Dynamic digital holographic wavelength filtering

This paper describes the theory and results of a new generic technology for use in optical telecommunications and wavelength division multiplexing (WDM): dynamic digital holographic wavelength filtering. The enabling component is a polarization-insensitive ferroelectric liquid crystal (FLC) spatial light modulator (SLM) in conjunction with a highly wavelength-dispersive fixed diffractive element. The technology has been used to perform demultiplexing of single or multiple WDM signals, dynamic erbium doped fiber amplifier (EDFA) gain equalization and channel management, and used to tune an erbium-doped fiber laser (EDFL) functioning as a high power, very narrow linewidth WDM source     

Evidence for an essential non-Watson-Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron

Nuclear pre-messenger RNA splicing requires the action of five small nuclear (sn) RNAs, U1, U2, U4, U5 and U6, and more than 50 proteins. The mechanistic similarity of nuclear pre-mRNA splicing and group II self-splicing suggests that many of the central processes of nuclear pre-mRNA splicing are based on RNA-RNA interaction. To understand the mechanism of pre-mRNA splicing, the interactions, and their temporal relationships, that occur between the snRNAs and the pre-mRNA during splicing must be identified. Several snRNA-snRNA and snRNA-intron interactions have been demonstrated but the putative RNA-based interactions that recognize the AG dinucleotide at the 3' splice site during 3' cleavage and exon ligation are unknown. We report here the reciprocal suppression between 5' and 3' splice site mutations in the yeast actin intron, and propose that the 3' splice site is positioned for 3' cleavage and exon ligation, at least in part, through a non-Watson-Crick interaction between the guanosines at the 5' and 3' splice sites.     

The "difference of means" may not be the "effect size".

Comments on J. Cohen's (see record 1995-12080-001) article with the purpose of restraining enthusiasm for the report of effect size in the form of a confidence interval for the differences of means, rather than the null hypothesis significance testing declaration that the effect size is not zero. Three examples are given in which measurement of effect sizes in the scale of the dependent variable tells researchers little that they need to know. It is suggested that better information might be obtained from effect sizes measured using the d statistic. (N. Cliff; see record 1994-08169-001). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Residual phase noise measurements of VHF, UHF, and microwavecomponents

The results of residual phase noise measurements on a number of VHF, UHF, and microwave amplifiers, both silicon (Si) bipolar junction transistor (BJT) and gallium arsenide (GaAs) field effect transistor (FET) based, electronic phase shifters, frequency dividers and multipliers, etc., which are commonly used in a wide variety of frequency source and synthesizer applications are presented. The measurement technique has also been used to evaluate feedback oscillator components, such as the loop and buffer amplifiers, which can play important roles in determining an oscillator's output phase noise spectrum (often in very subtle ways). While some information has previously been published related to component residual phase noise properties, it generally focused on the flicker noise levels of the devices under test, for carrier offset frequencies less than 10 kHz. The work reported herein makes use of an extremely low noise, 500 MHz surface acoustic wave resonator oscillator (SAWRO) test source for residual phase noise measurements, both close-to-and far-from-the-carrier. Using this SAWRO-based test source at 500 MHz, we have been able to achieve a measurement system phase noise floor of -184 dBc/Hz, or better, for carrier offset frequencies greater than 10 kHz, and a system flicker phase noise floor of -150 dBc/Hz, or better, at 1 Hz carrier offset. The paper discusses the results of detailed residual phase noise measurements performed on a number of components using this overall system configuration. Several interesting observations related to the residual phase noise properties of moderate to high power RF amplifiers, i.e., amplifiers with 1 dB gain compression points in the range of +20 to +33 dBm, are highlighted     

Animal model for the study of methanol toxicity: comparison of folate-reduced rat responses with published monkey data

The postpartum period is an ideal time to begin contraception, as women are more highly motivated to adopt contraception at this time and it is convenient for both patients and service providers. For intrauterine device (IUD) contraception, this period offers other advantages, such as ease of insertion and minimal adverse impacts on breastfeeding. Among early studies, most postpartum insertions were performed anywhere from a few hours to seven days or more after delivery, and retention of the IUD in the uterus was poor. Since the 1970s, immediate postplacental insertion (IPPI), i.e., IUD insertion performed within 10 minutes after placental delivery, has been advocated, and fairly, low expulsion rates have been reported. Up to now, IPPI has not been widely accepted in clinics because its expulsion rate still appears to be higher than that of interval insertion. In order to further study IPPI and perfect this contraceptive technique, it is essential to comprehensively review IPPI results and compare the Chinese experience with that of the rest of the world.     

Substance P modulates NMDA responses and causes long-term protein synthesis-dependent modulation of the lamprey locomotor network

Tachykinin immunoreactivity is found in a ventromedial spinal plexus in the lamprey. Neurons in this plexus project bilaterally and are thus in a position to modulate locomotor networks on both sides of the spinal cord. We have examined the effects of the tachykinin substance P on NMDA-evoked locomotor activity. Brief (10 min) application of tachykinin neuropeptides results in a prolonged concentration-dependent (>24 hr) modulation of locomotor activity, shown by the increased burst frequency and more regular burst activity. These effects are blocked by the tachykinin antagonist spantide II. There are at least two phases to the burst frequency modulation. An initial phase (approximately 2 hr) is associated with the protein kinase C-dependent potentiation of cellular responses to NMDA. The long-lasting phase (>2 hr) appears to be protein synthesis-dependent, with protein synthesis inhibitors causing the increased burst frequency to recover after washing for 2-3 hr. The modulation of the burst regularity is caused by a separate effect of tachykinins, because unlike the burst frequency modulation it does not require the modulation of NMDA receptors for its induction and is blocked by H8, an inhibitor of cAMP- and cGMP-dependent protein kinases. The effects of substance P were mimicked by the dopamine D2 receptor antagonist eticlopride. The effects of eticlopride were blocked by the tachykinin antagonist spantide II, suggesting that eticlopride may endogenously release tachykinins. Because locomotor activity in vitro corresponds to that during swimming in intact animals, we suggest that endogenously released tachykinins will result in prolonged modulation of locomotor behavior.     

Transient thermal performance of line traps

This paper develops a transient thermal model for line traps. The model was incorporated into a computer program that numerically integrates the governing nonlinear differential equation in time to predict critical temperatures and component short and long term ratings for a wide range of operating conditions. The model accounts for many factors including: variable air properties, variable material properties, environmental conditions, and a wide variety of component geometries and orientations. To verify the temperatures predicted by the thermal model, The Georgia Power Research Center carried out an extensive series of indoor laboratory tests to experimentally measure temperatures of energized line traps under transient loading conditions. Model predictions were within 8°C for 75 percent of the data. This paper presents the development of the governing equations and describes in detail the calculation of the convective and radiative components of heat transfer. Comparisons of the model predictions for two different line trap designs in different orientations to experimental data are presented to demonstrate the accuracy and flexibility of the thermal model