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21.
Thermal comfort and use of thermostats in homes and office rooms were examined by a quantitative interview survey with a nationally representative sample in Finland. The total number of respondents was 3094. The results show that thermal comfort levels are lower in offices than in homes. People feel cold and hot more often in offices than in homes during both the winter and summer seasons. The perceived control over room temperature is remarkably low in offices. Higher thermal comfort levels and perceived control in homes are supported by greater adaptive opportunities. In offices people have fewer opportunities to control the thermal environment, people deal worse with thermostats, and people have lower opportunities to adapt to different thermal environments.  相似文献   
22.
    
Indium tin oxide (ITO) is a transparent conducting material that is widely used in devices where high transparency of the electrodes is required, such as flat panel and liquid crystal displays, touch panels, smart windows, and many others. ITO layers are deposited on a large scale by magnetron sputtering and then structured by lithography to define desired patterns of transparent electrodes. Here, a method for direct printing of transparent conductive patterns from ITO nanoparticle ink is communicated. The method combines inkjet printing with fast flash lamp annealing whereby the main novelty is to use an additional layer of a colored organic dye onto printed ITO to increase light absorption. The dye coating is instantly heated together with the underlying ITO layer by a light pulse, leading to an instant rise of the surface temperature, which is translated into improved optoelectronic properties of the ITO layers. Inkjet‐printed ITO patterns processed with the dye‐assisted flash lamp annealing exhibit a transmittance of up to 88% at 550 nm and resistivity of 3.1 × 10−3 Ω cm. Transparent touch‐sensing trackpad and capacitive touch sensors are demonstrated based on the printed ITO patterns, which can be utilized in transparent security systems and other transparent Internet‐of‐Things devices.  相似文献   
23.
    
Breast cancer is a diverse disease caused by mutations in multiple genes accompanying epigenetic aberrations of hazardous genes and protein pathways, which distress tumor-suppressor genes and the expression of oncogenes. Alteration in any of the several physiological mechanisms such as cell cycle checkpoints, DNA repair machinery, mitotic checkpoints, and telomere maintenance results in genomic instability. Theranostic has the potential to foretell and estimate therapy response, contributing a valuable opportunity to modify the ongoing treatments and has developed new treatment strategies in a personalized manner. “Omics” technologies play a key role while studying genomic instability in breast cancer, and broadly include various aspects of proteomics, genomics, metabolomics, and tumor grading. Certain computational techniques have been designed to facilitate the early diagnosis of cancer and predict disease-specific therapies, which can produce many effective results. Several diverse tools are used to investigate genomic instability and underlying mechanisms. The current review aimed to explore the genomic landscape, tumor heterogeneity, and possible mechanisms of genomic instability involved in initiating breast cancer. We also discuss the implications of computational biology regarding mutational and pathway analyses, identification of prognostic markers, and the development of strategies for precision medicine. We also review different technologies required for the investigation of genomic instability in breast cancer cells, including recent therapeutic and preventive advances in breast cancer.  相似文献   
24.
    
Emotional stress is believed to be associated with increased tumor progression. Stress-induced epigenetic modifications can contribute to the severity of disease and poor prognosis in cancer patients. The current study aimed to investigate the expression profiles along with the prognostic significance of psychological stress-related genes in metastatic breast cancer patients, to rationalize the molecular link between emotional stress and cancer progression. We profiled the expression of selected stress-associated genes (5-HTT, NR3C1, OXTR, and FKBP5) in breast cancer including the stress evaluation of all participants using the Questionnaire on Distress in Cancer Patients–short form (QSC-R10). A survival database, the Kaplan–Meier Plotter, was used to explore the prognostic significance of these genes in breast cancer. Our results showed relatively low expressions of 5-HTT (p = 0.02) and OXTR (p = 0.0387) in metastatic breast cancer patients as compared to the non-metastatic group of patients. The expression of NR3C1 was low in tumor grade III as compared to grade II (p = 0.04). Additionally, the expression of NR3C1 was significantly higher in patients with positive estrogen receptor status. However, no significant difference was found regarding FKBP5 expression in breast cancer. The results suggest a potential implication of these genes in breast cancer pathology and prognosis.  相似文献   
25.
    
Aurora kinase B (AKB) is a crucial signaling kinase with an important role in cell division. Therefore, inhibition of AKB is an attractive approach to the treatment of cancer. In the present work, extensive quantitative structure–activity relationships (QSAR) analysis has been performed using a set of 561 structurally diverse aurora kinase B inhibitors. The Organization for Economic Cooperation and Development (OECD) guidelines were used to develop a QSAR model that has high statistical performance (R2tr = 0.815, Q2LMO = 0.808, R2ex = 0.814, CCCex = 0.899). The seven-variable-based newly developed QSAR model has an excellent balance of external predictive ability (Predictive QSAR) and mechanistic interpretation (Mechanistic QSAR). The QSAR analysis successfully identifies not only the visible pharmacophoric features but also the hidden features. The analysis indicates that the lipophilic and polar groups—especially the H-bond capable groups—must be present at a specific distance from each other. Moreover, the ring nitrogen and ring carbon atoms play important roles in determining the inhibitory activity for AKB. The analysis effectively captures reported as well as unreported pharmacophoric features. The results of the present analysis are also supported by the reported crystal structures of inhibitors bound to AKB.  相似文献   
26.
It was hypothesized that human mesenchymal stromal cell (hMSC) can be guided by patterned and plain amorphous diamond (AD), titanium (Ti), tantalum (Ta) and chromium (Cr) coatings, produced on silicon wafer using physical vapour deposition and photolithography. At 7.5 h hMSCs density was 3.0–3.5× higher (P < 0.0003, except Ti) and cells were smaller (68 vs. 102 μm, P 0.000006–0.02) on patterns than on silicon background. HMSC-covered surface of the background silicon was lower on Ti than AD patterns (P = 0.015), but at 5 days this had reversed (P = 0.006). At 7.5 h focal vinculin adhesions and actin cytoskeleton were outgoing from pattern edges so cells assumed geometric square shapes. Patterns allowed induced osteogenesis, but less effectively than plain surfaces, except for AD, which could be used to avoid osseointegration. All these biomaterial patterns exert direct early, intermediate and late guidance on hMSCs and osteogenic differentiation, but indirect interactions exist with cells on silicon background.  相似文献   
27.
The flow control problem in multi-part failure prone manufacturing systems is considered. While computationnaly attractive, the near optimal controllers of Caramanis and Sharifnia, suffer from the drawback that the production capacity set must be approximated via a very restricted set of inscribed hypercubes, namely those for which a componentwise feasibility requirement is satisfied. Also, due to the completely decoupled nature of production along each component, utilization of the restricted capacity set is suboptimal. A class of capacity set incribed hypercube policies called simple maximal hedging (SMH) policies is introduced. In SMH policies production levels along the various components of the capacity set are coupled, the componentwise feasibility requirement is lifted, and there is no underutilization of production capacity if needed. In a p part types manufacturing system, for partwise additive cost functionals, it is shown that performance evaluation of a given SMH policy reduces to the analysis of p decoupled (fictitious) semi-Markovian machines. The machines are Markovianized via first passage-time analysis and a Padé approximants technique. Numerical optimization over the class of SMH policies in a sample manufacturing system indicates that their performance can come close to that of the optimal control.  相似文献   
28.
Flexibility can be defined as the ability to respond effectively to the ever‐changing and increasing needs of the customer. For this demand to be satisfied, flexibility should be built into the total chain of acquisition, processing, and distribution stages. As a result, there is an increasing interest in flexibility and flexibility enabling mechanisms/parameters to achieve the best strategy for obtaining the right and desired output. Although quite a number of flexibility definitions and mechanisms can be found in the literature, flexibility remains poorly understood and utilized in practice. That is due to the lack of standardization in the terminology about the flexibility definitions and mechanisms. This article presents the finding of an extensive literature survey to determine the Intra flexibility mechanisms/parameters. These mechanisms/parameters are then classified, according to their contribution to the supply chain stages and their interaction with Inter Flexibility mechanisms (e.g., Organizational structure flexibility, Technology flexibility, Information system flexibility, and Human resource flexibility). In addition, the crucial role of human factors and its relationship with flexibility mechanisms are investigated, and related flexibility mechanisms are identified. © 2002 John Wiley & Sons, Inc.  相似文献   
29.
In many user interfaces with restricted input capabilities, a time-out is used to automatically change the user interface (UI) from one mode to another. In this paper, we study the learning of time-outs and the effect of feedback on it in the case of mobile phone text entry. The effects of three different feedback schemes (auditory/visual/no feedback) on the learning of two different time-out lengths were compared. We measured the response time (RT) from the time-out occurrence to the time of the users action. Error rates and the development of the RTs in different schemes were used as measures of learning. We also studied if the users learned to estimate the time-out lengths, or if they just reacted to the available feedback. There were three main findings. Without feedback, RTs had a great variation. Auditory feedback enabled faster RTs than visual feedback. Finally, we found evidence of short-term learning, but not much of a lasting effect. The possible application of adapting time-out length to user RT is discussed.  相似文献   
30.
As economic and technological trends create spiraling demand for software resources, IS managers must increasingly weigh the risks of new technology against the costs of falling behind. in this environment, successful management of the IS organization depends less on the transfer of technological implements than on adopting the characteristics of a learning organization: a mature process, a culture supportive of continuous change, and effective management.  相似文献   
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