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31.
Xiao-Ying Wang Jonathan M. Garibaldi Benjamin Bird Michael W. George 《Applied Intelligence》2007,27(3):237-248
Recently Fourier Transform Infrared (FTIR) spectroscopic imaging has been used as a tool to detect the changes in cellular
composition that may reflect the onset of a disease. This approach has been investigated as a mean of monitoring the change
of the biochemical composition of cells and providing a diagnostic tool for various human cancers and other diseases. The
discrimination between different types of tissue based upon spectroscopic data is often achieved using various multivariate
clustering techniques. However, the number of clusters is a common unknown feature for the clustering methods, such as hierarchical
cluster analysis, k-means and fuzzy c-means. In this study, we apply a FCM based clustering algorithm to obtain the best number
of clusters as given by the minimum validity index value. This often results in an excessive number of clusters being created
due to the complexity of this biochemical system. A novel method to automatically merge clusters was developed to try to address
this problem. Three lymph node tissue sections were examined to evaluate our new method. These results showed that this approach
can merge the clusters which have similar biochemistry. Consequently, the overall algorithm automatically identifies clusters
that accurately match the main tissue types that are independently determined by the clinician. 相似文献
32.
33.
Cocaine lowers brain reward thresholds, reflecting increased brain reward function. The authors investigated whether, similar to acute cocaine administration, cocaine-predictive conditioned stimuli would lower intracranial self-stimulation (ICSS) thresholds. Rats received a saline injection for 5 days, a cocaine injection (10 mg/kg) for 20 consecutive days, then saline for 5 additional days. Thresholds were measured immediately before and 10 min after each injection. The initial 5 saline injections had no effect on thresholds, whereas cocaine significantly lowered thresholds for 20 days. There was no tolerance or sensitization to this effect of cocaine over days. During the last 5 days when cocaine administration was substituted with saline, rats demonstrated a conditioned lowering of thresholds during the 2nd daily ICSS session. These data demonstrate that cocaine-predictive conditioned stimuli induce a conditioned facilitation of brain reward function. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
34.
This two-part paper presents a closed-form procedure for evaluation of estimates of local thermomechanical stress fields in two-phase fibrous composites and laminates. The first part is concerned with a unidirectional elastic laminate subjected to uniform mechanical loads and to uniform changes in temperature. Both phases are assumed to be elastic, with temperature-dependent moduli and expansion coefficients; the solution reflects the influence of thermomechanical interactions. Exact solutions are not possible for any real system, because the local geometry is not known in detail. Instead, estimates of the fields are found from a modified Mori-Tanaka approximation. Examples are presented for two SiC/Ti---Al---Nb composites. Local stresses of interest are found after cooling from fabrication to room temperature. The presence of local yielding, and the influence of coupling terms on the local stress magnitudes are examined. Extension of the results to laminated plates is presented in Part II (Dvorak, G.J., Chen, T. & Teply, J., Composites Science and Technology, 43 (1992) 359–368, this issue). 相似文献
35.
Experiments were conducted to investigate the fate of ethylbenzoate and soil microorganisms in shallow aquifers. Biodegradation and volatilization have been identified as the major mechanisms in attenuating ethylbenzoate in contaminated soils. The rate of volatilization was experimentally found to be limited by gas-phase diffusion. The parameters of an available model, i.e., the maximum specific growth rate and the saturation constant, have been estimated by fitting the model to the experimental data obtained with ethylbenzoate as the carbon source; the former was 0.49 h−1, and the latter was 62 mg L−1. Various facets of biodegradation, including the effects of mass-transfer resistance and initial distribution of microorganisms, have been numerically analyzed on the basis of the model. 相似文献
36.
37.
WJ Enright DJ Prendiville LJ Spicer PR Stricker AP Moloney TF Mowles RM Campbell 《Canadian Metallurgical Quarterly》1993,71(9):2395-2405
The objective of this study was to determine the effect of long-term administration of a growth hormone (GH)-releasing factor analog (GRFa) and(or) thyrotropin-releasing hormone (TRH) on growth, feed efficiency, carcass characteristics, and blood hormones and metabolites in beef heifers. Crossbred heifers (n = 48; 345.9 +/- 2.8 kg) were divided into four equal groups: control (vehicle), 1 microgram of GRFa (human GRF 1-29 analog).kg BW-1.d-1, 1 microgram of TRH.kg BW-1.d-1, or GRFa + TRH. Daily s.c. injections continued for 86 d. Blood samples were collected from half of the heifers after injection on d 1, 36, and 78. On d 89, all heifers were slaughtered. Treatments did not affect (P > .05) ADG but GRFa + TRH decreased (P < .05) ADFI relative to all other treatments. Feed conversion efficiency tended (P < .10) to be improved in the groups given GRFa alone or TRH alone. Treatment with GRFa and(or) TRH did not affect carcass weight, dressing percentage, conformation score, backfat thickness, or weights of liver, kidneys, pituitary, and ovaries. The GRFa + TRH treatment reduced (P < .05) fat score and increased (P < .05) longissimus muscle area relative to other treatments. The GRFa treatments reduced (P < .05) the weight and fat percentage of the mammary gland and increased (P < .05) heart weight. Treatment with TRH alone failed to stimulate GH on d 1, 36, and 78. Treatment with GRFa alone increased (P < .05) GH above controls on d 36, whereas GRFa + TRH increased (P < .05) GH on d 1, 36, and 78. Treatment with GRFa alone increased (P < .05) IGF-I only on d 1, whereas GRFa + TRH was without effect on all days. Across sampling days, treatments had little effect on blood concentrations of insulin, triiodothyronine, nonesterified fatty acids, urea nitrogen, and glucose. The GRFa alone and GRFa + TRH decreased (P < .05) and TRH alone increased (P < .05) thyroxine concentrations. In conclusion, with the dose and administration regimen used, GRFa and(or) TRH yielded small but positive improvements in animal performance. 相似文献
38.
Analysis of characteristic odors from human male axillae 总被引:7,自引:0,他引:7
Xiao -nong Zeng James J. Leyden Henry J. Lawley Kiyohito Sawano Isao Nohara George Preti 《Journal of chemical ecology》1991,17(7):1469-1492
A number of studies concerning the analysis of axillary odors have assumed that the characteristic odor produced in the axillae is due to volatile steroids and isovaleric acid. Organoleptic evaluation of Chromatographic eluants from axillary extracts was employed to isolate the region in the chromatogram where the characteristic odor eluted. The odor of the dissolved eluant was eliminated when it was treated with base, suggesting that acids make up the characteristic axillary odor. Subsequent extraction of the pH-adjusted axillary extract in conjunction with organoleptic evaluation of the Chromatographic eluant, preparative gas chromatography, and analysis by GC-MS as well as GC-FTIR showed the presence of a number of C6 to C11 straight-chain, branched, and unsaturated acids as important contributors to the axillary odor. The major odor component is (E)-3-methyl-2-hexenoic acid. Three homologous series of minor components are also important odor contributors; these consist of the terminally unsaturated acids, the 2-methyl-C6 to -C10 acids and the 4-ethyl-C5 to -C11 acids. These types of acids have not been reported previously as components of the human axillary secretions and have not been proposed previously as part of the principal odor components in this area. 相似文献
39.
George Wachira 《突发事故与危机管理杂志》1997,5(2):109-117
This paper reflects on African conflicts as compound disasters. A compound disaster is defined as an emergency situation with adverse consequences resulting from different, but related, disaster-agents (ICLA, 1996). In a natural disaster situation, for instance, an earthquake that is quickly followed by a fire outbreak, gas leakage, the disruption of water supply and the outbreak of water-borne diseases, would be regarded as a compound disaster. Similarly, armed conflicts trigger a chain of consequences. The focus of this paper is the complexity of the consequences and impact of conflicts in Africa. To a lesser extent, the paper looks at the complex causes of the conflicts themselves and, finally, examines challenges with regard to responses. 相似文献
40.
M Fortuin N Maine M Mendy A Hall M George H Whittle 《Canadian Metallurgical Quarterly》1995,89(3):326-329
A nation-wide cross-sectional survey of 816 children 3-4 years old was carried out in The Gambia between September 1990 and July 1991 to assess the seroprevalence of antibodies against 3 diseases included in the expanded programme on immunization: measles, poliomyelitis and tetanus. Among 689 children whose records were available, 94.5% were fully immunized. Measles vaccine was administered to 97% of the children and 91% of these had detectable antibodies at the time of the survey. Antibodies against type 1 and type 3 polioviruses, after up to 6 doses of oral polio vaccine, were present in 88.1% and 89.3% of the children respectively. Ninety-seven percent of the children who had received 4 doses of diphtheria-pertussis-tetanus vaccine (DPT) and 91% of those who received 3 doses had detectable tetanus toxoid antibodies at the age of 3-4 years. This study shows that serological responses to EPI vaccines given in infancy persist at very satisfactory levels throughout early childhood. 相似文献