综放工作面垮落带高度测定方法研究

为解决高瓦斯矿井综放工作面垮落带高度难以精确测定,造成工作面两端头难维护、预抽钻孔终孔位置难以确定等问题,依据工作面采动后顶板岩层破断垮落、弯曲下沉对采空区煤层底板施加压力的情况,结合采空区上覆各岩层的厚度和密度,提出了垮落带发育高度的测定方法。以大平矿N1S2综放工作面为例,现场测试结果表明：利用该测定方法测得的垮落带高度为88.65 m,钻孔冲洗液法测得的垮落带高度为88.20 m,二者绝对误差仅为0.45 m。     

Mixed-integer linear programming models for batch sterilization of packaged-foods plants

Batch sterilization with individual retorts is a common mode of operation in many food-canning plants. Although high-speed processing with continuous rotary or hydrostatic retort systems is used in very large canning factories, such systems are not economically feasible in the majority of small- to medium-sized canneries. In such canneries, sterilization is carried out in a battery of retorts as a batch process. Although the unloading and reloading operations for each retort are labor intensive, a well-designed and managed plant can operate with surprising efficiency if it has the optimum number of retorts and scheduling of retort operation. The objective of this research was to present two mathematical models for sterilization scheduling in food-canning plants. The first model developed is for the case where given amount of different canned food products with specific quality requirements would be sterilized within a minimum plant operation time in an autoclave of given capacity. The second model addresses the problem of maximizing the amount of sterilized products in an autoclave of given capacity for given plant operation time. The developed models were based on mixed-integer linear programming and incorporated the possibility of simultaneous sterilization. Simultaneous sterilization applies mainly to small canneries with few retorts. In these situations, retorts often operate with only partial loads because of the small lot sizes, and they are severely under-utilized. In order to demonstrate the feasibility of the mixed-integer linear programming (MILP) models, several examples involving the sterilization of different products were included in this research. The methodology proposed in this study is of special relevance for small- and medium-sized food-canning plants that normally work with many different products at the same time.     

Techniques for monitoring protein misfolding and aggregation in vitro and in living cells

Protein misfolding and aggregation have been considered important in understanding many neurodegenerative diseases and recombinant biopharmaceutical production. Various traditional and modern techniques have been utilized to monitor protein aggregation in vitro and in living cells. Fibril formation, morphology and secondary structure content of amyloidogenic proteins in vitro have been monitored by molecular probes, TEM/AFM, and CD/FTIR analyses, respectively. Protein aggregation in living cells has been qualitatively or quantitatively monitored by numerous molecular folding reporters based on either fluorescent protein or enzyme. Aggregation of a target protein is directly correlated to the changes in fluorescence or enzyme activity of the folding reporter fused to the target protein, which allows non-invasive monitoring aggregation of the target protein in living cells. Advances in the techniques used to monitor protein aggregation in vitro and in living cells have greatly facilitated the understanding of the molecular mechanism of amyloidogenic protein aggregation associated with neurodegenerative diseases, optimizing culture conditions to reduce aggregation of biopharmaceuticals expressed in living cells, and screening of small molecule libraries in the search for protein aggregation inhibitors.     

Mealtime Behaviors and Food Consumption of Perceived Picky and Nonpicky Eaters through Home Use Test

Picky eating has been investigated through numerous surveys and food recalls, but few studies have applied in‐home meal evaluations as a method to investigate behaviors and food preferences of children perceived by their parent to be a picky eater (PE) or nonpicky eater (NPE). A 2‐wk in‐home meal study was completed to investigate differences in PE and NPE mealtime behaviors and food selections using real‐time parental observations. Parents (n = 170) and their 2‐ to 4‐y‐old children (83 PE and 87 NPE) evaluated 5 standardized meals in‐home. Parents recorded their child's and their own hedonic liking of the products and completed an assessment of their child's behavior and consumption at each meal. Significant differences were found between perceived PE and NPE children for all 16 behaviors assessed. On average, perceived NPE were assessed to consume a higher percentage of the meal served and to have higher acceptance scores for most of the foods evaluated. Some foods, though, like breaded chicken and plain pasta, were liked equally by PE and NPE. Several significant differences in hedonic liking were revealed when PE children were compared to their parents. Yet, few differences in liking occurred between NPE children and their parents or between the 2 parental groups. Because study participants evaluated meals real‐time rather than memory recall, the differences and similarities found between perceived PE and NPE may be considered direct experiential evidence with reduced subjective bias as created when subjects recall past experiences. Thus, findings from this study can provide the foundation to establish an objective definition and classification of PE and NPE.     

Drop printing of pharmaceuticals: Effect of molecular weight on PEG coated‐naproxen/PEG 3350 solid dispersions

Solid dispersions have been used to enhance the bioavailability of poorly water‐soluble active pharmaceutical ingredients (APIs). However, the solid‐state phase, compositional uniformity, and scale‐up problems are issues that need to be addressed. To allow for highly controllable products, the drop printing (DP) technique can provide precise dosages and predictable compositional uniformity of APIs in two‐/three‐dimensional structures. DP was used to prepare naproxen (NAP)/polyethylene glycol 3350 (PEG 3350) solid dispersions with PEG coatings of different molecular weights (MWs). A comparison of moisture‐accelerated crystallization inhibition by different PEG coatings was assessed. Scanning electron microscopy, second harmonic generation microscopy, and differential scanning calorimetry analysis were performed to characterize the morphology and quantify the apparent crystallinity of NAP within the solid dispersions. Thermogravimetric analysis was employed to measure the water content within each sample. The results suggest that the moisture‐accelerated crystallization inhibition capability of the PEG coatings increased with increasing MW of the PEG coating. Besides, to demonstrate the flexibility of DP technology on manufacturing formulation, multilayer tablets with different PEG serving as barrier layers were also constructed, and their dissolution behavior was examined. By applying DP and appropriate materials, it is possible to design various carrier devices used to control the release dynamics of the API. © 2015 American Institute of Chemical Engineers AIChE J, 61: 4502–4508, 2015     

焊缝磁光图像全变分模型恢复方法

针对紧密对接微间隙焊缝,研究磁光成像识别的焊缝图像恢复算法,建立基于能量泛函的全变分（Total Variation）图像恢复模型,解决磁光图像退化和清晰度不高的问题.根据偏微分方程论证全变分图像恢复模型解的存在性,将图像恢复过程转化为约束最优化问题,通过泛函变分给出模型的欧拉-拉格朗日方程,对数值近似解的离散形式进行磁光图像恢复.试验分析采用全变分图像恢复模型降噪的同时,保持焊缝图像良好的边缘和纹理特征.结果表明,经全变分模型图像恢复后可有效提高焊缝磁光图像质量,准确地测量焊缝位置.     

STRESS- AND ROTATION-BASED HIERARCHIC MODELS FOR LAMINATED COMPOSITES

A hierarchic sequence of equilibrium models in terms of stresses assumed to be not a priori symmetric is derived for cylindrical bending of laminated composites, using first-order stress functions. The stress field of each hierarchic model satisfies a priori (i) the translational equilibrium equations and the stress boundary conditions of two-dimensional elasticity, and (ii) the continuity requirement for the transverse shear and normal stresses at the lamina interfaces. The levels of hierarchy correspond to the degree to which the two first-order compatibility equations and the rotational equilibrium equation of two-dimensional elasticity are satisfied. The numerical solution is based on Fraeijs de Veubeke's dual mixed variational principle, employing the p-version of the finite element method. The number of degrees of freedom is independent of the number of the layers in the laminate. Results are obtained directly for the stresses and rotations; the displacement field is obtained in the post-processing phase by integration. Numerical results with comparisons show the capability of the mathematical and numerical models proposed.