given robot technologies. This new handling system has a modular and adaptable layout, which consists of several mobile arms to manipulate the object in six-dimensional Cartesian space. After grasping, when the arms are attached to the object, the mechanical architecture is similar to parallel manipulators or cooperating robots. As the mounting and gripping points of the arms can easily be changed, the manipulator can be reconfigured so as to match the user’s preferences and needs. In addition to the kinematic adaption the regarding task, the hardware and new functions can be reconfigured as well. Contact elements, measurement and assembly devices as well as testing modules can easily be in integrated in the concept. A modular automatic control concept combined with a self-optimizing planning tool helps the user to find the optimal configuration and realize it in an economic way.  相似文献   
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Asymptotic analyses of the mechanical fields in front of stationary and propagating cracks are important for several reasons. For example, they facilitate the understanding of the mechanical and physical state in front of crack tips, and they enable prediction of crack growth. Furthermore, efficient modelling of arbitrary crack growth by use of XFEM (extended finite element method) requires accurate knowledge of the asymptotic crack tip fields. The present study focuses on the asymptotic fields in front of a crack that propagates dynamically in rubber. Static analyses of this type of problem have been made in previous studies. In order to be able to compare the present results with these earlier studies, the constitutive model from Knowles and Sternberg (J. Elast. 3:67–107, 1973) was adopted. It is assumed that viscoelastic stresses become negligible compared with the singular elastic stresses close to the crack tip. The present analysis shows that in materials with a significant hardening, the inertia term in the equations of motion becomes negligible in the asymptotic analysis. However, for a neoHookean type of model, inertia comes into play and causes a maximum theoretical crack speed that equals the shear wave speed.  相似文献   
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