Coexpression of Bcl-2, c-Myc, and p53 oncoproteins as prognostic discriminants in patients with colorectal carcinoma

Lanepitant is a high-affinity, selective neurokinin-1 receptor (NK-1) and is effective in the dural inflammation model of acute migraine. Lanepitant 30, 80, and 240 mg given orally was evaluated in a double-blind, placebo-controlled crossover study to determine its effect in reducing migraine pain and severity of associated symptoms. Outpatients treated four migraine headaches of moderate or severe pain intensity with study drug according to a randomization schedule. They recorded their pain intensity and severity of migraine-associated symptoms at 30, 60, 90, and 120 min. Although 53 patients were randomly allocated to a treatment sequence, only 40 patients completed all treatments. There was no statistically significant difference in improvement in migraine pain at any time for any of the treatments. Additionally, there was no change in severity of migraine-associated symptoms associated with lanepitant therapy. No adverse events could be attributed to lanepitant. Lanepitant was ineffective orally in treating acute migraine in this trial. This may be due to poor bioavailability during a migraine attack. Alternatively, the neurogenic inflammation hypothesis may not apply to migraine.     

Cold-cathode emitter based on a metal-diamond tunneling junction

Recently Geis fabricated a composite cold cathode emitter made of diamond doped by substitutional nitrogen on a roughened metallic substrate, which is characterized by high field emission currents at very low power. Using an internal field emission mechanism through the Schottky barrier at the metal diamond interfaces to populate the conduction band of diamond, we have developed a quantitative theory to describe the operation of such a device. The calculated I-V characteristics are in good agreement with the experimental results of Geis, et al     

Gamma interferon is not essential in host defense against disseminated candidiasis in mice

Apoptosis is well known to be mediated by oxidative stress. To evaluate the functional role of reactive oxygen intermediates (ROI) produced by neutrophils, we compared the rates of apoptosis in neutrophils isolated from normal donors and from patients with chronic granulomatous disease (CGD), a hereditary defect in ROI production. Spontaneous cell death in CGD neutrophils in vitro was significantly inhibited relative to normal neutrophils. The acceleration of apoptosis induced by anti-Fas monoclonal antibody (MoAb) in CGD neutrophils was much slower than that seen in normal neutrophils. These findings suggest that the apoptosis of neutrophils may be mediated by endogenous oxidative products. This suggestion was confirmed by observation that apoptosis of normal neutrophils was markedly inhibited by reduction of intracellular levels of hydrogen peroxide (H2O2). The inhibition of apoptosis in normal neutrophils by adding catalase occurred regardless of the presence of anti-Fas MoAb. H2O2 increased both spontaneous apoptosis and Fas-mediated apoptosis of the CGD neutrophils in proportion to that seen in normal neutrophils. Although several factors that mediate the apoptosis of neutrophils remain to be determined, these results suggest that ROI are major mediators of the apoptosis in neutrophils and may be involved in Fas-mediated signal transduction pathway.     

Getting along and getting ahead: Empirical support for a theory of protective and acquisitive self-presentation.

Study 1, with 386 undergraduates, demonstrated that the Concern for Appropriateness Scale and the Revised Self-Monitoring Scale (SMS—R) developed by the 1st 2 authors (see record 1984-27678-001) were orthogonal and that they were predictably related to measures of self-esteem, social anxiety, shyness, and sociability. Study 2, with an additional 249 Ss, showed that Ss high in concern for appropriateness tended to describe their own drug use as due to inducement by others, whereas Ss who scored high on the SMS—R tended to describe their drug use as self-initiated. (29 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cloning in silico

Cellulose is a major component of plant cell walls, but identification of the enzymes that synthesize it has proven difficult. Now, however, several candidate proteins with sequence homology to bacterial cellulose synthases have been identified by partial sequencing of anonymous cDNA clones from cotton fibers.     

A comparison of Japanese and US high-technology transfer practices

Some empirical results and observations are presented which describe the principal ways in which a sample of industrial researchers in Japan and in the US utilize certain technologies resulting from university research. The findings are from a survey conducted in Japan and the US between October 1986 and December 1987. These results indicate that personal communications and technical collaboration are the key factors in the rapid diffusion of research results in both countries, and that in Japan, government agencies and professional societies take a much more active role in organizing and energizing the civilian technology-transfer process than do counterpart organizations in the US