Therapy for cerebral ischemic injury with erythropoietin-containing nanoparticles

In this study we prepared nanocarrier of erythropoietin (EPO) and the curative effect of the EPO-containing nanoparticles for periventricular leukomalacia (PVL) model was validated. It was demonstrated that EPO-containing nanoparticles can ameliorate drug-induced liquefaction caused by hypoxia. EPO-containing nanomedicine may open new therapeutic strategies in hypoxia cure.     

工作流管理系统设计与实现

近年来,分布式工作流系统已经成为计算机方面的研究热点。工作流管理系统能够在生产设计过程中提高效率、降低成本、提高竞争力。随着网络技术和软件技术的发展,工作流系统已经得到了广泛的应用。通过介绍工作流管理系统的基本概念和结构,提出了一种基于J2EE的工作流管理系统的设计方案,使用shark开源工作流引擎,采用分布式策略将工作流系统功能模块化。通过对总体过程进行描述,各个模块间的相互配合工作,实现了B/S结构的工作流管理系统并应用于飞行器设计系统中。     

Dynamic characteristics and stability criterion of rotary galloping gait with an articulated passive spine joint

Based on the simplified planar quadruped model with a passive spine joint, this paper focuses on studying the effect of the spine joint on the dynamic performance and the stability of the rotary galloping gait. The stable, periodic, and symmetric rotary galloping gait is achieved by the particle swarm optimization method without any parameter symmetry for leg motion and without any limitation for spine motion. By analyzing the symmetric pattern of the rotary galloping gait, the stability criterion is derived: the closer to zero is the pitching angle at peak time of the center of mass, the better is the stability of the galloping gait. Then, we study the effect of rear leg touchdown angle and spine stiffness on the stability. Moreover, the unstable rotary galloping gait can be stabilized by adjusting one or more of the touchdown angle, spine stiffness, and leg stiffness. Furthermore, the effect of the spine stiffness on the key kinematic and kinetic properties is also studied for different initial values and mechanical parameters. The presented stability criterion and the achieved dynamic performance analysis results will be instructive for the design and control of the quadruped robot.     

Biophotonic probes for bio-detection and imaging

The rapid development of biophotonics and biomedical sciences makes a high demand on photonic structures to be interfaced with biological systems that are capab...     

跨尺度混合注意力的遥感图像超分辨率重建

为了解决现有遥感图像超分辨率重建模型对长期特征相似性和多尺度特征相关性关注不足的问题, 提出了一种基于跨尺度混合注意力机制的遥感图像超分辨率重建算法. 首先提出了一个全局层注意力机制(global layer attention, GLA), 利用层注意力机制加权融合不同层级的全局特征, 建模低分辨率与高分辨率图像特征间的长期依赖关系. 同时, 设计了跨尺度局部注意力机制(cross-scale local attention, CSLA), 在多尺度的低分辨率特征图中寻找与高分辨率图像匹配的局部信息补丁, 并融合不同尺度的补丁特征, 以优化模型对图像细节信息的恢复能力. 最后, 提出一种局部信息感知损失函数来指导图像的重建过程, 进一步提高了重建图像的视觉质量和细节保留能力. 在UC-Merced数据集上的实验结果表明, 本文方法在3种放大倍数下的平均PSNR/SSIM优于大多数主流方法, 并在视觉效果方面展现出更高的质量和更好的细节保留能力.     

过程模拟研究进展

随着计算机技术的不断发展, 过程模拟在各行各业中的应用越来越广泛. 过程模拟使用模拟模型来模仿业务流程行为, 它可以用于预测和优化系统的性能, 评估决策的影响并向管理者提供决策依据, 也可以用于减少实验成本和时间. 目前, 如何高效地去构建一个可以信任的仿真模型得到了广泛关注. 本文通过追踪、归纳和分析关于构建业务过程模拟模型方法的相关研究文献, 对基于过程模型、系统动力学和深度学习的3种仿真建模方法的流程、优缺点和研究进展进行了阐述, 并探讨了过程模拟面临的挑战和未来的发展方向, 以期为业务过程模拟未来的研究方向提供参考.     

面向换热设备的行业标准件设计

随着应用领域日益扩大,换热设备明显呈现出多品种、小批量、单件生产的趋势。为了缩短产品的设计和生产工期,增强企业的竞争力,基于Solidworks平台建立换热设备标准件库。这不仅避免了设计人员许多重复性劳动,而且使产品的设计效率和制造质量都得到可靠保证。     

汽车覆盖件修边与翻边工序的快速仿真系统

基于UGNX平台开发了覆盖件修边与翻边工序快速仿真系统(TFA).该系统基于有限元逆算法,根据翻边形状反向快速计算修边线尺寸以及翻边成形中可能出现的起皱和破裂等缺陷.由于修边线展开与翻边分析无缝集成UGNX中,避免了CAD与CAE系统数据转换时模型数据丢失和精度损失,缩短了工艺设计周期,为工艺设计人员提供一种方便的修边和翻边快速仿真工具.以汽车后围修边线展开与翻边成形为例,通过TFA计算结果与实验结果的比较,验证了TFA系统算法的可行性与精确性.     

基于FP-Tree的共享前缀频繁项集挖掘算法

在数据挖掘中发现关联规则是一个基本问题,而发现频繁项集是关联规则挖掘中最基本、最重要的问题。提出了基于FP-Tree的共享前缀频繁项集挖掘算法－FP-SPMA算法。构造FP-Tree来压缩事务数据库,通过共享前缀和前瞻剪枝快速减小候选项集,无需递归构造条件模式树,算法性能有明显的提高。     

Headquarter-centered common sourcing management through order coordination and consolidation

It is common for subsidiaries of a group company to use the same types of components for producing similar products. Different subsidiary companies may well procure such components from the same suppliers. This paper studies two sourcing management models. One is the Subsidiary-Autonomous Sourcing Management (SD-ASM) where subsidiaries manage their inventories and place purchasing orders independent of each other. The other is the Headquarter-centered Common Sourcing Management (HQ-CSM) where purchasing orders of subsidiaries are processed centrally through some kind of headquarter coordination. In the SD-ASM model, each subsidiary places replenishment orders at a time interval corresponding to their economic order quantity (EOQ). In the HQ-CSM model, two purchasing order management policies are examined. One is the Order Coordination policy in which common replenishment epochs or time periods are proposed by the headquarter and the subsidiaries are encouraged to coordinate the timing of their orders based on the common replenishment epochs. The other is the Order Consolidation policy in which the subsidiaries combine the quantity of their orders and the headquarter places a combined order with the supplier. In the Order Coordination policy, classic RAND heuristic is used to find the best common replenishment epoch and the best replenishment timing of each subsidiary. In the Order Consolidation policy, the optimal order quantity of the combined order is obtained from a mathematical model. The combined order is then allocated to the subsidiaries according to a proportional allocation rule. A series of numerical studies is conducted to compare the costs of the SD-ASM and HQ-CSM policies. The results show that HQ-CSM outperforms SD-ASM in terms of cost and robustness against demand uncertainties. This achievement is largely due to the economies of process (synergistic ordering process), the economies of scale (large order quantity with price discount) and risk pooling effect (transshipments). The results also reveal that the Order Consolidation policy with a combined order always performs better than the Order Coordination policy with common replenishment epochs especially in face of high demand uncertainties and high service level in the global market.