Recognition of depressed affect in hospitalized psychiatric patients: staff and patient perceptions

A comparison of self-report vs. observer rating of depressed mood in a heterogenous inpatient population revealed wide variations in concordance among diagnostic groups. Patients diagnosed as having Affective Psychosis and "Other' illnesses showed the highest correlation between four self-report scales and an observer rating scale. Patients with a diagnosis of depressive Neurosis showed only modest correlation, while Schizophrenics revealed no significant correlation, on these instruments, suggesting inconsistent communication of affect from Schizophrenic patients to observers. In contrast, when self-report scales were intercorrelated, patients in all four diagnostic categories showed highly significant correlations, indicating that they were consistently reporting their affective state on these instruments. The implications of these findings for future research as well as for practical clinical management are discussed.     

Channel Adaptive Quantization for Limited Feedback MIMO Beamforming Systems

Multiple-input multiple-output (MIMO) wireless systems can achieve significant diversity and array gain by using transmit beamforming and receive combining techniques. In the absence of full channel knowledge at the transmitter, the transmit beamforming vector can be quantized at the receiver and sent to the transmitter using a low-rate feedback channel. In the literature, quantization algorithms for the beamforming vector are designed and optimized for a particular channel distribution, commonly the uncorrelated Rayleigh distribution. When the channel is not uncorrelated Rayleigh, however, these quantization strategies result in a degradation of the receive signal-to-noise ratio (SNR). In this paper, switched codebook quantization is proposed where the codebook is dynamically chosen based on the channel distribution. The codebook adaptation enables the quantization to exploit the spatial and temporal correlation inherent in the channel. The convergence properties of the codebook selection algorithm are studied assuming a block-stationary model for the channel. In the case of a nonstationary channel, it is shown using simulations that the selected codebook tracks the distribution of the channel resulting in improvements in SNR. Simulation results show that in the case of correlated channels, the SNR performance of the link can be significantly improved by adaptation, compared with nonadaptive quantization strategies designed for uncorrelated Rayleigh-fading channels     

Edge-Packing in Planar Graphs

Maximum G Edge-Packing (EPack _G ) is the problem of finding the maximum number of edge-disjoint isomorphic copies of a fixed guest graph G in a host graph H . This paper investigates the computational complexity of edge-packing for planar guests and planar hosts. Edge-packing is solvable in polynomial time when both G and H are trees. Edge-packing is solvable in linear time when H is outerplanar and G is either a 3-cycle or a k -star (a graph isomorphic to K _1,k ). Edge-packing is NP-complete when H is planar and G is either a cycle or a tree with edges. A strategy for developing polynomial-time approximation algorithms for planar hosts is exemplified by a linear-time approximation algorithm that finds a k -star edge-packing of size at least half the optimal. Received May 1995, and in revised form November 1995, and in final form December 1997.     

Normalizing Behavior of Unsaturated Granular Pavement Materials

One of the important components of a flexible pavement structure is granular material layers. Unsaturated granular pavement materials (UGPMs) in these layers influence stresses and strains throughout the pavement structure, and have a large effect on asphalt concrete fatigue and pavement rutting (two of the primary failure mechanisms for flexible pavements). The behavior of UGPMs is dependent on water content, but this effect has been traditionally difficult to quantify using either empirical or mechanistic methods. This paper presents a practical mechanistic framework for determining the behavior of UGPMs within the range of water contents, densities, and stress states likely to be encountered under field conditions. Both soil suction and generated pore pressures are determined and compared to confinement under typical field loading conditions. The framework utilizes a simple soil suction model that has three density-independent parameters, and can be determined using conventional triaxial equipment that is available in many pavement engineering laboratories.     

Distributed associative memory for use in scene analysis

A distributed associative memory system which is ideal for scene analysis is described. Recall of associated patterns using incomplete originals is made possible by the use of a distributed storage mechanism and a novel recall procedure. The memory is shown to store associations between patterns more efficiently than a conventional file store. The paper describes the memory structure, the recall process and its storage abilities, as well as an example of its implementation in hardware.     

Graph embeddings and simplicial maps

An undirected graph is viewed as a simplicial complex. The notion of a graph embedding of a guest graph in a host graph is generalized to the realm of simplicial maps. Dilation is redefined in this more general setting. Lower bounds on dilation for various guest and host graphs are considered. Of particular interest are graphs that have been proposed as communication networks for parallel architectures. Bhattet al. provide a lower bound on dilation for embedding a planar guest graph in a butterfly host graph. Here, this lower bound is extended in two directions. First, a lower bound that applies to arbitrary guest graphs is derived, using tools from algebraic topology. Second, this lower bound is shown to apply to arbitrary host graphs through a new graph-theoretic measure, called bidecomposability. Bounds on the bidecomposability of the butterfly graph and of thek-dimensional torus are determined. As corollaries to the main lower-bound theorem, lower bounds are derived for embedding arbitrary planar graphs, genusg graphs, andk-dimensional meshes in a butterfly host graph.     

The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F

Attachment of an adenovirus (Ad) to a cell is mediated by the capsid fiber protein. To date, only the cellular fiber receptor for subgroup C serotypes 2 and 5, the so-called coxsackievirus-adenovirus receptor (CAR) protein, has been identified and cloned. Previous data suggested that the fiber of the subgroup D serotype Ad9 also recognizes CAR, since Ad9 and Ad2 fiber knobs cross-blocked each other's cellular binding. Recombinant fiber knobs and 3H-labeled Ad virions from serotypes representing all six subgroups (A to F) were used to determine whether the knobs cross-blocked the binding of virions from different subgroups. With the exception of subgroup B, all subgroup representatives cross-competed, suggesting that they use CAR as a cellular fiber receptor as well. This result was confirmed by showing that CAR, produced in a soluble recombinant form (sCAR), bound to nitrocellulose-immobilized virions from the different subgroups except subgroup B. Similar results were found for blotted fiber knob proteins. The subgroup F virus Ad41 has both short and long fibers, but only the long fiber bound sCAR. The sCAR protein blocked the attachment of all virus serotypes that bound CAR. Moreover, CHO cells expressing human CAR, in contrast to untransformed CHO cells, all specifically bound the sCAR-binding serotypes. We conclude therefore that Ad serotypes from subgroups A, C, D, E, and F all use CAR as a cellular fiber receptor.     

Apoptotic induction in transformed follicular lymphoma cells by Bcl-2 downregulation

The roles of Bcl-2 protein and the protein ratio of Bcl-2/Bax in regulating cell growth in various lymphoma cell lines were examined. A dose-dependent decrease in Bcl-2 protein expression was observed in the different lymphomas incubated with lipid-incorporated bcl-2 antisense oligonucleotides (L-bcl-2). Growth inhibition was observed in a transformed follicular lymphoma (FL) cell line, which has the t(14;18) translocation and Bcl-2 protein overexpression. One of the mechanisms by which L-bcl-2 growth inhibition is mediated in these transformed FL cells might be through apoptotic induction, because the treated cells had an increased apoptotic index and showed the typical DNA fragmentation. These studies indicate that Bcl-2 protein is critical in the growth regulation of transformed FL cells. L-bcl-2 did not induce growth inhibition in lymphoma cells not expressing Bcl-2 or Bax protein. Thus, the protein ratio of Bcl-2/Bax may also be important in regulating the growth of these lymphomas.