Synthesis and in vivo evaluation of a 99m/99Tc-DADT-benzovesamicol: a potential marker for cholinergic neurons

Fifty-six asthmatics from an asthma ward or from an asthma out-patient clinic were challenged with two low concentrations (0.03 and 0.012 mg) of metacholine chloride in order to assess the relationship between pronounced hyper-responsiveness and asthma severity in a clinical setting. Only inhaled bronchodilators were stopped before challenge. Asthma severity was assessed retrospectively and prospectively on the basis of treatment, number of days in hospital, intensive care, number of emergency visits and days on sick-leave. The results show that pronounced hyper-responsiveness (n = 28) is not associated with asthma severity. It is concluded that a single simplified test of pronounced bronchial hyper-responsiveness, performed without taking into consideration the actual state of the disease and without stopping all medication, is of no help in identifying the patients with the clinically most severe asthma and worst prognosis.     

用于工业牵引的软穿通IGBT技术大功率模块

随着1.7 kV SPT(软穿通)IGBT LoPak密集型封装结构模块类型的引入,为进一步开发利用新的1.7 kV SPTIGBT和二极管芯片的特性,研发了电压为1.7kV,电流额定值为2.4 kA新封装类型的模块,该模块采用了E1和E2工业标准模块封装形式.在长期高可靠性应用的经验基础上,设计了新的封装类型,其特性适用于牵引市场.讨论了1.7 kV SPT IGBT(E1/E2)模块范围的特性,尤其论述了改进的静态和动态特性.