Analysis of stiffness loss in cross-ply composite laminates

The behaviour of laminated composite plates beyond first-ply failure has been the subject of much research work. It is well known that generally, the load-bearing capability of laminated composite plates can remain significant despite the presence of some damage in the plies. Traditionally, the ply-discount method has been used among analysts and designers, although the approach is generally regarded as too conservative. It is therefore desirable to develop models for the prediction of the mechanical properties of damaged composite laminates at various applied loads, and to be able to correlate the changes in properties with the amount of damage and cracking within each constituent ply. Generally, if the models are to be useful as predictive tools, they must be capable of not only sufficiently describing the damage state but also the nature of the damage evolution with loading. This ‘evolution law’ is often obtained through fracture analysis, although it should be noted that the diffused nature of cracks and the multiplicity of failure modes in composites in general greatly complicates the analysis. The problem of transverse matrix cracking in cross-ply laminates under uniaxial tension is considerably simpler because it is essentially dominated by mode I fracture. Thus it is necessarily the first step for any model aiming to predict stiffness losses in composite laminates. In this paper, a constitutive model of the damage state for composite laminates, first proposed by Allen et al., is used with a damage evolution criterion based on strain energy to predict the stiffness loss due to matrix cracking in cross-ply laminated composite plates. Although the constitutive model does not require the determination of many constants, the state of damage is described by a vector of internal state variables (ISV), which contains information on the crack geometry and fracture modes. A series of parametric finite element analyses was performed to determine the effects of relative ply thicknesses, crack density and crack opening profile on the vector of ISVs. A computer algorithm was written for the analysis of cross-ply laminates based on the damage evolution criterion proposed in this work. The results of the analysis compare favourably with experimental measurements of progressive stiffness loss in damaged cross-ply graphite-epoxy laminates obtained from other researchers.     

pRJ5: a naturally occurring Staphylococcus aureus plasmid expressing constitutive macrolide-lincosamide-streptogramin B resistance contains a tandem duplication in the leader region of the ermC gene

The 2.55 kb Staphylococcus aureus plasmid, pRJ5, confers constitutive resistance to macrolide-lincosamide-streptogramin B (MLS) antibiotics. pRJ5 is nearly identical to the inducible MLS resistance plasmid pT48, and has homology with the S. aureus plasmids pE194 and pSN2. The HindIII-C and/or Hind-B fragments were required for stable maintenance of the plasmid and probably carry palA. Plasmids pRJ5 and pT48 were shown to belong to the same incompatibility group, Inc12 (L). DNA sequencing showed that pRJ5 contains a 28 bp direct tandem duplication in the leader/attenuator region of ermC. This is likely to change the secondary structure of the methylase mRNA, allowing constitutive expression of ermC. The type of mutation found on plasmid pRJ5 is different from those observed in similar 2.5 kb constitutive MLS-resistance plasmids isolated from other Gram-positive bacteria, including staphylococci.     

Relationships between dental hygienists' career attitudes and their retention of practice. Part II. From the results of the Ohio Dentist and Dental Hygiene Surveys

This article utilizes findings from the Ohio Dental Hygiene Survey and Ohio Dentist Survey to uncover what specific dental hygiene attitudes exist relative to employment and what factors have led to job termination and to re-entry. Ohio dental hygiene employees are most satisfied with patient relationships, co-worker relationships, and flexible working hours. The dental hygienists are least satisfied with fringe benefits, financial growth, and career creativity. Salary, benefits, nor career longevity were significant factors in determining satisfaction. Dental hygienists who were not working when surveyed, said they would consider returning to practice if a better salary were available, if they could find part-time work, if there were a good wage scale with benefits, or if their own financial need changed. Thirty-six percent of the non-practitioners said they would not ever consider returning to practice due to working conditions, establishment of a new career, or inadequate compensation. Dentist employers stated that they were satisfied or very satisfied with their dental hygienists' patient care and contribution to the practice.     

Effects of L-malate, an inhibitor of glutamate decarboxylase, on learning and memory in mice

Oral administration of L-malate 600 mg.kg-1 for 5 days before training can significantly promote memory acquisition, consolidation and retrieval, respectively, on anisodine-, chloramphenicol-, and ethanol-induced memory impairment in mice. Ketamine (8.5 mg.kg-1, i.p.), a selective NMDA receptor antagonist, was found to inhibit the anti-amnesic activity of L-malate. The glutamate (Glu) and GABA content in mice brain was measured by high-performance liquid chromatography with fluorescence detection. The content of GABA was shown to be decreased from 2.3 +/- 0.5 mumol.g-1 to 1.3 +/- 0.5 mumol.g-1 (P < 0.01), so the Glu/GABA ratio was increased significantly. These results suggest that the decrease of cerebral GABA level and the increase of Glu/GABA ratio is favorable to learning and memory.     

Prevalence of pyruvate kinase deficiency among the Chinese: determination by the quantitative assay

The prevalence of pyruvate kinase (PK) deficiency among the Chinese population has not been established. Fung et al. (Arch Dis Child 44:373-376, 1969) and Wu et al. (Am J Hematol 20:139-144, 1985) indicate 3.4% and 2.1% PK deficiency prevalence rates, respectively, the higher figure based on Beutler's screening test [3] without confirmatory testing. Neither figure is consistent with the occurrence of hemolytic anemia from this cause in the experiences of hematologists in Hong Kong. Using the standard quantitative assay, we measured PK activity in blood samples from 1,100 local Chinese people. The assay was automated on a centrifugal analyser, and the results were expressed in IU per gram of hemoglobin (IU/g Hb). Blood samples from 497 healthy male adults were measured, and PK activity was found to have a range of 15.2 +/- 5.2 (mean +/- 2 SD). A total of 100 cord blood samples were also measured, and the reference interval for this subgroup was 17.7 +/- 4.8. Additionally, samples from 503 anaemic patients were measured, and all were found to have values above the lower limit of the reference interval. The prevalence of PK deficiency among the Hong Kong Chinese population determined by this study was < 0.1%.     

Axons modulate the expression of transforming growth factor-betas in Schwann cells

We have investigated the expression of transforming growth factor (TGF)-beta 1,-beta 2, and -beta 3 in developing, degenerating, and regenerating rat peripheral nerve by immunohistochemistry and Northern blot analysis. In normal adult sciatic nerve, TGF-beta 1, -beta 2, and -beta 3 are detected in the cytoplasm of Schwann cells, and the levels of TGF-beta 1 and -beta 3 mRNAs are constant during post-natal development. When sciatic nerves are transected to cause axonal degeneration and prevent axonal regeneration, the level of TGF-beta 1 mRNA in the distal nerve-stump increases markedly and remains elevated, whereas the level of TGF-beta 3 mRNA falls modestly and remains depressed. When sciatic nerves are crushed to cause axonal degeneration and allow axonal regeneration, the level of TGF-beta 1 mRNA initially increases as axons degenerate, and then falls as axons regenerate. TGF-beta 2 mRNA was not detected in developing or lesioned sciatic nerves at any time. Cultured Schwann cells have high levels of TGF-beta 1 mRNA, the amount of which is reduced by forskolin, which mimics the effect of axonal contact. These data demonstrate that Schwann cells express TGF-beta 1, -beta 2, and -beta 3, and that TGF-beta 1 and -beta 3 mRNA predominate over TGF-beta 2 mRNA in peripheral nerve. Axonal contact and forskolin decrease the expression of TGF-beta 1 in Schwann cells.     

The efficacy of osteoquin in treating the postmenopausal and senile forms of osteoporosis

A 1-year administration of osteoquine (7-isopropoxyisoflavon) to 20 patients with postmenopausal and senile systemic osteoporosis has shown a pronounced analgetic effect of this drug, its ability to stop the loss of and in some instances to increase bone mass, to stimulate osteogenesis.     

An investigation of the filtration capacity and the fate of large filtered sterically-stabilized microspheres in rat spleen

The results from a recent study by Bruce and Schurg (1990) indicate that the gluteus medius (Gm) of the horse is a complex muscle subdivided by an internal tendinous sheet into two regions (dorsal and ventral) which may subserve different functions. In the present study, both regions were found to contain a similar proportion of histochemically-determined muscle fibre types. Fibre type composition did not generally vary over the length of the muscle at the same relative depth. In contrast, there was a significant tendency for the percentage of type I fibres to increase gradually in accordance with depth. These histochemical results do not suggest that the two regions of the Gm assume distinct functional roles; they do, however, indicate that at a given relative depth the muscle fibre type distribution is relatively uniform over the length of the muscle. Nevertheless, care should be exercised in sampling and interpreting data obtained from limited biopsy of equine Gm, due to the substantial histochemical variation of fibre type composition as a function of sampling depth.