Industry case study: rapid prototype of mountain bike frame section

The purpose of this study is to detail a virtual and physical prototyping process to overcome a design constraint in the mountain bike industry. Through a series of techniques, 3D scanning, developing detailed CAD models, then through additive manufacturing processes, a solution was developed. The challenge in the industry is the constant geometrical changes of components; the trend has been that bike cranks are becoming narrower due to biomechanical factors and tyres are becoming wider due to rider preferences and increased grip. This change in geometry results in metal tubes that can no longer be deformed without exceeding the minimum bend radius for the material. As such exceeding the minimum bend radius will induce early performance failure and geometrical (aesthetic) defects. The solution is an additive manufactured part that can be substituted into the process without disrupting the entire conventional build process of a customised bike build.     

A utility-driven approach to supplier evaluation and selection: empirical validation of an integrated solution framework

Supplier evaluation and selection (SES) problems have long been studied, leading to the development of a wide range of individual and hybrid models for solving them. However, the lack of widespread diffusion of existing SES models in the industry points to a need for simpler models that can systematically evaluate both qualitative and quantitative attributes of potential suppliers while enhancing the flexibility decision-makers need to account for relevant situational factors. Furthermore, empirical validations of existing models in SES have been few and far between. With a view to addressing these issues, this paper proposes an integrated solution framework that can be used to evaluate both tangible and intangible attributes of potential suppliers. The proposed framework combines three individual methods, namely the fuzzy analytic hierarchy process, fuzzy complex proportional assessment and fuzzy linear programming. The framework is validated through application in a Turkish textile company. The results generated using the proposed framework is compared with the actual historical data collected from the company. Additionally, a feasibility assessment is conducted on the sample supplier selection criteria employed, as well as assessment of the results generated using the proposed model.     

Estimation of bias with the single‐zone assumption in measurement of residential air exchange using the perfluorocarbon tracer gas method

Residential air exchange rates (AERs) are vital in understanding the temporal and spatial drivers of indoor air quality (IAQ). Several methods to quantify AERs have been used in IAQ research, often with the assumption that the home is a single, well‐mixed air zone. Since 2005, Health Canada has conducted IAQ studies across Canada in which AERs were measured using the perfluorocarbon tracer (PFT) gas method. Emitters and detectors of a single PFT gas were placed on the main floor to estimate a single‐zone AER (AER_1z). In three of these studies, a second set of emitters and detectors were deployed in the basement or second floor in approximately 10% of homes for a two‐zone AER estimate (AER_2z). In total, 287 daily pairs of AER_2z and AER_1z estimates were made from 35 homes across three cities. In 87% of the cases, AER_2z was higher than AER_1z. Overall, the AER_1z estimates underestimated AER_2z by approximately 16% (IQR: 5–32%). This underestimate occurred in all cities and seasons and varied in magnitude seasonally, between homes, and daily, indicating that when measuring residential air exchange using a single PFT gas, the assumption of a single well‐mixed air zone very likely results in an under prediction of the AER.     

Assessment of palatability attributes of the major beef muscles

One kilogram roasts from 33 muscles or muscle groups from 25 Canada AA steer carcasses were evaluated for palatability after roasting to 72?°C internal temperature in an electric convection oven preheated to 177?°C. Initial tenderness ranged from moderately tough to tender. All butt tender and tenderloin samples were tender on the first bite, but less than 10% of the rib cap (top and lower portions), deckle point, brisket, and eye of round samples were rated tender on the first bite. Overall tenderness also ranged from moderately tough to tender. All of the tenderloin, butt tender, rib-eye cap, and cross rib samples were rated tender overall, but none of the deckle point samples were rated tender overall. Perceptible connective tissue ranged from slight to moderately abundant. Juiciness ranged from slightly dry to moderately juicy. All of the tenderloin, cross rib cap, rib-eye cap, tri tip, flap meat, short rib, and skirt samples were rated juicy, but 40% or less of the shoulder, eye of round, and loss side samples were rated juicy. Beef flavor intensity ranged from slightly to moderately intense, and flavor desirability ranged from slightly undesirable to moderately desirable. All tenderloin, butt tender, striploin, rib-eye, and cross rib cap samples were rated desirable in overall palatability, but 25% or less of the rib cap (top and lower portions), shank meat, eye of round, brisket, and deckle point samples were rated desirable in overall palatability. To the extent desirability to the panel utilized is representative of consumer acceptance, only the tenderloin, butt tender, rib-eye cap, cross rib, cross rib cap, and rib-eye either met or came close to meeting the Canadian Cattlemen's Association's goal of 95% acceptance based upon palatability. Consequently, effective postmortem intervention techniques or alternative cooking methods must be developed and applied to improve the palatability of most beef muscles, if the aforementioned goal is to be achieved.     

34S/32S fractionation during sulfate reduction in groundwater treatment systems: reactive transport modeling

Isotope ratio measurements provide a tool for indicating the relative significance of biogeochemical reactions and for constraining estimates of the extent and rate of reactions in passive treatment systems. In this paper, the reactive transport model MIN3P is used to evaluate sulfur isotope fractionation in column experiments designed to simulate treatment of contaminated water by microbially mediated sulfate reduction occurring within organic carbon-based and iron and carbon-based permeable reactive barriers. A mass dependent fractionation model was used to determine reaction rates for 32S and 34S compounds during reduction, precipitation, and dissolution reactions and to track isotope-dependent mass transfer during SO4 removal. The δ34S values obtained from the MIN3P model were similar to those obtained from the Rayleigh equation, indicating that there was not a significant difference between the conceptual models. Differences between the MIN3P derived α value and the Rayleigh equation derived value were attributed to minor changes in the dissolution and precipitation rate of gypsum and mathematical differences in the fitting models. The results indicated that the prediction of δ34S was fairly insensitive to differences in the fractionation factor at the concentration ranges measured in the current study. However, more significant differences would be expected at low sulfate conditions.     

Imidazolium Polyesters: Structure–Property Relationships in Thermal Behavior,Ionic Conductivity,and Morphology

New bis(ω‐hydroxyalkyl)imidazolium and 1,2‐bis[N‐(ω‐hydroxyalkyl)imidazolium]ethane salts are synthesized and characterized; most of the salts are room temperature ionic liquids. These hydroxyl end‐functionalized ionic liquids are polymerized with diacid chlorides, yielding polyesters containing imidazolium cations embedded in the main chain. By X‐ray scattering, four polyesters are found to be semicrystalline at room temperature: mono‐imidazolium‐C₁₁‐sebacate‐C₆ ( 4e ), mono‐imidazolium‐C₁₁‐sebacate‐C₁₁ ( 4c ), bis(imidazolium)ethane‐C₆‐sebacate‐C₆ ( 5a ), and bis(imidazolium)ethane‐C₁₁‐sebacate‐C₁₁ ( 5c ), all with hexafluorophosphate counterions. The other imidazolium polyesters, including all those with bis(trifluoromethanesulfonyl)imide (TFSI^?) counterions, are amorphous at room temperature. Room temperature ionic conductivities of the mono‐imidazolium polyesters (4 × 10^?6 to 3 × 10^?5 S cm^?1) are higher than those of the corresponding bis‐imidazolium polyesters (4 × 10^?9 to 8 × 10^?6 S cm^?1), even though the bis‐imidazolium polyesters have higher ion concentrations. Counterions affect ionic conduction significantly; all polymers with TFSI^? counterions have higher ionic conductivities than the hexafluorophosphate analogs. Interestingly, the hexafluorophosphate polyester, 1,2‐bis(imidazolium)ethane‐C₁₁‐sebacate‐C₁₁ ( 5c ), displays almost 400‐fold higher room temperature ionic conductivity (1.6 × 10^?6 S cm^?1) than the 1,2‐bis(imidazolium)ethane‐C₆‐sebacate‐C₆ analog ( 5a , 4.3 × 10^?9 S cm^?1), attributable to the differences in the semicrystalline structure in 5c as compared to 5a . These results indicate that semicrystalline polymers may result in high ionic conductivity in a soft (low glass tranition temperature, T_g) amorphous phase and good mechanical properties of the crystalline phase.     

Engineering, characterization and directional self-assembly of anisotropically modified nanocolloids

Along with traditional attributes such as the size, shape, and chemical structure of polymeric micro-objects, control over material distribution, or selective compartmentalization, appears to be increasingly important for maximizing the functionality and efficacy of biomaterials. The fabrication of tri- and tetracompartmental colloids made from biodegradable poly(lactide-co-glycolide) polymers via electrohydrodynamic co-jetting is demonstrated. The presence of three compartments is confirmed via flow cytometry. Additional chemical functionality is introduced via the incorporation of acetylene-functionalized polymers into individual compartments of the particles. Direct visualization of the spatioselective distribution of acetylene groups is demonstrated by confocal Raman microscopy as well as by reaction of the acetylene groups with azide-biotin via 'click chemistry'. Biotin-streptavidin binding is then utilized for the controlled assembly and orientation of bicompartmental particles onto functionalized, micropatterned substrates prepared via chemical vapor deposition polymerization.     

Fluorescence sensing of zinc(II) using ordered mesoporous silica material (MCM-41) functionalized with N-(quinolin-8-yl)-2-[3-(triethoxysilyl)propylamino]acetamide

A novel fluorescent zinc sensor was designed and synthesized on ordered mesoporous silica material, MCM-41, with N-(quinolin-8-yl)-2-[3-(triethoxysilyl)propylamino]acetamide (QTEPA; 3) using a simple one-step molecular self-assembly of the silane. The solution and solid samples were characterized using solid-state nuclear magnetic resonance, transmission electron microscopy, diffuse-reflectance infrared Fourier transform, and thermogravimetric analysis techniques. The QTEPA-modified MCM-41 (4) shows 3-fold fluorescence emission enhancement and about a 55 nm red shift upon addition of 1 μM Zn(II) ions in a Tris-HCl (pH 7.22) aqueous buffer solution. The UV-vis absorption maximum is at 330 ± 5 nm, and the fluorescence emission maximum wavelength is at 468 nm, with an increase in quantum yield from 0.032 to 0.106 under the same conditions. The presence of other metal ions has no observable effect on the sensitivity and selectivity of 4. This system selectively detects Zn(II) ions with submicromolar detection to a limit of 0.1 μM. The MCM-41-based systems have the advantage that they can be employed in aqueous solutions without any aggregation.     

The contact resistance for a semi-infinite cylinder in a vacuum

The flow of heat between solid bodies in contact is considered. An exact method of approach to the problem of a single idealised contact is given which involves the reduction of the mixed boundary value problem to a Fredholm integral equation. This integral equation is solved by a standard procedure. An expression for the thermal contact resistance is given.     

A 3D In Vitro Cancer Model as a Platform for Nanoparticle Uptake and Imaging Investigations

In order to maximize the potential of nanoparticles (NPs) in cancer imaging and therapy, their mechanisms of interaction with host tissue need to be fully understood. NP uptake is known to be dramatically influenced by the tumor microenvironment, and an imaging platform that could replicate in vivo cellular conditions would make big strides in NP uptake studies. Here, a novel NP uptake platform consisting of a tissue‐engineered 3D in vitro cancer model (tumoroid), which mimics the microarchitecture of a solid cancer mass and stroma, is presented. As the tumoroid exhibits fundamental characteristics of solid cancer tissue and its cellular and biochemical parameters are controllable, it provides a real alternative to animal models. Furthermore, an X‐ray fluorescence imaging system is developed to demonstrate 3D imaging of GNPs and to determine uptake efficiency within the tumoroid. This platform has implications for optimizing the targeted delivery of NPs to cells to benefit cancer diagnostics and therapy.