全文获取类型
收费全文 | 2855篇 |
免费 | 11篇 |
专业分类
电工技术 | 10篇 |
化学工业 | 44篇 |
金属工艺 | 9篇 |
机械仪表 | 14篇 |
建筑科学 | 36篇 |
能源动力 | 7篇 |
轻工业 | 31篇 |
水利工程 | 6篇 |
石油天然气 | 2篇 |
无线电 | 33篇 |
一般工业技术 | 66篇 |
冶金工业 | 2525篇 |
原子能技术 | 2篇 |
自动化技术 | 81篇 |
出版年
2021年 | 4篇 |
2020年 | 6篇 |
2019年 | 4篇 |
2018年 | 4篇 |
2017年 | 6篇 |
2016年 | 4篇 |
2015年 | 4篇 |
2014年 | 6篇 |
2013年 | 18篇 |
2012年 | 14篇 |
2011年 | 29篇 |
2010年 | 13篇 |
2009年 | 18篇 |
2008年 | 27篇 |
2007年 | 17篇 |
2006年 | 14篇 |
2005年 | 10篇 |
2004年 | 19篇 |
2003年 | 15篇 |
2002年 | 6篇 |
2001年 | 8篇 |
2000年 | 5篇 |
1999年 | 92篇 |
1998年 | 852篇 |
1997年 | 497篇 |
1996年 | 267篇 |
1995年 | 174篇 |
1994年 | 136篇 |
1993年 | 149篇 |
1992年 | 18篇 |
1991年 | 21篇 |
1990年 | 25篇 |
1989年 | 31篇 |
1988年 | 25篇 |
1987年 | 26篇 |
1986年 | 15篇 |
1985年 | 14篇 |
1984年 | 5篇 |
1983年 | 8篇 |
1982年 | 8篇 |
1981年 | 26篇 |
1980年 | 14篇 |
1979年 | 3篇 |
1978年 | 7篇 |
1977年 | 49篇 |
1976年 | 115篇 |
1975年 | 7篇 |
1973年 | 7篇 |
1972年 | 3篇 |
1955年 | 3篇 |
排序方式: 共有2866条查询结果,搜索用时 0 毫秒
61.
MA Piplani DG Disler TR McCauley TJ Holmes JP Cousins 《Canadian Metallurgical Quarterly》1996,198(3):855-859
PURPOSE: To determine the accuracy of semiautomated quantification of articular cartilage volume from three-dimensional (3D) reformations of magnetic resonance (MR) images. MATERIALS AND METHODS: Sagittal, fat-suppressed, 3D, spoiled gradient-recalled-echo MR imaging of two bovine and two human cadaver knees was performed. Articular cartilage volume was calculated from 3D reformations of the MR images by using a semiautomated program written at the authors' institution. Calculated volumes were compared with directly measured volumes of the surgically removed articular cartilage. RESULTS: The percentage of error of the MR imaging-determined volumes was 6.53% +/- 4.75 (mean +/- standard deviation). A strong correlation between the two sets of observations was shown (r=.997). Linear regression showed the calculated volumes to be highly accurate (slope=1.002, P>.25). Repeated reformations yielded volumes that were reproducible (mean absolute error, 0.013 mL +/- 0.019) and not significantly different from the measured volume (P>.10). CONCLUSION: Semiautomated quantification of knee articular cartilage from MR images yields highly accurate cartilage volumes. 相似文献
62.
K Basen-Engquist GS Parcel R Harrist D Kirby K Coyle S Banspach D Rugg 《Canadian Metallurgical Quarterly》1997,67(9):365-371
Randomized trials of school-based health promotion programs present unique design and analytical issues not widely discussed in the research literature. This article describes the Safer Choices study--a school-based program for prevention of HIV, other sexually transmitted diseases, and pregnancy--to illustrate critical methodological issues involved in large-scale, school-based intervention trials, particularly those evaluating interventions with a school-wide focus. The issues presented are: 1) comparability of the intervention and control groups even when few units are randomized; 2) factors that affect the decision to use a cohort or cross-sectional design; and 3) appropriate analysis strategy when the unit of randomization and intervention is at the school level, but observations are at the student level. 相似文献
63.
James King Sergey Yakovlev Zhisong Fu Robert M. Kirby Spencer J. Sherwin 《Journal of scientific computing》2014,60(2):457-482
Numerical methods for elliptic partial differential equations (PDEs) within both continuous and hybridized discontinuous Galerkin (HDG) frameworks share the same general structure: local (elemental) matrix generation followed by a global linear system assembly and solve. The lack of inter-element communication and easily parallelizable nature of the local matrix generation stage coupled with the parallelization techniques developed for the linear system solvers make a numerical scheme for elliptic PDEs a good candidate for implementation on streaming architectures such as modern graphical processing units (GPUs). We propose an algorithmic pipeline for mapping an elliptic finite element method to the GPU and perform a case study for a particular method within the HDG framework. This study provides comparison between CPU and GPU implementations of the method as well as highlights certain performance-crucial implementation details. The choice of the HDG method for the case study was dictated by the computationally-heavy local matrix generation stage as well as the reduced trace-based communication pattern, which together make the method amenable to the fine-grained parallelism of GPUs. We demonstrate that the HDG method is well-suited for GPU implementation, obtaining total speedups on the order of 30–35 times over a serial CPU implementation for moderately sized problems. 相似文献
64.
Shen TJ; Ho NT; Zou M; Sun DP; Cottam PF; Simplaceanu V; Tam MF; Bell DA Jr; Ho C 《Protein engineering, design & selection : PEDS》1997,10(9):1085-1097
A hemoglobin expression system in Escherichia coli is described. In order
to produce authentic human hemoglobin, we need to co-express both
methionine aminopeptidase and globin genes under the control of a strong
promoter. We have constructed three plasmids, pHE2, pHE4 and pHE7, for the
expression of human normal adult hemoglobin and a plasmid, pHE9, for the
expression of human fetal hemoglobin, in high yields. The globin genes can
be derived from either synthetic genes or human globin cDNAs. The extra
amino-terminal methionine residues of the expressed globins can be removed
by the co-expressed methionine aminopeptidase. The heme is inserted
correctly into the expressed alpha- globin from our expression plasmids. A
fraction (approximately 25%) of the heme is not inserted correctly into the
expressed beta- or gamma- globin. However, the incorrectly inserted hemes
can be converted into the correct conformation by carrying out a simple
oxidation-reduction process on the purified hemoglobin molecule. We have
investigated the functional properties of the expressed hemoglobins by
measuring their oxygen-binding properties and their structural features by
obtaining their 1H-NMR spectra. Our results show that authentic human
normal adult and fetal hemoglobins can be produced from our expression
plasmids in E. coli and in high yields. Our expression system allows us to
design and to produce any recombinant hemoglobins needed for our research
on the structure-function relationship in hemoglobin.
相似文献
65.
Sowdhamini R; Mitchell TJ; Andrew PW; Morgan PJ 《Protein engineering, design & selection : PEDS》1997,10(3):207-215
Pneumolysin and proaerolysin are bacterial toxins that form pores in host
cells by oligomerization. We propose that they may have similar structures
despite a poor sequence identity. The crystal structure of proaerolysin
reveals a protein composed of four domains, arranged in the shape of an
elongated comma. Electron microscopy of the pneumolysin monomer shows a
similar arrangement of domains. The sequence of pneumolysin recognizes the
template of proaerolysin from a library of protein folds. A
three-dimensional model of pneumolysin has been constructed by the
comparative approach using the structure of proaerolysin. This model,
together with results on the activity of site- specific mutants and the
positions of antigenic sites, has been used to propose functional roles of
individual domains.
相似文献
66.
67.
BACKGROUND: Increasing concentrations of desflurane result in progressive decreases in blood pressure (BP) and, unlike other currently marketed, potent volatile anesthetics, heightened sympathetic nervous system activity. This study aimed to determine whether baroreflex mechanisms are involved in desflurane-mediated sympathetic excitation. METHODS: Healthy volunteers were anesthetized with desflurane (n = 8) or isoflurane (n = 9). Heart rate (HR; measured by electrocardiograph), blood pressure (BP; measured by arterial catheter), and efferent sympathetic nerve activity (SNA; obtained from percutaneous recordings from the peroneal nerve) were monitored. Baroreflex sensitivity was evaluated at baseline while volunteers were conscious and during 0.5, 1, and 1.5 minimum alveolar concentration (MAC) anesthesia via bolus injections of nitroprusside (100 microg) and phenylephrine (150 microg) to decrease and increase BP. To prevent the BP decline with increasing depths of anesthesia, phenylephrine was infused to maintain mean BP at the 0.5 MAC level. RESULTS: The HR, BP, and SNA were similar between the groups at the conscious baseline measurement. Efferent SNA did not change during higher MAC of isoflurane, but it increased progressively as desflurane concentrations were increased beyond 0.5 MAC, despite maintaining BP at the 0.5 MAC value with phenylephrine infusions (P < 0.05). Cardiac baroslopes (based on changes in HR) were progressively and similarly decreased with increasing concentrations of isoflurane and desflurane (P < 0.05). Sympathetic baroslopes (based on SNA) decreased with increasing isoflurane concentrations but were maintained with increasing concentrations of desflurane; the response was significantly different between groups. CONCLUSIONS: The increase in basal levels of SNA with increasing concentrations of desflurane persisted despite "fixing" BP and thus is probably not due to hypotension and unloading of the baroreceptors. Further, the preservation of reflex increases in SNA to nitroprusside during desflurane indicates that desflurane preserves one component of the baroreflex in humans when BP is "fixed." 相似文献
68.
A solid-state 2H NMR study of methyl-d3-cobalamin has been performed as a function of temperature to provide information concerning the character and energetics of the motion performed by this unique bioorganometallic methyl group. Analysis of the 2H NMR line shape indicates that the methyl group undergoes rapid three-fold rotation, and that the Co-C-2H angle lies between 105.9 and 109.5 degrees. Determination of the spin-lattice relaxation times T1 shows that the relaxation is anisotropic, consistent with a "jumping" motion of the methyl group rather than rotational diffusion. This also provides the activation energy to methyl jumps as 8.3 +/- 1.3 kJ/mol. It is proposed that this energetic barrier may be a useful probe of changes in the electronic character of the Co-C bond that accompany the biological role of this molecule in such enzymes as methionine synthase. 相似文献
69.
DI Blyth MS Pedrick TJ Savage H Bright JE Beesley S Sanjar 《Canadian Metallurgical Quarterly》1998,19(1):38-54
70.
TJ Babineau W Swails Bollinger RA Forse BR Bistrian 《Canadian Metallurgical Quarterly》1998,228(5):701-706
Background electrolyte (BGE) systems with two coions are frequently used in capillary zone electrophoresis (CZE), especially in cases where indirect optical detection is employed. This study investigates the behavior of analytes, which possess mobilities intermediate to those of the BGE coions used. Besides the expected behavior, where the analytes provide either tailing or fronting zones, unusual behavior with extraordinary zone broadening is also observed in some cases. The explanation for this effect is that binary BGE systems involve, as a physico-chemical rule, a region where the analytes are forced by one coion to give tailing zones and simultaneously by the other coion to give fronting zones. The result of this "schizophrenic" situation is extraordinary zone broadening and deterioration of the detection record. A series of experiments is presented showing in a telling way the electromigration behavior of the discussed type of zones as well as the ways to remedy the deterioration of the peak shape by a mere slight changing of the quantitative composition of the BGE used. 相似文献