Laryngeal survey in glyphosate intoxication: a pathophysiological investigation

Respiratory aspiration is a serious potential complication of glyphosate-surfactant herbicide intoxication. From October 1, 1992 to June 30, 1996, we performed laryngeal evaluations in 53 cases to investigate the possible pathophysiological mechanism of glyphosate intoxication. There were 36 cases with significant laryngeal injury. The blood WBC count were significantly higher and the hospital stays were significantly longer in patients with laryngeal injury, when compared with patients with no laryngeal injury (Student t-test, P < 0.005). Laryngeal injury was strongly correlated with aspiration pneumonitis (mean 2 = 4.449, P < 0.05). We concluded that laryngeal injury may be the major cause of aspiration that leads to some degree of morbidity and mortality, following concentrated glyphosate-surfactant herbicide intoxication. Laryngeal survey may be indicated in cases of glyphosate-surfactant intoxication, to evaluate the severity of mucosal injury, and to apply adequate supportive management as early as possible to prevent from aspiration complications and even mortality.     

Simulcast packet transmission in ad hoc networks

In previous work, unequal error-protection techniques have been applied to improve the throughput of a wireless communication system in which a transmission is received by several radios with different capabilities. For instance, these capabilities may correspond to differences in path loss, fading, or interference. By taking advantage of the broadcast nature of the channel, additional messages for the more-capable receivers can be included on transmissions to the less-capable receivers at very little cost (in terms of required energy at the transmitter or error probabilities at the receivers). This technique has been termed simulcasting or multicast signaling. In this paper, we consider the use of these techniques in an ad hoc network. These techniques impact the link throughput, end-to-end throughput, and network connectivity. We investigate how the choice of parameters for the simulcasting technique affects these network performance metrics. The results indicate that a properly chosen simulcasting technique can improve the link and end-to-end throughput in wireless ad hoc networks with only a slight degradation in other metrics, such as network connectivity.     

Concurrent primary carcinoma of the gallbladder and acute cholecystitis

BACKGROUND/AIMS: Primary carcinoma of the gallbladder is rare and associated with a late diagnosis and poor prognosis. Concurrent acute cholecystitis frequently obscures the presence of carcinoma. The information regarding gallbladder carcinoma with acute cholecystitis is limited. In order to better understand the presentation of gallbladder carcinoma with acute cholecystitis, we retrospectively reviewed the data of patients with primary carcinoma of the gallbladder. METHODOLOGY: The data of 86 patients with primary carcinoma of the gallbladder treated between 1979 and 1994 were compiled and reviewed. The patients were divided into 2 groups: Group 1 (with acute cholecystitis, 21 patients) and Group 2 (without cholecystitis, 65 patients). Clinicopathological comparisons were made and evaluated between these two groups RESULTS: The average age of Group 1 patients was older than that of Group 2 patients (75+/-2 years vs. 63+/-2 years; p<0.05). Three Group 1 patients presented with sepsis. The interval between the onset of symptoms and hospital admission in Group 2 patients was significantly (p<0.05) longer than that in Group 1 patients (243+/-95 days vs. 20+/-11 days). Leukocytosis (>11,000/mm3) was more common in Group 1 patients than in Group 2 patients (47.6% vs. 15.4%). Jaundice was more common in Group 2, and fever was common in Group 1. The majority of Group 2 gallbladder cancers were stage V (75.4%). In contrast, 52.4% of Group 1 gallbladder cancers were stage III and 38.1% were stage V. The 30-day postoperative mortality rate in Group 1 and Group 2 patients was 9.5% and 7.7%, respectively. The cumulative survival of Group 1 patients was not different from that of Group 2 patients (log-rank test, p>0.05). CONCLUSIONS: Age, the interval of symptoms prior to admission, the location of abdominal pain, fever, leukocytosis, and the absence of jaundice suggested the presence of acute cholecystitis in gallbladder carcinoma. A high index of suspicion of the disease, intraoperative examination of gallbladder specimens, and more aggressive surgical treatment may improve patient survival.     

Priming and aging: an electrophysiological investigation of N400 and recall

Twenty young (20.5 years) and 20 middle-aged academics (57.2 years) performed a priming-recall task which was presented in three blocks. In each block, participants read 40 word pairs after which a recall task had to be carried out. Half of the word pairs were highly associated while the others were low associated. Targets showed the N400 of the middle-aged group to be both delayed and smaller in amplitude for low-associated items. N400 of primes, however, showed no age-related latency difference but was smaller for the middle-aged group due to a positive shift. It is argued that this shift possibly indicates age differences in semantic activation or buildup of context. A reanalysis showed individual differences in word pair processing to depend on recall performance. In general, high recallers were found to show a much larger differentiation between low- and high-associated targets. This resulted from a much larger N400 component elicited by low-associated targets and a more positive ERP in the N400-region for the high-associated targets. It is suggested that the middle-aged subjects activated the expected target word to a level at least equivalent to the younger subjects, but that the activated network itself was larger/less selective particularly in subjects showing a low recall.     

Adaptation effects and reversible figures: a comment on Horlitz and O'Leary

Horlitz and O'Leary have provided further evidence for the important role of such top-down processes as attention and familiarity on reported reversals of ambiguous figures. As such, these results are consistent with the claims of several other investigators who have argued that any theory of phenomenal reversal that is based solely on passive neural processes is likely to be incomplete. However, Horlitz and O'Leary make the additional claims (1) that the several reports of adaptation effects in the literature are readily reinterpreted within an information-access framework and (2) that their own empirical work demonstrates a basic failure of neural-adaptation effects with reversible figures. It is proposed here that these claims must be viewed with caution. First, Horlitz and O'Leary's explanation for the discrepancy of their results from those of ostensibly similar experimental procedures in the reversible-figure literature is not the only, or the most likely, possibility. A plausible alternative model that posits critical procedural differences (specifically, duration of adaptation) across studies has been offered, and supporting empirical work for this latter suggestion has been presented. Second, the empirical efforts of Horlitz and O'Leary, while providing further evidence for top-down processes, do not eliminate the likely role of adaptation effects with reversible figures. There is strong reason to believe that the viewing conditions selected by these researchers may not have been sufficient to produce appreciable adaptation. Moreover, there is excellent reason to believe that both bottom-up and top-down processes moderate reported reversals of these figures.(ABSTRACT TRUNCATED AT 250 WORDS)     

The presence of cytoplasmic lipid droplets is not sufficient to account for neutral lipid signals in the 1H MR spectra of neutrophils

Stimulation of human peripheral blood neutrophils with lipopolysaccharide (LPS), arachidonic acid (AA) and oleic acid (OA) resulted in significant increases in cytoplasmic lipid droplets. This phenomenon was also observed in enucleated and degranulated cytoplasts prepared from neutrophils stimulated with LPS. In contrast, only LPS and high concentrations of OA (10 microM) produced an increase in the lipid intensities of the MR spectra of neutrophils as determined by COSY cross peak volume measurements. Lipid intensities in cells stimulated with OA (2.5 microM) and AA (2.5 microM) and phorbol myristate acetate (20 nM) were not elevated. LPS stimulation of resting cytoplasts resulted in increased lipid droplets but not MR lipid intensities. These data suggest that while cytoplasmic lipid droplets may correlate with MR lipid intensity under some circumstances, their presence is not sufficient to account for increased neutral lipid signals.