压水堆核电站主管道材料的低周疲劳行为研究

对压水堆核电站主管道材料Z3CN20.09M进行室温与350℃低周疲劳性能试验,得到材料循环变形规律和寿命演化模型.结果表明,主管道材料表现为先强化后软化的循环特性,但强化的程度取决于温度和应变幅;当应变幅较大时,高温疲劳断裂寿命高于室温疲劳断裂寿命,但随着应变幅的降低,二者的疲劳断裂寿命差别逐渐减小.常温与350℃高...     

考虑纵向加速度的三自由度车辆单轨非线性模型的建立与分析

线性二自由度车辆单轨模型是最早和最经典的车辆模型,也是车辆系统动力学的基础。本文在此基础上提出了考虑汽车质心纵向速度、侧向速度和横摆角速度的三自由度车辆单轨非线性模型,建模时充分考虑了侧偏角和侧向力的非线性特性。通过Matlab/Simulink仿真结果,验证了三自由度模型的准确性;并通过对纵向初速度和驱动力矩的影响分析,说明了三自由度车辆单轨模型具有更高的适用性。     

木城涧矿煤层高压注水的数值模拟分析

为解决京煤公司木城涧矿冲击地压灾害问题，在煤巷掘进时实施预先煤层注水。为研究煤体的渗透特征，在该矿北8槽煤掘进工作面进行了现场单孔等压注水试验，测定了钻孔两侧煤体的湿润水分增值。依据该试验数据用可变容差最优化搜索方法对模型参数进行反演，得到煤体的导水和贮水特征参数，表明该北8槽煤属低湿润饱和煤层，导水性差，适合用高压注水。用数值模拟方法详细描述了在7．0MPa压力下的煤层注水动态过程，通过模拟计算，给出了注水压力-时间-湿润范围三者的动态变化关系。分析了在不同注水压力下的湿润分布的特点，指出合理湿润效果的注水压力在10．0MPa以上。     

核电站抗震支撑螺栓应力腐蚀开裂倾向研究与预防措施

初步分析了核电站抗震支撑螺栓应力腐蚀开裂的机理,并提出了核电站抗震支撑螺栓应对应力腐蚀开裂的预防措施.抗震支撑螺栓的应力腐蚀开裂主要是由于螺栓本身受力及特定的化学介质共同作用下,经过一定时间后所产生的脆断现象.通过抗震支撑螺栓应力腐蚀开裂机理的初步分析,希望为核电站进一步对抗震支撑螺栓定期的检查与管理提供有效的帮助,保证了核电站设备安全、稳定的运行.     

基于视觉信息传达的网页界面设计研究

目的探究视觉信息传达影响下的网页界面设计策略。方法以视觉信息传达为导向,结合网页界面设计的基本原则,从主题、色彩、文字、图形图像等方面深入探讨视觉信息传达和网页界面设计的结合。结论网页界面设计应注重视觉导向,合理安排界面中的图形、颜色、文字标记等信息,才能将网页界面调整得更加条理化。     

Fetus-in-fetu with malignant recurrence

Fetus-in-fetu is an unusual condition in which a vertebrate fetus is enclosed within the abdomen of another fetus. These occurrences are usually benign. This report describes an instance of malignant recurrence after resection of a fetus-in-fetu.     

The epidemiological indices of multiple myeloma and concomitant nephropathies

The authors have conducted an epidemiological study for multiple myeloma morbidity and mortality among 80,000 patients of the Medical Center examined in 1988-1995. Myeloma was diagnosed in 65 cases. Standard incidence rate was 4.09, 3.18 and 3.5 per 100,000 for myeloma in males, females and both sexes, respectively. Standard mortality was 2.76 and 1.73 per 100,000 for males and females, respectively. The above rates do not differ much from those of other countries. In terminal myeloma renal insufficiency occurred in 39 of 41 cases. In 8 cases chronic pyelonephritis was an independent course of renal failure thus indicating the importance of its persistent treatment.     

Coexpression of Bcl-2, c-Myc, and p53 oncoproteins as prognostic discriminants in patients with colorectal carcinoma

Lanepitant is a high-affinity, selective neurokinin-1 receptor (NK-1) and is effective in the dural inflammation model of acute migraine. Lanepitant 30, 80, and 240 mg given orally was evaluated in a double-blind, placebo-controlled crossover study to determine its effect in reducing migraine pain and severity of associated symptoms. Outpatients treated four migraine headaches of moderate or severe pain intensity with study drug according to a randomization schedule. They recorded their pain intensity and severity of migraine-associated symptoms at 30, 60, 90, and 120 min. Although 53 patients were randomly allocated to a treatment sequence, only 40 patients completed all treatments. There was no statistically significant difference in improvement in migraine pain at any time for any of the treatments. Additionally, there was no change in severity of migraine-associated symptoms associated with lanepitant therapy. No adverse events could be attributed to lanepitant. Lanepitant was ineffective orally in treating acute migraine in this trial. This may be due to poor bioavailability during a migraine attack. Alternatively, the neurogenic inflammation hypothesis may not apply to migraine.     

Regulation of growth of human diploid fibroblasts by factors elaborated by activated lymphoid cells

Fibroblasts growth synthesis activities appear to be under exquisite control. This control is mediated in part by substances present in blood plasma or released by other cells. We have studied the role of peripheral blood mononuclear cells (PBM) activated with phytohemagglutinin-P (PHA) on DNA synthesis, proliferation, and the cell cycle of human diploid fibroblasts. Culture medium from activated but not from unactivated PBM cultures inhibited fibroblast DNA synthesis and growth in a dose-dependent manner. The activity, which was designated as lymphocyte factor (LF), was very potent; it inhibited 50% of the DNA synthesis and cell growth at a dilution of 1:160. It has a molecular weight between 50,000 and 100,000 daltons and it is destroyed by trypsin digestion or by heating at 80 degrees C for 30 minutes. The activity was not due to the presence of prostaglandin. Furthermore, using immunoprecipitation and affinity chromatography, it was shown conclusively to to be distinctly different from alpha lymphotoxin (alpha-LT). It was not cytotoxic, as shown by the 51chromium release technique. Using flow microfluorimetry it was shown that the activity regulates fibroblast growth by preventing quiescent cells in the G0 or G1 stage of the cell cycle from entering the S phase. Cells already in S at the time of exposure complete DNA synthesis but cannot divide, and they accumulate in G2. The activity also has marked effects on protein synthesis. Activated mononuclear cells may play a major role in regulating fibroblast growth and synthesis in normally healing wounds and in acute and chronic inflammatory processes.