Differences in detection of alcohol use in a prenatal population (on a Northern Plains Indian Reservation) using various methods of ascertainment

Although Fetal Alcohol Syndrome (FAS) rates have been reported to be higher in American Indian populations, no screening tool has been validated for alcohol use in American Indian women. The objectives of this study were to compare the detection of prenatal alcohol use by a self-administered questionnaire to detection by clinical interview; and to ascertain whether the screening tool would increase detection of pregnant women who are abusing alcohol. The hospital records of the women were reviewed for any history of alcohol-related illnesses or injuries to compare with results obtained from the questionnaire. Seventy women attending their first prenatal clinic visit on a reservation were screened for alcohol use. There was a wide range in detection of prenatal alcohol use (20%-71% of the sample detected) depending on the method used. There was a large variation in sensitivities (7%-93%) of the individual questions in identifying patients detected as "high risk" by the clinicians. The T-ACE screening questions significantly increased detection of alcohol use compared to detection by the clinicians (p = 0.04 Fisher's exact test). Due to the large variation between different methods of detection, it is recommended that screening tools that increase detection of alcohol use should be combined with methods of higher specificity such as using questions about quantity and frequency of alcohol intake, medical chart review and clinical interview. We also found that various interpretations of the screening questions by the patients highlighted the need to tailor the wording of individual questions to the particular patient population.     

Efficient resource allocation for genetic algorithm based multi-objective optimization with 1,000 simulations

This study pertains to practical use of the GA for industrial applications where only a limited number of simulations can be afforded. Specifically, an attempt is made to find an efficient allocation of the total simulation budget (population size and number of generations) for constrained multi-objective optimization. A study is conducted to seek improvements while restricting the number of simulations to 1,000. Parallelization is exploited using concurrent simulations for each GA generation on a HP quad-core cluster, and resulted in a significant time savings. Furthermore, the efficient distribution of computational effort to achieve the greatest improvement in performance was explored. Two analytical examples as well as an automotive crashworthiness simulation of a finite element model with 58,000 elements were used as test examples. Various population sizes and numbers of generations were tried while limiting the total number of simulations to 1,000. The optimization performance was compared with Monte-Carlo and space filling sampling methods. It was observed that using the GA, many feasible and trade-off solutions could be found. It is shown that allowing a large number of generations is beneficial to get good trade-off solutions. For the vehicle design, significant improvements in the performance were observed. This example also suggests that, for problems with a small feasible region, the number of feasible solutions can be significantly increased in the first few generations involving about 200 simulations.     

A low cost approach for the fabrication of microwave phase shifter on laminates

This paper presents a simple and low cost fabrication approach using extended printed circuit board processing techniques for an electrostatically actuated phase shifter on a common microwave laminate. This approach uses 15 μm thin copper foils for realizing the bridge structures as well as for a spacer. A polymeric thin film deposited by spin coating and patterned using lithographic process is used as a dielectric layer to improve the reliability of the device. The prototype of the phase shifter for X-band operation is fabricated and tested for electrical and electromechanical performance parameters. The realized devices have a figure of merit of 70°/dB for a maximum applied bias potential of 85 V. Since these phase shifters can be conveniently fabricated directly on microwave substrates used for feed distribution networks of phased arrays, the overall addition in cost, dimensions and processing for including these phase shifters in these arrays is minimal.

     

Application of support vector machines in scour prediction on grade-control structures

Research into the problem of predicting the maximum depth of scour on grade-control structures like sluice gates, weirs and check dams, etc., has been mainly of an experimental nature and several investigators have proposed a number of empirical relations for a particular situation. These traditional scour prediction equations, although offer some guidance on the likely magnitude of maximum scour depth, yet applicable to a limited range of the situations. It appears from the literature review that a regression mathematical model for predicting maximum depth of scour under all circumstances is not currently available. This paper explores the potential of support vector machines in modeling the scour from the available laboratory and field data obtained form the earlier published studies. To compare the results, a recently proposed empirical relation and a feed forward back propagation neural network model are also used in the present study. The outcome from the support vector machines-based modeling approach suggests a better performance in comparison to both the empirical relation and back propagation neural network approach with the laboratory data. The results also suggest an encouraging performance by the support vector machines learning technique in comparison to both empirical relation as well as neural network approach in scaling up the results from laboratory to field conditions for the purpose of scour prediction.     

Empirical data modeling in software engineering using radial basisfunctions

Many empirical studies in software engineering involve relationships between various process and product characteristics derived via linear regression analysis. We propose an alternative modeling approach using radial basis functions (RBFs) which provide a flexible way to generalize linear regression function. Further, RBF models possess strong mathematical properties of universal and best approximation. We present an objective modeling methodology for determining model parameters using our recent SG algorithm, followed by a model selection procedure based on generalization ability. Finally, we describe a detailed RBF modeling study for software effort estimation using a well-known NASA dataset     

The confounding effect of class size on the validity ofobject-oriented metrics

Much effort has been devoted to the development and empirical validation of object-oriented metrics. The empirical validations performed thus far would suggest that a core set of validated metrics is close to being identified. However, none of these studies allow for the potentially confounding effect of class size. We demonstrate a strong size confounding effect and question the results of previous object-oriented metrics validation studies. We first investigated whether there is a confounding effect of class size in validation studies of object-oriented metrics and show that, based on previous work, there is reason to believe that such an effect exists. We then describe a detailed empirical methodology for identifying those effects. Finally, we perform a study on a large C++ telecommunications framework to examine if size is really a confounder. This study considered the Chidamber and Kemerer metrics and a subset of the Lorenz and Kidd metrics. The dependent variable was the incidence of a fault attributable to a field failure (fault-proneness of a class). Our findings indicate that, before controlling for size, the results are very similar to previous studies. The metrics that are expected to be validated are indeed associated with fault-proneness     

Sodium metabisulfite and SO2 release: an under-recognized hazard among shrimp fishermen

Since the introduction of sodium metabisulfite as a food preservative, it has been associated with several idiosyncratic reactions (eg, bronchospasm, oculonasal symptoms, and urticaria/angioedema) in sulfite-sensitive individuals. The pathogenic mechanism of these reactions is not yet understood. We report the case of two crewmen on a shrimp trawler who were found dead in the ship's hold. Their deaths had occurred while they were applying dry sodium metabisulfite, referred to as "shrimp dip" in the shrimping industry. Postmortem examinations showed diffuse pulmonary edema consistent with death secondary to asphyxia. Associated findings were visceral congestion. Although it is possible to measure death from sodium metabisulfite with available records, its potential morbidity cannot be estimated. It is known that sodium metabisulfite can react with acids and water, releasing toxic sulfur dioxide (SO2) gas. In addition, SO2 gas reacts with respiratory tissue forming sulfureous acid, and inducing a pulmonary reaction causing hypoxemia. Furthermore, sodium metabisulfite, compared with sodium bisulfite, has a much greater propensity to release SO2 gas. We conclude that there is a need for improved education regarding the potential side effects of sodium metabisulfite, thus eliminating needless occupational morbidity and mortality.     

Investigating Role of Growing Adsorbent Bed in a Dead-End PAC/UF Process

A two-stage mathematical model was developed to describe adsorbate removal in a dead-end powdered activated carbon/ultrafiltration (PAC/UF) membrane process. Para-nitrophenol (PNP) was used as the model organic compound. The first stage accounted for adsorbate removal during transport from the initial PAC contact with the PNP solution to the membrane system, and the second stage accounted for additional PNP removal due to the retention of the PAC in a growing bed on the membrane surface. The PAC adsorptive capacity was described using the Langmuir isotherm, whose parameters were estimated from isotherm experiments. Transport of the PNP through the PAC particle was described using the homogeneous surface diffusion model and the surface diffusivity was estimated from batch experiments. The two stage model predicted the effluent concentrations from the PAC/UF process during the early stages of the experiments, but model improvements are required to more accurately predict the latter stages. A batch model can be used to describe the effluent PNP concentration from the PAC/UF process if dispersion is neglected.