Neuropsychological function in adults with attention-deficit hyperactivity disorder

Pacemaker therapy in patients with atrial fibrillation means the best current pacemaker therapy for patients with bradycardias with the aim to avoid the onset of atrial fibrillation and to establish DDD pacing despite of a history of atrial tachyarrhythmias. The newer application of pacing is the suppression of atrial arrhythmias in patients with medical refractory atrial tachyarrhythmias. Patients with slow ventricular rates and permanent atrial fibrillation should receive a VVI-pacemaker, if the bradycardias causes syncope, dizziness or a decrease of their exercise tolerance. In case of chronotropic incompetence the pacemaker should provide rate responsive pacing. Patients with sick sinus syndrome should receive an atrial (AAI) or dual-chamber (DDD) pacemaker, because patients with these in contrast to VVI-pacemakers develop less often atrial fibrillation and subsequent complications such as atrial thromboembolism. A dual-chamber or VDD-pacemaker--the latter connected to a VDD-single-lead--is indicated in patients with advanced AV-block. Atrial fibrillation occurs in 3 to 6% of the patients with no history of arrythmia and is, if pacemakers have no automatic mode switch, an often reason to program the devices to the VVI-pacing mode. Nowadays, most DDD(R)-pacemakers provide an automatic mode switch: During an atrial tachycardia the pacemaker switches to a VVI/VVIR mode and restores the initial DDD(R)-pacing mode with termination of the arrhythmia. In respect to the newer applications, one approach to prevent atrial tachyarrhythmias is permanent atrial pacing. As lower pacing rates of 80 to 90 ppm are usually needed and many patients hardly tolerate these pacing rates, new algorithms are under clinical investigation. Another approach is the simultaneous depolarization of the right and left atrium. Biatrial pacing is performed with one lead in the high right atrium and another lead in the coronary sinus. Another solution is bifocal atrial pacing with leads placed in the high right atrium and in the coronary sinus ostium. One effect of the new pacing techniques is to shorten interatrial conduction times. Therefore, biatrial pacing has become a therapy to prevent atrial arrhythmias deriving from delayed interatrial conduction times. As atrial reentry circuits seem to be important in atrial fibrillation, multisite atrial pacing is also performed in patients with medical refractory paroxysmal atrial fibrillation. Preliminary results suggest a more effective prevention of atrial fibrillation; nevertheless, these techniques should be still restricted to patients enrolled in clinical studies.     

Passive Three Dimensional Face Recognition Using Iso-Geodesic Contours and Procrustes Analysis

We introduce a new model for personal recognition based on the 3-D geometry of the face. The model is designed for application scenarios where the acquisition conditions constrain the facial position. The 3-D structure of a facial surface is compactly represented by sets of contours (facial contours) extracted around automatically pinpointed nose tip and inner eye corners. The metric used to decide whether a point on the face belongs to a facial contour is its geodesic distance from a given landmark. Iso-geodesic contours are inherently robust to head pose variations, including in-depth rotations of the face. Since these contours are extracted from rigid parts of the face, the resulting recognition algorithms are insensitive to changes in facial expressions. The facial contours are encoded using innovative pose invariant features, including Procrustean distances defined on pose-invariant curves. The extracted features are combined in a hierarchical manner to create three parallel face recognizers. Inspired by the effectiveness of region ensembles approaches, the three recognizers constructed around the nose tip and inner corners of the eyes are fused both at the feature-level and the match score-level to create a unified face recognition algorithm with boosted performance. The performances of the proposed algorithms are evaluated and compared with other algorithms from the literature on a large public database appropriate for the assumed constrained application scenario.     

The categories L-\mathbf{Top}_{0} and L-\mathbf{Sob} as epireflective hulls

We show that the category \(L\) - \(\mathbf{Top}_{0}\) of \(T_{0}\) - \(L\) -topological spaces is the epireflective hull of Sierpinski \(L\) -topological space in the category \(L\) - \(\mathbf{Top}\) of \(L\) -topological spaces and the category \(L\) - \(\mathbf{Sob}\) of sober \(L\) -topological spaces is the epireflective hull of Sierpinski \(L\) -topological space in the category \(L\) - \(\mathbf{Top}_{0}\) .     

Role of residual stresses induced by industrial fabrication on stress corrosion cracking susceptibility of austenitic stainless steel

Effect of residual stress generated during tube fabrication, roll expansion and machining of stainless steel on the stress corrosion cracking (SCC) susceptibility was studied by testing fabricated tubes, tube–tube sheet joint and heavily machined plate of austenitic stainless steel (SS) in boiling MgCl₂. U bend samples of machined plate were exposed to acidified SO₄ + Cl^? environment at room temperature to study its ambient temperature SCC behavior. The results correlate the SCC behavior of the SS tubes and roll expanded joints to the nature and magnitude of residual stresses present. The study also highlights the distinct difference in ambient temperature SCC behavior of machined vs. nonmachined surfaces.     

Crop Reference Evapotranspiration: A Discussion of the Concept,Analysis of the Process and Validation

The study at first recalls the concept of “potential evapotranspiration” (PET), originally considered equal to the evaporation climatic demand; then, it reminds the steps of its progressive evolution toward the concept of “reference crop evapotranspiration” (ET₀) determined on irrigated grass. A physical analysis conducted on the evaporation process is subsequently reported to help clarifying the links between ET₀ and evaporation climatic demand. This analysis clearly demonstrates that the equivalence of ET₀ to evaporation climatic demand is not correct, although still common assumption in recent scientific literature, particularly in hydrology. The study also identifies two processes acting in opposite directions in the dynamics of ET₀: (1) the climatic variables determining the evaporation demand, and (2) the canopy resistance which slows down the response of irrigated grass to such demand. The analysis of the respective impact of these two processes on ET₀ dynamics shows that the available energy is the dominant process. This variable takes into account the 60–70% of the variation of ET₀, both at hourly and daily scales, while canopy resistance only explains 10–20% of ET₀ variation of irrigated grass. The study regards different climatic situations. Possible effects on practical applications were also discussed in the conclusions, together with comments on the correct canopy resistance modelling.     

Network-aware heuristics for inter-domain meta-scheduling in Grids

Grid computing generally involves the aggregation of geographically distributed resources in the context of a particular application. As such resources can exist within different administrative domains, requirements on the communication network must also be taken into account when performing meta-scheduling, migration or monitoring of jobs. Similarly, coordinating efficient interaction between different domains should also be considered when performing such meta-scheduling of jobs. A strategy to perform peer-to-peer-inspired meta-scheduling in Grids is presented. This strategy has three main goals: (1) it takes the network characteristics into account when performing meta-scheduling; (2) communication and query referral between domains is considered, so that efficient meta-scheduling can be performed; and (3) the strategy demonstrates scalability, making it suitable for many scientific applications that require resources on a large scale. Simulation results are presented that demonstrate the usefulness of this approach, and it is compared with other proposals from literature.     

EAPB0503, an Imidazoquinoxaline Derivative Modulates SENP3/ARF Mediated SUMOylation,and Induces NPM1c Degradation in NPM1 Mutant AML

Nucleophosmin-1 (NPM1) is a pleiotropic protein involved in numerous cellular processes. NPM1 shuttles between the nucleus and the cytoplasm, but exhibits a predominant nucleolar localization, where its fate and functions are exquisitely controlled by dynamic post-translational modifications (PTM). Sentrin/SUMO Specific Peptidase 3 (SENP3) and ARF are two nucleolar proteins involved in NPM1 PTMs. SENP3 antagonizes ARF-mediated NPM1 SUMOylation, to promote ribosomal biogenesis. In Acute Myeloid Leukemia (AML), NPM1 is frequently mutated, and exhibits an aberrant cytoplasmic localization (NPM1c). NPM1c mutations define a separate AML entity with good prognosis in some AML patients, rendering NPM1c as a potential therapeutic target. SENP3-mediated NPM1 de-SUMOylation induces resistance to therapy in NPM1c AML. Here, we demonstrate that the imidazoquinoxaline EAPB0503 prolongs the survival and results in selective reduction in the leukemia burden of NPM1c AML xenograft mice. Indeed, EAPB0503 selectively downregulates HDM2 expression and activates the p53 pathway in NPM1c expressing cells, resulting in apoptosis. Importantly, we unraveled that NPM1c expressing cells exhibit low basal levels of SUMOylation paralleled with high SENP3 and low ARF basal levels. EAPB0503 reverted these molecular players by inducing NPM1c SUMOylation and ubiquitylation, leading to its proteasomal degradation. EAPB0503-induced NPM1c SUMOylation is concurrent with SENP3 downregulation and ARF upregulation in NPM1c expressing cells. Collectively, these results provide a strong rationale for testing therapies modulating NPM1c post-translational modifications in the management of NPM1c AML.     

Effect of tanniniferous Terminalia chebula extract on rumen biohydrogenation, ∆(9)-desaturase activity, CLA content and fatty acid composition in longissimus dorsi muscle of kids

Conjugated linoleic acid, a fatty acid found in milk fat and ruminant meat is one of the functional food components. Modifying fatty acid composition so as to increase CLA and other beneficial PUFA/MUFA level and reducing SFA levels might be a key to enhance the neutraceutical and therapeutic value of ruminant-derived food products. In the present experiment, the effect of supplementation of polyphenol rich Terminalia chebula plant extract at different concentrations (1.06 g/kg and 3.18 g/kg of body weight in T1 and T2 groups, respectively) was investigated on fatty acid composition of rumen fluid, plasma, intramuscular fat and Δ9-desaturase activity in longissimus dorsi muscle of crossbred kids. Total MUFA and PUFA content in muscle were enhanced by 25 and 35%, respectively, whereas SFA was reduced by 20% thereby improving the desaturation index. Δ9-desaturase activity also increased by 47% resulting in an enhancement of total CLA content (58.73%) in muscle.