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121.
Salvatore Vittorio 《中国集成电路》2008,17(12):58-65
1加密技术-综述
我讲话时总是被窃听,这是隐私,请从我的电话线上走开!请告诉我什么时候我才能有隐私。一Ray Davies和Dave Davies(这是英国摇滚乐队The Kinks的戴维斯兄弟所写的歌词) 相似文献
122.
123.
Massimo Dal Monte Maurizio Cammalleri Rosario Amato Salvatore Pezzino Roberta Corsaro Paola Bagnoli Dario Rusciano 《International journal of molecular sciences》2020,21(23)
Melatonin is of great importance for regulating several eye processes, including pressure homeostasis. Melatonin in combination with agomelatine has been recently reported to reduce intraocular pressure (IOP) with higher efficacy than each compound alone. Here, we used the methylcellulose (MCE) rat model of hypertensive glaucoma, an optic neuropathy characterized by the apoptotic death of retinal ganglion cells (RGCs), to evaluate the hypotensive and neuroprotective efficacy of an eye drop nanomicellar formulation containing melatonin/agomelatine. Eye tissue distribution of melatonin/agomelatine in healthy rats was evaluated by HPLC/MS/MS. In the MCE model, we assessed by tonometry the hypotensive efficacy of melatonin/agomelatine. Neuroprotection was revealed by electroretinography; by levels of inflammatory and apoptotic markers; and by RGC density. The effects of melatonin/agomelatine were compared with those of timolol (a beta blocker with prevalent hypotensive activity) or brimonidine (an alpha 2 adrenergic agonist with potential neuroprotective efficacy), two drugs commonly used to treat glaucoma. Both melatonin and agomelatine penetrate the posterior segment of the eye. In the MCE model, IOP elevation was drastically reduced by melatonin/agomelatine with higher efficacy than that of timolol or brimonidine. Concomitantly, gliosis-related inflammation and the Bax-associated apoptosis were partially prevented, thus leading to RGC survival and recovered retinal dysfunction. We suggest that topical melatoninergic compounds might be beneficial for ocular health. 相似文献
124.
Neil Gerard Quigley Dr. Stefano Tomassi Dr. Francesco Saverio di Leva Dr. Salvatore Di Maro Dr. Frauke Richter Dr. Katja Steiger Prof. Dr. Susanne Kossatz Prof. Dr. Luciana Marinelli Dr. Johannes Notni 《Chembiochem : a European journal of chemical biology》2020,21(19):2836-2843
αvβ6 Integrin is an epithelial transmembrane protein that recognizes latency-associated peptide (LAP) and primarily activates transforming growth factor beta (TGF-β). It is overexpressed in carcinomas (most notably, pancreatic) and other conditions associated with αvβ6 integrin-dependent TGF-β dysregulation, such as fibrosis. We have designed a trimeric Ga-68-labeled TRAP conjugate of the αvβ6-specific cyclic pentapeptide SDM17 (cyclo[RGD-Chg-E]-CONH2) to enhance αvβ6 integrin affinity as well as target-specific in-vivo uptake. Ga-68-TRAP(SDM17)3 showed a 28-fold higher αvβ6 affinity than the corresponding monomer Ga-68-NOTA-SDM17 (IC50 of 0.26 vs. 7.4 nM, respectively), a 13-fold higher IC50-based selectivity over the related integrin αvβ8 (factors of 662 vs. 49), and a threefold higher tumor uptake (2.1 vs. 0.66 %ID/g) in biodistribution experiments with H2009 tumor-bearing SCID mice. The remarkably high tumor/organ ratios (tumor-to-blood 11.2; -to-liver 8.7; -to-pancreas 29.7) enabled high-contrast tumor delineation in PET images. We conclude that Ga-68-TRAP(SDM17)3 holds promise for improved clinical PET diagnostics of carcinomas and fibrosis. 相似文献
125.
Ludi Xu Degui Zhu Yunlong Liu Tohru S. Suzuki Byung-nam Kim Yoshio Sakka Salvatore Grasso Chunfeng Hu 《Journal of the European Ceramic Society》2018,38(10):3417-3423
Oxidation resistance of textured Ti3AlC2 ceramics was measured in the temperature range 1273–1573?K. It was found that the oxidation was markedly anisotropic and the samples exhibited a better oxidation resistance when tested along a direction transverse to the c-axis. This behavior was attributed to the rapid diffusion of Al within its basal planes to form a passivating Al2O3 scale and it respected Ellingham diagrams. The scales formed had different compositions depending on the testing direction; this response was clearly resulting from the crystallographic orientation. Even at 1473?K after 20?h exposure, the samples tested in a direction transverse to the c-axis showed a reduced weight gain which was 45 times lower than one seen on a basal plane. 相似文献
126.
Nicola Alessio Domenico Aprile Salvatore Cappabianca Gianfranco Peluso Giovanni Di Bernardo Umberto Galderisi 《International journal of molecular sciences》2021,22(6)
During their life span, cells have two possible states: a non-cycling, quiescent state (G0) and a cycling, activated state. Cells may enter a reversible G0 state of quiescence or, alternatively, they may undergo an irreversible G0 state. The latter may be a physiological differentiation or, following a stress event, a senescent status. Discrimination among the several G0 states represents a significant investigation, since quiescence, differentiation, and senescence are progressive phenomena with intermediate transitional stages. We used the expression of Ki67, RPS6, and beta-galactosidase to identify healthy cells that progressively enter and leave quiescence through G0-entry, G0 and G0-alert states. We then evaluated how cells may enter senescence following a genotoxic stressful event. We identified an initial stress stage with the expression of beta-galactosidase and Ki67 proliferation marker. Cells may recover from stress events or become senescent passing through early and late senescence states. Discrimination between quiescence and senescence was based on the expression of RPS6, a marker of active protein synthesis that is present in senescent cells but absent in quiescent cells. Even taking into account that fixed G0 states do not exist, our molecular algorithm may represent a method for identifying turning points of G0 transitional states that continuously change. 相似文献
127.
Gianmarco Mangiaterra Elisa Carotti Salvatore Vaiasicca Nicholas Cedraro Barbara Citterio Anna La Teana Francesca Biavasco 《International journal of molecular sciences》2021,22(4)
The occurrence of Pseudomonas aeruginosa (PA) persisters, including viable but non-culturable (VBNC) forms, subpopulations of tolerant cells that can survive high antibiotic doses, is the main reason for PA lung infections failed eradication and recurrence in Cystic Fibrosis (CF) patients, subjected to life-long, cyclic antibiotic treatments. In this paper, we investigated the role of subinhibitory concentrations of different anti-pseudomonas antibiotics in the maintenance of persistent (including VBNC) PA cells in in vitro biofilms. Persisters were firstly selected by exposure to high doses of antibiotics and their abundance over time evaluated, using a combination of cultural, qPCR and flow cytometry assays. Two engineered GFP-producing PA strains were used. The obtained results demonstrated a major involvement of tobramycin and bacterial cell wall-targeting antibiotics in the resilience to starvation of VBNC forms, while the presence of ciprofloxacin and ceftazidime/avibactam lead to their complete loss. Moreover, a positive correlation between tobramycin exposure, biofilm production and c-di-GMP levels was observed. The presented data could allow a deeper understanding of bacterial population dynamics during the treatment of recurrent PA infections and provide a reliable evaluation of the real efficacy of the antibiotic treatments against the bacterial population within the CF lung. 相似文献
128.
Salvatore Pontarelli Marco Bonola Giuseppe Bianchi 《International Journal of Network Management》2019,29(1)
Recently, with new hardware architectures such as Reconfigurable Match Tables and languages such as P4, the Software Defined Networking community has started to bring line‐rate data plane programmability inside switching chipsets. Starting from the original OpenFlow's match/action abstraction, most of the work has so far focused on key improvements in matching flexibility. Conversely, the “action part,” ie, the set of operations (such as encapsulation or header manipulation) performed on packets after the forwarding decision, has received way less attention. Goal of this paper is to move beyond the idea of “atomic,” preimplemented, actions, and rather make them programmable while retaining high speed multi‐Gbps operation. To this purpose, we propose a domain‐specific HW architecture, called Packet Manipulation Processor (PMP), able to efficiently implement such actions. Both a PMP C++ instruction set simulator and a NetFPGA prototype have been developed. The performances of the PMP have been verified with three nontrivial use cases (tunneling, NAT, and ARP reply generation), showing that also in the worst case the throughput is well above 10 Gbps. 相似文献
129.
Lo Sciuto Grazia Kałużyński Piotr Coco Salvatore 《Journal of Materials Science: Materials in Electronics》2022,33(8):5037-5048
Journal of Materials Science: Materials in Electronics - In this paper, chemiresistor sensor based on conductive polymer (regio-regular poly(3- hexyltiophene) (rr-P3HT) and zinc oxide (ZnO)... 相似文献
130.