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101.
102.
103.
BT Teh S Kyt?l? F Farnebo L Bergman FK Wong G Weber N Hayward C Larsson B Skogseid A Beckers C Phelan M Edwards M Epstein F Alford D Hurley S Grimmond G Silins M Walters C Stewart J Cardinal S Khodaei F Parente L Tranebjaerg R Jorde P Salmela 《Canadian Metallurgical Quarterly》1998,83(8):2621-2626
Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant disease characterized by neoplasia of the parathyroid glands, the endocrine pancreas, and the anterior pituitary gland. In addition, families with isolated endocrine neoplasia, notably familial isolated hyperparathyroidism (FIHP) and familial acromegaly, have also been reported. However, whether these families constitute MEN 1 variants or separate entities remains speculative as the genetic bases for these diseases are unclear. The gene for MEN 1 has recently been cloned and characterized. Using single strand conformation analysis (SSCA) and sequencing, we performed mutation analysis in: a) a total of 55 MEN 1 families from 7 countries, b) 13 isolated MEN 1 cases without family history of the disease, c) 8 acromegaly families, and d) 4 FIHP families. Mutations were identified in 27 MEN 1 families and 9 isolated cases. The 22 different mutations spread across most of the 9 translated exons and included frameshift (11), nonsense (6), splice (2), missense mutations (2), and in-frame deletions (1). Among the 19 Finnish MEN 1 probands, a 1466del12 mutation was identified in 6 families with identical 11q13 haplotypes and in 2 isolated cases indicating a common founder. One frameshift mutation caused by 359del4 (GTCT) was found in 1 isolated case and 4 kindreds of different origin and haplotypes; this mutation therefore represents a common "warm" spot in the MEN1 gene. By analyzing the DNA of the parents of an isolated case one mutation was confirmed to be de novo. No mutation was found in any of the acromegaly and small FIHP families, suggesting that genetic defects other than the MEN1 gene might be involved and that additional such families need to be analyzed. 相似文献
104.
Servin Anna; Nordenstr?m Anna; Larsson Agne; Bohlin Gunilla 《Canadian Metallurgical Quarterly》2003,39(3):440
Gender-typed behaviors and interests were investigated in 26 girls, aged 2-10 years, affected with congenital adrenal hyperplasia (CAH) and in 26 unaffected girls matched for age. Girls with CAH were more interested in masculine toys and less interested in feminine toys and were more likely to report having male playmates and to wish for masculine careers. Parents of girls with CAH rated their daughters' behaviors as more boylike than did parents of unaffected girls. A relation was found between disease severity and behavior indicating that more severely affected CAH girls were more interested in masculine toys and careers. No parental influence could be demonstrated on play behavior, nor did the comparison of parents' ratings of wished for behavior versus perceived behavior in their daughters indicate an effect of parental expectations. The results are interpreted as supporting a biological contribution to differences in play behavior between girls with and without CAH. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
105.
Two‐scale finite element modelling of reinforced concrete structures: Effective response and subscale fracture development 下载免费PDF全文
A. Sciegaj F. Larsson K. Lundgren F. Nilenius K. Runesson 《International journal for numerical methods in engineering》2018,114(10):1074-1102
A two‐scale model is derived from a fully resolved model where the response of concrete, steel reinforcement, and bond between them are considered. The pertinent “effective” large‐scale problem is derived from selective homogenisation in terms of the equilibrium of reinforced concrete considered as a single‐phase solid. Variational formulations of the representative volume element problem are established in terms of the subscale displacement fields for the plain concrete continuum and the reinforcement bars. Dirichlet and Neumann boundary conditions (BCs) are imposed on the concrete (pertaining to uniform boundary displacement and constant boundary traction, respectively) and on the reinforcement bars (pertaining to prescribed boundary displacement and vanishing sectional forces, respectively). Different representative volume element sizes and combinations of BCs were used in FE2 analyses of a deep beam subjected to four‐point bending. Results were compared with those of full resolution (single‐scale). The most reliable response was obtained for the case of Dirichlet‐Dirichlet BCs, with a good match between the models in terms of the deformed shape, force‐deflection relation, and average strain. Even though the maximum crack widths were underestimated, the Dirichlet‐Dirichlet combination provided an approximate upper bound on the structural stiffness. 相似文献
106.
Synthesis of branched 'nanotrees' by controlled seeding of multiple branching events 总被引:2,自引:0,他引:2
Dick KA Deppert K Larsson MW Mårtensson T Seifert W Wallenberg LR Samuelson L 《Nature materials》2004,3(6):380-384
The formation of nanostructures with controlled size and morphology has been the focus of intensive research in recent years. Such nanostructures are important in the development of nanoscale devices and in the exploitation of the properties of nanomaterials. Here we show how tree-like nanostructures ('nanotrees') can be formed in a highly controlled way. The process involves the self-assembled growth of semiconductor nanowires via the vapour-liquid-solid growth mode. This bottom-up method uses initial seeding by catalytic nanoparticles to form the trunk, followed by the sequential seeding of branching structures. Each level of branching is controlled in terms of branch length, diameter and number, as well as chemical composition. We show, by high-resolution transmission electron microscopy, that the branching mechanism gives continuous crystalline (monolithic) structures throughout the extended and complex tree-like structures. The controlled seeding method that we report here has potential as a generic means of forming complex branching structures, and may also offer opportunities for applications, such as the mimicking of photosynthesis in nanotrees. 相似文献
107.
Reactive sputtering may be accomplished by mixing the inert gas argon with some reactive gas during sputtering. To form ZrN, sputtered zirconium atoms must react with nitrogen. At a specific deposition rate, a certain number FN0 of nitrogen atoms must arrive at the substrate. This requirement is fulfilled at the partial pressure PN = PN0. The minimum partial pressure PN0 to obtain a nitride is often detected by a sharp decrease in sputtering rate at a specific N2 partial pressure. However, during reactive sputtering of for example ZrN we found that the value of PN0 was strongly dependent on the total gas throughout in the vacuum system. An increase in total gas throughput causes a decrease in the value of PN0.
The decrease in sputtering rate has indirectly been measured by optical emission spectroscopy from the sputtering plasma. 相似文献
108.
The non-linear thermo-metallurgical problem, relevant for the cooling of a molten metal including the macro-segregation that
occurs during the cooling process, is studied here. Due to the strong non-linearities involved in phase transformations, it
is necessary to use a fine resolution in space-time in a finite element approximation in order to meet accuracy requirements.
We derive space-time FE-methods based on the discontinuous and continuous Galerkin method in time for the energy equation.
This formulation integrates the stored energy exactly for a given heat flux. When macro-segregation is incorporated into the
model, the problem can be formulated in such a way that the phase-transition drives a flow of species. In addition, diffusion
is possible throughout the domain. The model can be further rewritten using a potential approach. By this approach for modelling
macro-segregation, we are able to obtain discretizations that guarantee that the balance equations are satisfied, and it is
possible to solve the phase-transition problem either as a field problem or as a local problem (defined by a local evolution
rule). 相似文献
109.
针对多角度偏振成像仪(Directional Polarimetric Camera,DPC)数据,提出了基于多角度多光谱偏振信息的气溶胶光学厚度反演方法。该方法使用Nadal-Breon半经验模型计算地表偏振反射率,以扣除地表影响;采用倍加累加法矢量辐射传输模型构建气溶胶参数查找表,通过计算最小残差,动态确定最优气溶胶模型,从而实现陆地上空气溶胶光学厚度的反演。使用DPC的L1级条带数据,反演获得了中国东部地区气溶胶光学厚度的空间分布,并与MODIS产品和AERONET地基站点数据分别进行了对比,反演结果与MODIS气溶胶产品的整体分布具有很好的一致性;同时,与AERONET地基站点观测结果具有较高的相关性,670 nm和865 nm两个波段的相关系数都在0.8以上,说明该算法模型反演陆地上空的气溶胶光学厚度准确可靠,可为DPC遥感大气气溶胶提供技术支持。 相似文献
110.
ɛ ′) and relative loss factor (ɛ′′) give information on how the microwaves can penetrate into the wood object and of possible thermal gradient effects on
the wood during modification. This investigation shows that microwave energy effectively heats the acetic anhydride used for
modification by acetylation and that the power penetration depth (d
p) of the microwaves is about 10 cm in acetic anhydride impregnated wood. The relative permittivity and the relative loss factor
were found to decrease with increasing temperature, which indicates that the energy absorption will preferably be directed
to less heated parts of the wood object. This will promote a more uniform heat distribution, and, accordingly, a more uniform
acetylation of the wood.
d p) für das getr?nkte Holz etwa 10 cm betr?gt. Dielektrizit?tskonstante und Verlustfaktor nehmen mit steigender Temperatur ab; d.h. die Energieaufnahme wird vorzugsweise zu den weniger erhitzten Teilen des Holzes gelenkt. Das wiederum f?rdert eine gleichf?rmige Acetylierung des Holzes.相似文献