Bypass surgery for vascular disease of the carotid system

A series of 58 operations on 56 patients, in whom a branch of the superficial temporal artery was anastomosed to a branch of the middle cerebral artery (STA-MCA bypass or Yasargil procedure), is reviewed. These operations were performed chiefly for occlussions or for inaccessible stenotic lesions of the internal carotid or middle cerebral arteries. Patency in eight patients operated on from April 1971 through November 1973 was low (25%). Patency in patients operated on since July 1974 has been high (95%). There have been no deaths and no major ischemic strokes attributable to the surgery. The rationale for this procedure is considered in relationship to the anatomy and physiology of the cerebral circulation and the pathogenesis of syndromes of cerebral ischemia. The operation appears to have a low morbidity in good-risk patients. The role of this operation in managing common manifestations of cerebral vascular disease such as focal transient cerebral ischemic attacks (TIAs) and amaurosis fugax, although not fully established, appears encouraging. The procedure seems useful for orthostatic cerebral ischemia caused by multiple occlusions of major extracranial (and intracranial) vessels and, occasionally, for progressing strokes related to internal carotid artery occlusion, both of which are relatively uncommon manifestations of cerebral vascular occlusive disease. It may have application in the rare "slow stroke." The procedure is probably of limited value, if any, in the management of large completed infarcts but may be indicated in selected patients with small infarctions who have preserved most of their cerebral function and who have had evidence of subsequent focal ischemic events. The procedure is useful for bypassing giant aneurysms or basofrontal tumors invading major vessels. It may have a role in the management of fibromuscular disease of the internal carotid artery.     

Decreased resistance to intravenous tumour-cell challenge during reticuloendothelial depression following surgery

The influence of surgical stress on resistance to i.v. challenge with Walker 256 tumour cells was investigated in rats, with respect to the functional state of the reticuloendothelial system (RES). Phagocytic activity of the RES was evaluated by colloid (gelatinized [131I] "RE test lipid emulsion") clearance, and opsonin levels were determined by bioassay. Reticuloendothelial clearance capacity was significantly (P less than 0-05) depressed 60 min following surgery (coeliotomy plus jejunal enterotomy) as quantified by both humoral and cellular parameters of RE function. Phagocytic depression was primarily due to impaired hepatic Kupffer cell function and related to a deficiency in the phagocytic supporting capacity of plasma, also referred to as opsonic or recognition factor (RF) capacity. During the postoperative period of RES colloid clearance depression, pulmonary localization of the blood-borne test particulate matter increased. Rats challenged with 51Cr-labelled viable tumour cells at a dose of 1-0 X 106 i.v., either prior to or during the postoperative period of RE depression, manifested a significant (P less than 0-05) increment in pulmonary localization of the viable tumour cells, and a decrease (P less than 0-05) in hepatic clearance. Evaluation of survival patterns demonstrated a significant (P less than 0-01) decrease in host resistance to i.v. tumour cell challenge (2 X 103 cells) during the postoperative period of RE depression and hypo-opsonaemia. Sham-anaesthetized control animals survived 17-9 +/- 0-8 days, while animals challenged during the period of RE depression survived 7-9 +/- 0-4 days. An increased incidence of respiratory distress and nasal discharge was observed in the animals with impaired survival. Thus, surgical manipulation may transiently compromise RES systemic host defence and may be reflected in an increment in the pulmonary localization of blood-borne tumour cells. The relationship of this altered pattern of tumour cell distribution to the impaired survival remains to be determined, and warrants investigations.     

Inside Front Cover: Towards See‐Through Displays: Fully Transparent Thin‐Film Transistors Driving Transparent Organic Light‐Emitting Diodes (Adv. Mater. 6/2006)

The first fully transparent organic light‐emitting diode (OLED) pixels, fabricated by integrating transparent OLEDs on top of transparent thin‐film transistors (TTFTs), are demonstrated on p. 738 by Riedl and co‐workers, and shown schematically on the inside cover. With an average transmittance of more than 70 % in the visible part of the spectrum (400–750 nm), the presented active pixels pave the way to the realization of fully transparent active matrix displays.     

Functional Projection: How Fundamental Social Motives Can Bias Interpersonal Perception.

Results from 2 experimental studies suggest that self-protection and mate-search goals lead to the perception of functionally relevant emotional expressions in goal-relevant social targets. Activating a self-protection goal led participants to perceive greater anger in Black male faces (Study 1) and Arab faces (Study 2), both out-groups heuristically associated with physical threat. In Study 2, participants' level of implicit Arab-threat associations moderated this bias. Activating a mate-search goal led male, but not female, participants to perceive more sexual arousal in attractive opposite-sex targets (Study 1). Activating these goals did not influence perceptions of goal-irrelevant targets. Additionally, participants with chronic self-protective and mate-search goals exhibited similar biases. Findings are consistent with a functionalist, motivation-based account of interpersonal perception. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The boundary finite element method for predicting directions of cracks emerging from notches at bimaterial junctions

The analysis of a bimaterial medium with various notch opening angles has been carried out using boundary finite element method (BFEM) under arbitrary loading conditions. Introduced as novel method for stress concentration problems at geometrical discontinuities, cracks, bimaterial notches etc., the BFEM has been proved as numerically highly efficient. This has become more and more important because wedge type construction creates stress concentrations which may lead to crack initiation in many practical situations where multi-layered composite material is used, e.g. within aerospace, ship or automobile structures. So, the computational prediction of potential directions for crack initiation is essential for the knowledge of weak regions. All the analysis results are based on the hypothesis of Erdogan and Sih and have been verified by the well established finite element method. Results for potential crack initiation angles of both homogeneous and bimaterial media are presented with multiple examples of different wedge angles and different loading combinations.     

Distributed computing for multidisciplinary design optimization using Java

The programming language Java (recently referred to as the computer language of the Web) offers substantial possibilities for the type of complex engineering problems typically encountered in multidisciplinary design optimization (MDO) problems. In order to demonstrate the potential uses of Java for MDO problems, this paper presents the development of the Web Interface for complex engineering design (WICkED) software, which simulates the convergence of a decomposed complex system in a distributed computing environment and computes the sensitivity derivatives of the system with respect to the independent input variables using the GSE method or the finite difference method. In this application, one computer is designated as the server and sends out required inputs to a number of client subsystems over the Internet. A number of client computers can connect to the server and then receive the inputs necessary to calculate the solution to their model. As the code necessary to solve the model already exists at the client, only the inputs have to be sent over the network. When the client has solved the calculation, it returns the results to the server which processes the result to produce new inputs.WICkED is written entirely in the Java programming language which allows server and clients to exist on completely different computer types and in heterogeneous, distributed networks. A number of parametric studies on the behaviour of complex systems in a distributed environment are performed and the results are reported in this paper. This research serves to identify potential problems as well as advantages in using Java for MDO applications.     

Heat transfer coefficients for forced-air cooling and freezing of selected foods

To maximize the efficiency of cooling and freezing operations for foods, it is necessary to optimally design the refrigeration equipment to fit the specific requirements of the particular cooling or freezing application. The design of food refrigeration equipment requires estimation of the cooling and freezing times of foods, as well as the corresponding refrigeration loads. The accuracy of these estimates, in turn, depends upon accurate estimates of the surface heat transfer coefficient for the cooling or freezing operation. This project reviewed heat transfer data for the cooling and/or freezing of foods. A total of 777 cooling curves for 295 food items were obtained from an industrial survey and a unique iterative algorithm, utilizing the concept of ‘equivalent heat transfer dimensionality’, was developed to obtain heat transfer coefficients from these cooling curves. Nine Nusselt–Reynolds–Prandtl correlations were developed from a selection of the 777 heat transfer coefficients resulting from this algorithm, as well as 144 heat transfer coefficients for 13 food items, collected from the literature. The data and correlations resulting from this project will be used by designers of cooling and freezing systems for foods. This information will make possible a more accurate determination of cooling and freezing times and corresponding refrigeration loads. Such information is important in the design and operation of cooling and freezing facilities and will be of immediate usefulness to engineers involved in the design and operation of such systems.     

Effective stiffness and microscopic deformation of an orthotropic plate containing arbitrary holes

Many engineering materials and structures, such as cellular structures, sandwich core structures and laminated plates with holes, can be modeled by an inclusion problem with anisotropic matrix. The paper studies the effective properties and the microscopic deformation of anisotropic plates with periodic holes by using direct and mathematical homogenization. The effective stiffnesses are calculated by different homogenization methods and the microscopic deformation of a RVE is modeled by the finite element method for the plate with arbitrarily shaped holes. All of the effective stiffness coefficients, especially stretching-shear coupling coefficients are evaluated.     

A simplified analysis of the effect of microstructure gradient on the stress relief of aluminum plates and extrusions

Many bulk forms of metal products are quenched after heat treatment in order to preserve material characteristics. Rapid quenching results in large thermal stress gradients that lead to high levels of residual stress. For products such as plates and extrusions, stretching by a few percent can reduce these stresses, but the stresses are not completely relieved. This report presents a simplified analytical model of the stress relief process illustrating the effects of through-thickness property gradients on residual stress after stretching. The basic conclusion is that for plates with uniform yield surface shapes through the thickness, the through-thickness residual stress range after stress relief is equal to the strength range in the direction of stretch. In extrusions, the bow after stress relief is proportional to this strength range. Cases are also considered in which the yield surface shapes range from isotropic to anisotropic through the thickness. Plastic anisotropy can perturb the effect of strength range on residual stress.