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91.
92.
J Stagsted S Ziebe S Satoh GD Holman SW Cushman L Olsson 《Canadian Metallurgical Quarterly》1993,268(3):1770-1774
Peptides derived from the alpha 1-region of the murine H-2Dk molecule enhance glucose uptake in rat adipose cells above the maximum obtained with insulin stimulation alone (Stagsted, J., Reaven, G. M., Hansen, T., Goldstein, A., and Olsson, L. (1990) Cell 62, 297-307). We now describe that epidermal growth factor (EGF) in combination with the same peptides, Dk-(61-85) and Dk-(62-85), stimulates cellular glucose uptake 5-7 times over the basal level, i.e. to 30-50% of the maximal insulin effect. EGF alone increased glucose uptake by only approximately 50% above basal and the peptide alone by 100% above basal. Maximal effect of EGF and peptide was reached in 10-20 min with 30 microM peptide (EC50 10-15 microM) and 50 nM EGF (EC50 1-2 nM). The effect of EGF and peptide on glucose uptake was additive to that of insulin and peptide until the maximal level attained with insulin and peptide was reached. The combined effect of EGF plus peptide on glucose transport was associated with a recruitment of GLUT4 molecules to the plasma membrane. However, the phosphatidylinositol (PI) kinase which is activated by insulin was not activated by EGF plus peptide. Thus, the effect of EGF plus peptide on glucose uptake seems independent of the activity status of the insulin receptor. 125I-Labeled EGF bound specifically to rat adipose cells with an apparent affinity of approximately 2 nM and Bmax approximately 5 x 10(3). However, the major histocompatibility complex (MHC) peptides did not affect EGF-stimulated internalization of EGF receptor, in contrast to their effect on the insulin receptors. Transforming growth factor alpha had an effect similar to EGF on glucose uptake. Three other peptides derived from other parts of murine MHC class I had no effect on glucose uptake in combination with EGF. Thus, EGF in combination with certain MHC class I-derived peptides is insulinomimetic concerning glucose transport and this effect is independent of the insulin receptor activity. 相似文献
93.
The objective is to have uniformly distributed tangential stresses on the transition profile of a stepped bar subjected to tensile and torsional loading using an axisymmetric boundary element formulation. The transition curve is represented by the Langragian interpolation polynomial with progressive degrees to avoid shape distortion during the optimization procedure. The calculated result is compared with that obtained by fluid dynamics given in the literature. It is seen that the transition curve obtained in this paper is reasonable. 相似文献
94.
Particulate TiB2 reinforced aluminum-based metal matrix composites (MMCs) were successfully fabricated by means of the reaction processing
method. TiB2 particulates were formed in situ through the reaction of Ti and B in Ti-Al-B, TiO2 and B in TiO2-Al-B, and TiO2 and B2O3 in TiO2-Al-B2O3 systems. The results showed that in situ TiB2 particulates formed in the Ti-Al-B system had a size of 5 μm and they exhibited block and rodlike structures. Moreover, coarse Al3Ti blocks several tens of micrometers in size were also formed simultaneously. On the other hand, equiaxed Al2O3 and TiB2 particulates with a size of less than 2 μm were formed in situ in the TiO2-Al-B and TiO2-Al-B2O3 systems. The Al3Ti phase was completely eliminated in the TiO2-Al-B system with increasing B content. Tensile tests revealed that the Al2O3 · TiB2/Al composite fabricated from the TiO2-Al-B system exhibits excellent mechanical properties. The yield strength of the Al2O3 · TiB2/Al composite appeared to increase with increasing TiB2 content. The yield strength of the Al2O3 · TiB2/Al composite could be further increased by introducing CuO into the TiO2-Al-B system. Such an increment in mechanical strength arose from the strengthening effect caused by the Al2Cu precipitates. The incorporation of CuO had no effect on the in situ reaction process of the TiO2-Al-B system. Finally, the effect of SiC addition on the microstructure and mechanical properties of the composites fabricated
from the TiO2-Al-B and TiO2-Al-B-CuO systems was also investigated. 相似文献
95.
Control of peak sidelobe level in adaptive arrays 总被引:1,自引:0,他引:1
Renbiao Wu Zheng Bao Yuanliang Ma 《Antennas and Propagation, IEEE Transactions on》1996,44(10):1341-1347
Adaptive beamforming techniques are now widely used to reject interference (jammer/clutter) signals in radar, communication, and sonar applications. In adaptive arrays using the sample matrix inversion (SMI) algorithm, inadequate estimation of the covariance matrix results in adaptive antenna patterns with high sidelobes and distorted mainbeams. In this paper, a method is proposed to precisely control the peak (rather than average) sidelobe level of adaptive array patterns. The proposed method is also generalized to adaptive array antennas with moderate bandwidth and large random amplitude and phase errors. Theoretical analysis and simulation results are provided to illustrate the performance of the method proposed 相似文献
96.
本文讨论了一个具有通用性的测试评估软件生成系统的设计思想和实现方法,给出了该生成器的系统组成、数据组织结构、查询搜索方式以及用户界面的设计。该系统具广泛的应用领域和实用意义。 相似文献
97.
We present the design of E-kernel, an embedding kernel on the Victor V256 message-passing partitionable multiprocessor, developed for the support of program mapping and network reconfiguration. E-kernel supports the embedding of a new network topology onto Victor's 2D mesh and also the embedding of a task graph onto the 2D mesh network or the reconfigured network. In the current implementation, the reconfigured network can be a line or an even-size ring, and the task graphs meshes or tori of a variety of dimensions and shapes or graphs with similar topologies. For application programs having these task graph topologies and that are designed according to the communication model of E-kernel, they can be run without any change on partitions connected by the 2D mesh, line, or ring. Further, E-kernel attempts the communication optimization of these programs on the different networks automatically, thus making both the network topology and the communication optimization attempt completely transparent to the application programs. Many of the embeddings used in E-kernel are optimal or asymptotically optimal (with respect to minimum dilation cost). The implementation of E-kernel translated some of the many theoretical results in graph embeddings into practical tools for program mapping and network reconfiguration in a parallel system. E-kernel is functional on Victor V256. Measurements of E-kernel's performance on V256 are also included 相似文献
98.
子波变换理论及其在信号处理中的应用 总被引:4,自引:0,他引:4
子波分析的形成是傅里叶分析发展史上里程碑式的进展,子波分析优于傅里叶交换的地方在于它在时域和频域同时具有良好的局部化性质,从而可以把分析的重点聚焦到任意的细节,被人们誉为数学显微镜,成为近年来在工具和方法上的重大突破。本文将子波理论中的主要定理、结论、变换特性和一些重要概念加以综述,以促进子波理论的应用。本文的重点在于介绍多分辨率分析和子波分析及其实现、子波变换及其算法、子波和滤波器组等的重要内容,并介绍其在信号处理中的应用及研究动态。 相似文献
99.
The objectives of this study were to evaluate the possible mechanisms involved in prolongation of bleeding time in pre-eclamptic patients receiving a magnesium sulfate infusion to prevent convulsions. Eighteen pre-eclamptic patients near term or at term (4 cases 33 to 35 weeks; the remainder > 36 weeks) were studied. Fifteen of them received magnesium sulfate infusion; 3 did not and served as controls. Bleeding time (modified Ivy method with Surgicutt), platelet count, platelet aggregation pattern, as well as serum arachidonic acid metabolites [thromboxane B2 (TxB2) and 6-Keto-prostaglandin F1 alpha (6-Keto-PGF1 alpha)] werde done on admission to the labor floor (before magnesium infusion) and repeated at discontinuation of the infusion, 12-24 hours postpartum; the controls received the second test 24 hours postpartum. Thirteen of 15 patients receiving magnesium sulfate had an increase in bleeding time from an average of 6 minutes 31 seconds to 11 minutes 56 seconds, an 82% rise (p < 0.004). In 2 there was a decrease. Among the 3 controls the averages were 6 minutes 38 seconds and 6 minutes 3 seconds. The total magnesium given ranged from 52.5 to 145 grams. Platelet counts averaged 251,000/mm3 (range 145,000-519,000). Platelet aggregation pattern done in 11 patients and was normal and unchanged after magnesium in 10 of the patients with increased bleeding time and one control. TxB2 and 6-Keto-PGF1 alpha levels did not change significantly either after magnesium administration (688 and 135 pgm/ml, to 654 and 117) or in controls (695 and 230 pgm/ml, to 445 and 225). Likewise, the ratio of these 2 substances did not change in either group (6.3 to 6.6, and 4.2 to 2.2). There was no correlation between duration of infusion or total magnesium given and directions of small changes observed. This study confirms a prior preliminary observation that magnesium sulfate infusion, as currently used to prevent eclamptic convulsions, induces a significant prolongation of bleeding time. This effect is mediated neither by changes in platelets count or aggregation pattern, nor by changing the level or ratios of serum arachidonic acid metabolites (TxB2 and 6-Keto-PGF1 alpha). Further studies are needed to clarify the mechanism of this clinically important observation of increased bleeding following magnesium sulfate infusion. 相似文献
100.
In this paper,a sequential algorithm computing the aww vertex pair distance matrix D and the path matrix Pis given.On a PRAM EREW model with p,1≤p≤n^2,processors,a parallel version of the sequential algorithm is shown.This method can also be used to get a parallel algorithm to compute transitive closure array A^* of an undirected graph.The time complexity of the parallel algorithm is O(n^3/p).If D,P and A^* are known,it is shown that the problems to find all connected components,to compute the diameter of an undirected graph,to determine the center of a directed graph and to search for a directed cycle with the minimum(maximum)length in a directed graph can all be solved in O(n^2/p logp)time. 相似文献