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41.
Pacemaker therapy in patients with atrial fibrillation means the best current pacemaker therapy for patients with bradycardias with the aim to avoid the onset of atrial fibrillation and to establish DDD pacing despite of a history of atrial tachyarrhythmias. The newer application of pacing is the suppression of atrial arrhythmias in patients with medical refractory atrial tachyarrhythmias. Patients with slow ventricular rates and permanent atrial fibrillation should receive a VVI-pacemaker, if the bradycardias causes syncope, dizziness or a decrease of their exercise tolerance. In case of chronotropic incompetence the pacemaker should provide rate responsive pacing. Patients with sick sinus syndrome should receive an atrial (AAI) or dual-chamber (DDD) pacemaker, because patients with these in contrast to VVI-pacemakers develop less often atrial fibrillation and subsequent complications such as atrial thromboembolism. A dual-chamber or VDD-pacemaker--the latter connected to a VDD-single-lead--is indicated in patients with advanced AV-block. Atrial fibrillation occurs in 3 to 6% of the patients with no history of arrythmia and is, if pacemakers have no automatic mode switch, an often reason to program the devices to the VVI-pacing mode. Nowadays, most DDD(R)-pacemakers provide an automatic mode switch: During an atrial tachycardia the pacemaker switches to a VVI/VVIR mode and restores the initial DDD(R)-pacing mode with termination of the arrhythmia. In respect to the newer applications, one approach to prevent atrial tachyarrhythmias is permanent atrial pacing. As lower pacing rates of 80 to 90 ppm are usually needed and many patients hardly tolerate these pacing rates, new algorithms are under clinical investigation. Another approach is the simultaneous depolarization of the right and left atrium. Biatrial pacing is performed with one lead in the high right atrium and another lead in the coronary sinus. Another solution is bifocal atrial pacing with leads placed in the high right atrium and in the coronary sinus ostium. One effect of the new pacing techniques is to shorten interatrial conduction times. Therefore, biatrial pacing has become a therapy to prevent atrial arrhythmias deriving from delayed interatrial conduction times. As atrial reentry circuits seem to be important in atrial fibrillation, multisite atrial pacing is also performed in patients with medical refractory paroxysmal atrial fibrillation. Preliminary results suggest a more effective prevention of atrial fibrillation; nevertheless, these techniques should be still restricted to patients enrolled in clinical studies.  相似文献   
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The analytical review covers the key factors that influence permeability of a coalbed under mining-induced alteration of stress state. The authors put forward an analytical relation between coal permeability, stresses and adsorbed gas to define parameters of gas leakage zone parameters and laws of mass transfer. The analytically derived relation is compared with the known model of coal structure and with the experimental results. The proposed model of coalbed permeability allows mechanism of leakage and localization of seepage zones in coal provided that the model parameters are properly selected or found experimentally.  相似文献   
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Acid-base properties of active sites of supported palladium catalysts and individual substrates are studied with the use of potentiometry and pK spectroscopy. The nature and composition of the substrate, as well as the method of production of the supported catalyst, are shown to affect the character of hydrogen adsorption. Spectra of certain supported catalysts are considered.  相似文献   
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This paper examines the physicochemical properties and microstructure of brushite calcium phosphate cements possessing strength acceptable for application in surgery (15–20 MPa) and ensuring an optimal acidity (pH 6.5–7.5) of solutions in contact with them. Holding in a physiological saline produces significant changes in the microstructure of the cement relative to that before immersion in the solution: it causes a transformation of the most soluble components into platelike hydroxyapatite crystals.  相似文献   
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The dynamic rearrangement of the structure of vortex domain walls (DWs) in films with uniaxial in-plane anisotropy has been examined based on two-dimensional micromagnetic model simulation. The optimum computational region has been chosen; grids with up to 270 × 75 cells 3 nm in size have been used. The scenarios of dynamic rearrangement of the DW structure in strong fields (up to 450 Oe) and in films with thicknesses exceeding 100 nm have been revealed for the first time. The emergence of multivortex instantaneous distributions of magnetization upon an increase in the film thickness and the external field intensity have been established. The dependence of the critical field on the film thickness has been refined.  相似文献   
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