Design Approach for Calculating Deflection of FRP-Reinforced Concrete

Deflection of reinforced concrete is typically computed with an effective moment of inertia Ie that accounts for nonlinear behavior after the concrete cracks. Existing expressions for Ie tend to overpredict the member stiffness of concrete reinforced with fiber-reinforced polymer (FRP) bars, and an alternative expression is used as the basis for developing a practical design approach to compute deflection. The proposed expression has a rational basis that incorporates basic concepts of tension stiffening to provide a reasonable estimate of deflection for both steel and FRP-reinforced concrete without the need for empirically derived correction factors. Calculation of deflection with the proposed expression for Ie is recommended using the code value for the elastic modulus Ec of concrete because computed values of deflection are relatively insensitive to variations in Ec, and shrinkage restraint is taken into account by using a reduced cracking moment less than the code-based value of the cracking moment Mcr. Ie is conservatively based on the moment at the critical section (where the member stiffness is lowest), unless more accuracy is required with an integration-based expression that gives an equivalent moment of inertia Ie′ to account for the variation in stiffness along the member length. Recommendations are validated by comparison with a database of deflection test results for FRP-reinforced concrete.     

Ethnic-by-gender differences in cigarette smoking among Asian and Pacific Islanders.

We examined the interaction between ethnicity and gender in predicting the likelihood of having ever smoked (vs. having never smoked) and being a current smoker (vs. being a former smoker) and in predicting years spent as a regular smoker. These relationships were examined while controlling for the possible confounding effects of sociodemographics, psychosocial factors, and chronic medical conditions. The analysis examined cross-sectional data from 1,158 people of Native Hawaiian, Filipino, Japanese, and White ethnic ancestry, finding large ethnic and gender-ethnic differences in the prevalence of former and current smoking. Multiple regression analyses showed significant gender x ethnicity interactions in predicting the likelihood of having ever smoked but not in the likelihood of being a current smoker (vs. having quit) or in the duration of years spent smoking. The results of the present study have important implications for smoking prevention programs among men and women in three distinct Asian and Pacific Islander ethnic groups.     

Competing Fe (II)-induced mineralization pathways of ferrihydrite

Owing to its high surface area and intrinsic reactivity, ferrihydrite serves as a dominant sink for numerous metals and nutrients in surface environments and is a potentially important terminal electron acceptor for microbial respiration. Introduction of Fe (II), by reductive dissolution of Fe(III) minerals, for example, converts ferrihydrite to Fe phases varying in their retention and reducing capacity. While Fe(II) concentration is the master variable dictating secondary mineralization pathways of ferrihydrite, here we reveal thatthe kinetics of conversion and ultimate mineral assemblage are a function of competing mineralization pathways influenced by pH and stabilizing ligands. Reaction of Fe(II) with ferrihydrite results in the precipitation of goethite, lepidocrocite, and magnetite. The three phases vary in their precipitation extent, rate, and residence time, all of which are primarily a function of Fe(II) concentration and ligand type (Cl, SO4, CO3). While lepidocrocite and goethite precipitate over a large Fe(II) concentration range, magnetite accumulation is only observed at surface loadings greater than 1.0 mmol Fe(II)/g ferrihydrite (in the absence of bicarbonate). Precipitation of magnetite induces the dissolution of lepidocrocite (presence of Cl) or goethite (presence of SO4), allowing for Fe(III)-dependent crystal growth. The rate of magnetite precipitation is a function of the relative proportions of goethite to lepidocrocite; the lower solubility of the former Fe (hydr)oxide slows magnetite precipitation. A one unit pH deviation from 7, however, either impedes (pH 6) or enhances (pH 8) magnetite precipitation. In the absence of magnetite nucleation, lepidocrocite and goethite continue to precipitate at the expense of ferrihydrite with near complete conversion within hours, the relative proportions of the two hydroxides dependent upon the ligand present. Goethite also continues to precipitate at the expense of lepidocrocite in the absence of chloride. In fact, the rate and extent of both goethite and magnetite precipitation are influenced by conditions conducive to the production and stability of lepidocrocite. Thus, predicting the secondary mineralization of ferrihydrite, a process having sweeping influences on contaminant/nutrient dynamics, will need to take into consideration kinetic restraints and transient precursor phases (e.g., lepidocrocite) that influence ensuing reaction pathways.     

Adhesion of a Micro Double Cantilever Beam Driven by Capillary Forces

Capillary forces present during the manufacturing and operation of microelectromechanical structures have been shown to cause collapse of these structures. Once collapsed these structures may permanently adhere together. In this paper we study the adhesion of a microstructure represented by a double cantilever beam (DCB); such adhesion is driven by both the capillary forces from a liquid droplet located between the DCB and the adhesion forces between the solids. The DCB is modeled using both a beam theory that accounts for geometrical nonlinearity and the linearized beam theory. This model rigorously couples DCB deformation, capillary forces, meniscus movement and adhesion, and reveals four dimensionless parameters that govern the adhesion problem. How changes in these parameters influence the capillary forces, the length of the contact zone, and the contact force is discussed in detail.     

A tale of three greenway trails: user perceptions related to quality of life

Urban sprawl and renewed concern for the environment have helped create new policies and initiatives designed to enhance community quality of life. Among these are transportation enhancements mandated in ISTEA and TEA21. Funding through transportation enhancements has helped to spur the designation and development of greenway trails with the intent of fostering alternative transportation and generally making cities more livable. This paper presents research conducted on three greenway trails in Texas. The research was based on the human ecosystem concept and was intended to determine if and how such greenway facilities were contributing to quality of life and how people might perceive such contributions based on the way they used the trail (e.g. for transportation or recreation). Results indicated that most people used greenway trails for recreation but that trails differed in user types and activities based on location and policy. Users felt that these urban greenway trails were contributing most to community quality of life through resident health/fitness, the natural areas they provide, better land use and resident pride. They felt that they contributed least to diversifying industry, business development and access to shopping areas or public transportation. Those who used trails for transportation scored trails as contributing more toward reducing pollution, reducing transportation costs and providing better access to work than did those who used trails only for recreation. Implications for understanding use and users in the designation, design and development of urban greenway trails are discussed.     

Enzyme Directed Templating of Artificial Bone Mineral

Bone is one of Nature's most remarkable materials, not only for its mechanical properties but also for its ability to repair fractures and remodel its microstructure in response to stress. At the nanoscale bone is a supramolecular matrix of collagen fibers reinforced by hydroxyapatite crystals with a high degree of order. Emulating elements of the biological synthesis of this composite could help develop strategies for advanced materials. Previous work has demonstrated the use of functionalized peptide amphiphile nanofibers in a two-dimensional system to emulate hydroxyapatite mineralization in natural bone. We describe here an artificial, in vitro biomineralization process that allows a similar process to occur in three dimensions. The system employs the natural enzyme alkaline phosphatase and a phosphorylated, anionic nanofiber gel matrix to template hydroxyapatite nanocrystals with size, shape, and crystallographic orientation resembling natural bone mineral. The formation of this biomimetic mineral in three dimensions results from the synergy of fiber-induced nucleation and the temporal control of phosphate ion harvesting by the enzyme. Gradual enzymatic harvesting of ions for crystal growth and the strong nucleating ability of the phosphorylated fibers suppresses uncontrolled precipitation of mineral. The strategy could lead to biomimetic materials to promote bone regeneration or the synthesis of hybrid materials with crystallographically defined structures.     

Influences of iron, manganese, and dissolved organic carbon on the hypolimnetic cycling of amended mercury

The biogeochemical cycling of iron, manganese, sulfide, and dissolved organic carbon were investigated to provide information on the transport and removal processes that control the bioavailability of isotopic mercury amended to a lake. Lake profiles showed a similar trend of hypolimnetic enrichment of Fe, Mn, DOC, sulfide, and the lake spike ((202)Hg, purity 90.8%) and ambient of pools of total mercury (HgT) and methylmercury (MeHg). Hypolimnetic enrichment of Fe and Mn indicated that reductive mobilization occurred primarily at the sediment-water interface and that Fe and Mn oxides were abundant within the sediments prior to the onset of anoxia. A strong relationship (r(2)=0.986, n=15, p<0.001) between filterable Fe and Mn indicated that reduction of Fe and Mn hydrous oxides in the sediments is a common in-lake source of Fe(II) and Mn(II) to the hypolimnion and that a consistent Mn:Fe mass ratio of 0.05 exists in the lake. A strong linear relationship of both the filterable [Fe] (r(2)=0.966, n=15, p<0.001) and [Mn] (r(2)=0.964, n=15, p<0.001) to [DOC] indicated a close linkage of the cycles of Fe and Mn to DOC. Persistence of iron oxides in anoxic environments suggested that DOC was being co-precipitated with Fe oxide and released into solution by the reductive dissolution of the oxide. The relationship between ambient and lake spike HgT (r(2)=0.920, n=27, p<0.001) and MeHg (r(2)=0.967, n=23, p<0.001) indicated that similar biogeochemical processes control the temporal and spatial distribution in the water column. The larger fraction of MeHg in the lake spike compared to the ambient pool in the hypolimnion suggests that lake spike may be more available for methylation. A linear relationship of DOC to both filterable ambient HgT (r(2)=0.406, n=27, p<0.001) and lake spike HgT (r(2)=0.314, n=15, p=0.002) suggest a role of organic matter in Hg transport and cycling. However, a weak relationship between the ambient and lake spike pools of MeHg to DOC indicated that other processes have a major role in controlling the abundance and distribution of MeHg. Our results suggest that Fe and Mn play important roles in the transport and cycling of ambient and spike HgT and MeHg in the hypolimnion, in part through processes linked to the formation and dissolution of organic matter-containing Fe and Mn hydrous oxides particles.     

Cranial Base Synchondrosis Lacks PTHrP-Expressing Column-Forming Chondrocytes

The cranial base contains a special type of growth plate termed the synchondrosis, which functions as the growth center of the skull. The synchondrosis is composed of bidirectional opposite-facing layers of resting, proliferating, and hypertrophic chondrocytes, and lacks the secondary ossification center. In long bones, the resting zone of the epiphyseal growth plate houses a population of parathyroid hormone-related protein (PTHrP)-expressing chondrocytes that contribute to the formation of columnar chondrocytes. Whether PTHrP⁺ chondrocytes in the synchondrosis possess similar functions remains undefined. Using Pthrp-mCherry knock-in mice, we found that PTHrP⁺ chondrocytes predominantly occupied the lateral wedge-shaped area of the synchondrosis, unlike those in the femoral growth plate that reside in the resting zone within the epiphysis. In vivo cell-lineage analyses using a tamoxifen-inducible Pthrp-creER line revealed that PTHrP⁺ chondrocytes failed to establish columnar chondrocytes in the synchondrosis. Therefore, PTHrP⁺ chondrocytes in the synchondrosis do not possess column-forming capabilities, unlike those in the resting zone of the long bone growth plate. These findings support the importance of the secondary ossification center within the long bone epiphysis in establishing the stem cell niche for PTHrP⁺ chondrocytes, the absence of which may explain the lack of column-forming capabilities of PTHrP⁺ chondrocytes in the cranial base synchondrosis.     

Quinolizidines as Novel SARS-CoV-2 Entry Inhibitors

COVID-19, caused by the highly transmissible severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has rapidly spread and become a pandemic since its outbreak in 2019. We have previously discovered that aloperine is a new privileged scaffold that can be modified to become a specific antiviral compound with markedly improved potency against different viruses, such as the influenza virus. In this study, we have identified a collection of aloperine derivatives that can inhibit the entry of SARS-CoV-2 into host cells. Compound 5 is the most potent tested aloperine derivative that inhibited the entry of SARS-CoV-2 (D614G variant) spike protein-pseudotyped virus with an IC₅₀ of 0.5 µM. The compound was also active against several other SARS-CoV-2 variants including Delta and Omicron. Results of a confocal microscopy study suggest that compound 5 inhibited the viral entry before fusion to the cell or endosomal membrane. The results are consistent with the notion that aloperine is a privileged scaffold that can be used to develop potent anti-SARS-CoV-2 entry inhibitors.     

Formation and emission of hydrogen chloride in indoor air

To improve our understanding of chlorine chemistry indoors, reactive chlorine species such as hydrogen chloride (HCl) must be analyzed using fast time‐response measurement techniques. Although well studied outdoors, sources of HCl indoors are unknown. In this study, mixing ratios of gaseous HCl were measured at 0.5 Hz in the indoor environment using a cavity ring‐down spectroscopy (CRDS) instrument. The CRDS measurement rate provides a major advance in observational capability compared to other established techniques. Measurements of HCl were performed during three types of household activities: (a) floor exposure to bleach, (b) chlorinated and nonchlorinated detergent use in household dishwashers, and (c) cooking events. Surface application of bleach resulted in a reproducible increase of 0.1 ppbv in the affected room. Emissions of HCl from automated dishwashers were observed only when chlorinated detergents were used, with additional HCl emitted during the drying cycle. Increased mixing ratios of HCl were also observed during meal preparation on an electric element stovetop. These observations of HCl derived from household activities indicate either direct emission or secondary production of HCl via chlorine atoms is possible. Calculations of photolysis rate constants of chlorine atom precursors provide evidence that photolysis may contribute to indoor HCl levels.