Insulin depletion leads to adipose-specific cell death in obese but not lean mice

Mutation of the obese gene produces obesity, hyperinsulinemia, and compensatory "overexpression" of the defective gene. As insulin activates obese gene expression, it seemed possible that hyperinsulinemia might be responsible for overexpression of the gene. To address this question we rapidly neutralized circulating insulin by injection of an insulin antibody. Unexpectedly, insulin depletion in obese (ob/ob or db/db) mice caused massive adipose RNA degradation confirmed by histological analysis to result from adipocyte cell death by a largely necrotic mechanism. This effect was not observed in lean littermates and was completely corrected by coadministration of insulin. Comparison of multiple tissues demonstrated that the effect was restricted to adipose tissue. Insulin depletion in obese mice by administration of streptozotocin also led to cell death, but this death was less extensive and appeared to be apoptotic in mechanism. Thus insulin may promote the survival side of the physiological balance between adipocyte survival and death.     

A reversible data hiding scheme using complementary embedding strategy

Obtaining good visual quality and high hiding capacity with reversible data hiding systems is a technically challenging problem. In this paper, we propose a simple reversible data hiding scheme that uses a complementary hiding strategy. The proposed method embeds one secret bit horizontally and vertically into one cover pixel of a grayscale cover image by decreasing odd-valued pixels and increasing even-valued pixels by one. Experimental results show that the hiding capacity measured by bit per pixel (bpp) of the proposed scheme is at least 1.21 bpp with a PSNR (peak signal-to-noise ratio) value greater than 52 dB for all standard test images. Especially in the case of four-layer embedding, the PSNR value of the proposed method is still greater than 51 dB at a hiding capacity of about 5 bpp for all standard test images. In addition, the proposed method is quite simple because it primarily uses additions and subtractions. These results indicate that the proposed scheme is superior to many existing reversible data hiding schemes introduced in the literature.     

Dissipative particle dynamics simulations for fibre suspensions in newtonian and viscoelastic fluids

A versatile model of fibre suspensions in Newtonian and viscoelastic fluids has been developed using dissipative particle dynamics method. The viscoelastic fluid is modelled by linear chains with linear connector spring force (the Oldroyd-B model), which is known to be a reasonable model for the so-called Boger fluid (a dilute suspension of polymer in a highly viscous solvent). The numerical results are in excellent agreement with the analytical results of the Oldroyd-B model in simple shear flow. An effective meso-scale model of fibre in DPD is proposed and then incorporated with simple Newtonian fluid and our Boger fluid to enable entirely study rheological properties of fibre suspensions in both Newtonian and viscoelastic solvents. The numerical results are well compared with available experimental data and other numerical models.     

Improving traversability of quadruped walking robots using body movement in 3D rough terrains

This paper presents a study on improving the traversability of a quadruped walking robot in 3D rough terrains. The key idea is to exploit body movement of the robot. The position and orientation of the robot are systematically adjusted and the possibility of finding a valid foothold for the next swing is maximized, which makes the robot have more chances to overcome the rough terrains. In addition, a foothold search algorithm that provides the valid foothold while maintaining a high traversability of the robot, is investigated and a gait selection algorithm is developed to help the robot avoid deadlock situations. To explain the algorithms, new concepts such as reachable area, stable area, potential search direction, and complementary kinematic margin are introduced, and the effectiveness of the algorithms is validated via simulations and experiments.     

A dispatching method for automated lifting vehicles in automated port container terminals

In automated container terminals, containers are transported from the marshalling yard to a ship and vice versa by automated vehicles. The automated vehicle type studied in this paper is an automated lifting vehicle (ALV) that is capable of lifting a container from the ground by itself. This study discusses how to dispatch ALVs by utilizing information about pickup and delivery locations and time in future delivery tasks. A mixed-integer programming model is provided for assigning optimal delivery tasks to ALVs. A procedure for converting buffer constraints into time window constraints and a heuristic algorithm for overcoming the excessive computational time required for solving the mathematical model are suggested. Numerical experiments are reported to compare the objective values and computational times by a heuristic algorithm with those by an optimizing method and to analyze the effects of dual cycle operation, number of ALVs, and buffer capacity on the performance of ALVs.     

Tool path smoothing of a redundant machine: Application to Automated Fiber Placement

Automated Tape Laying and Fiber Placement of composite materials are the two principal automated processes used for fabrication of large composite structures in aeronautical industry. The aluminum parts produced by High Speed Machining tend to be replaced by carbon fiber composite parts realized with these processes. However, structural parts present reinforcement zones which disturb the tool path follow-up and generate an increase of the manufacturing time. Thus, this paper deals with the optimization of tool paths of a 7-axis machine tool of Fiber Placement with the objective of reducing the manufacturing time while ensuring the requested quality of the final part. In this paper, two complementary methods are detailed. The first method takes advantage of the degree of redundancy of the machine tool to decrease the kinematic loads of the control joints. The second method aims to smooth the orientation of the machine head along the tool path while ensuring quality constraints. These two methods are then applied on a test tool path and bring to a significant decrease of the manufacturing time (32.9%).     

Stability radius of implicit dynamic equations with constant coefficients on time scales

This paper deals with the stability radii of implicit dynamic equations on time scales when the structured perturbations act on both the coefficient of derivative and the right-hand side. Formulas of the stability radii are derived as a unification and generalization of some previous results. A special case where the real stability radius and the complex stability radius are equal is studied. Examples are derived to illustrate results.     

Variants of fractionation of irradiation in intracavitary gamma-therapy

Under study was the efficacy of three schedules of dose fractionation in intracavitary gamma-therapy in cervical cancer patients treated on the machine "AGAT-B". Single doses were 1000, 700 and 500 rad, while total dosage at point A depending on the stage of the disease was within the range of 4000-5000 rad. The survival during the first, second and third years following termination of the radiotherapy was found to be identical for patients of all the groups under examination. No differences were noted in them also in the character of early radiation reactions on the part of the adjacent organs. The frequency and severity of late radiation injuries of the urinary bladder, rectum and vagina were related to the dose fractionation regimen.     

Local Convergence of the Lavrentiev Method for the Cauchy Problem via a Carleman Inequality

The purpose is to perform a sharp analysis of the Lavrentiev method applied to the regularization of the ill-posed Cauchy problem, set in the Steklov-Poincaré variational framework. Global approximation results have been stated earlier that demonstrate that the Lavrentiev procedure yields a convergent strategy. However, no convergence rates are available unless a source condition is assumed on the exact Cauchy solution. We pursue here bounds on the approximation (bias) and the noise propagation (variance) errors away from the incomplete boundary where instabilities are located. The investigation relies on a Carleman inequality that enables enhanced local convergence rates for both bias and variance errors without any particular smoothness assumption on the exact solution. These improved results allows a new insight on the behavior of the Lavrentiev solution, look similar to those established for the Quasi-Reversibility method in [Inverse Problems 25, 035005, 2009]. There is a case for saying that this sort of ??super-convergence?? is rather inherent to the nature of the Cauchy problem and any reasonable regularization procedure would enjoy the same locally super-convergent behavior.     

Bypass surgery for vascular disease of the carotid system

A series of 58 operations on 56 patients, in whom a branch of the superficial temporal artery was anastomosed to a branch of the middle cerebral artery (STA-MCA bypass or Yasargil procedure), is reviewed. These operations were performed chiefly for occlussions or for inaccessible stenotic lesions of the internal carotid or middle cerebral arteries. Patency in eight patients operated on from April 1971 through November 1973 was low (25%). Patency in patients operated on since July 1974 has been high (95%). There have been no deaths and no major ischemic strokes attributable to the surgery. The rationale for this procedure is considered in relationship to the anatomy and physiology of the cerebral circulation and the pathogenesis of syndromes of cerebral ischemia. The operation appears to have a low morbidity in good-risk patients. The role of this operation in managing common manifestations of cerebral vascular disease such as focal transient cerebral ischemic attacks (TIAs) and amaurosis fugax, although not fully established, appears encouraging. The procedure seems useful for orthostatic cerebral ischemia caused by multiple occlusions of major extracranial (and intracranial) vessels and, occasionally, for progressing strokes related to internal carotid artery occlusion, both of which are relatively uncommon manifestations of cerebral vascular occlusive disease. It may have application in the rare "slow stroke." The procedure is probably of limited value, if any, in the management of large completed infarcts but may be indicated in selected patients with small infarctions who have preserved most of their cerebral function and who have had evidence of subsequent focal ischemic events. The procedure is useful for bypassing giant aneurysms or basofrontal tumors invading major vessels. It may have a role in the management of fibromuscular disease of the internal carotid artery.