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排序方式: 共有802条查询结果,搜索用时 15 毫秒
21.
RS Bagley TV Baszler ML Harrington GE Pluhar MP Moore RD Keegan SA Greene 《Canadian Metallurgical Quarterly》1995,24(2):122-127
Longitudinal division of the corpus callosum was performed in six normal beagles to determine surgical morbidity. The corpus callosum was divided sagittally on the midline and the effect on neurological function was determined. Five of six dogs were clinically normal within 14 days or less after surgery. One dog had persistent but improving clinical signs consistent with a forebrain disturbance at 30 days after surgery. Overall, minimal morbidity and no mortality was associated with this surgical procedure. Further study is indicated to determine the efficacy of this surgical treatment for seizure control in dogs with idiopathic epilepsy. 相似文献
22.
Influence of the prenatal hypoinsulinaemia (streptozocin diabetes) on the behaviour of the offsprings of Wistar rats was studied from 1 to 20 postnatal days. In experimental pups there were slower weight increment, later eye opening, later development of elementary behavioural acts (grooming elements, rearing, sniffing), and later formation of complex behavioural patterns (investigation of an environment) than in the control offsprings of healthy females. 相似文献
23.
Svetlana V. Klinova Boris A. Katsnelson Ilzira A. Minigalieva Oksana P. Gerzen Alexander A. Balakin Ruslan V. Lisin Ksenia A. Butova Salavat R. Nabiev Oleg N. Lookin Leonid B. Katsnelson Larisa I. Privalova Daniil A. Kuznetsov Vladimir Ya. Shur Ekaterina V. Shishkina Oleg H. Makeev Irene E. Valamina Vladimir G. Panov Marina P. Sutunkova Larisa V. Nikitina Yuri L. Protsenko 《International journal of molecular sciences》2021,22(7)
Subchronic intoxication was induced in outbred male rats by repeated intraperitoneal injections with lead oxide (PbO) and/or cadmium oxide (CdO) nanoparticles (NPs) 3 times a week during 6 weeks for the purpose of examining its effects on the contractile characteristics of isolated right ventricle trabeculae and papillary muscles in isometric and afterload contractions. Isolated and combined intoxication with these NPs was observed to reduce the mechanical work produced by both types of myocardial preparation. Using the in vitro motility assay, we showed that the sliding velocity of regulated thin filaments drops under both isolated and combined intoxication with CdO–NP and PbO–NP. These results correlate with a shift in the expression of myosin heavy chain (MHC) isoforms towards slowly cycling β–MHC. The type of CdO–NP + PbO–NP combined cardiotoxicity depends on the effect of the toxic impact, the extent of this effect, the ratio of toxicant doses, and the degree of stretching of cardiomyocytes and muscle type studied. Some indices of combined Pb–NP and CdO–NP cardiotoxicity and general toxicity (genotoxicity included) became fully or partly normalized if intoxication developed against background administration of a bioprotective complex. 相似文献
24.
Diana Salikhova Tatiana Bukharova Elvira Cherkashova Daria Namestnikova Georgy Leonov Maria Nikitina Ilya Gubskiy Gevorg Akopyan Andrey Elchaninov Konstantin Midiber Natalia Bulatenco Victoria Mokrousova Andrey Makarov Konstantin Yarygin Vladimir Chekhonin Liudmila Mikhaleva Timur Fatkhudinov Dmitry Goldshtein 《International journal of molecular sciences》2021,22(9)
Transplantation of various types of stem cells as a possible therapy for stroke has been tested for years, and the results are promising. Recent investigations have shown that the administration of the conditioned media obtained after stem cell cultivation can also be effective in the therapy of the central nervous system pathology (hypothesis of their paracrine action). The aim of this study was to evaluate the therapeutic effects of the conditioned medium of hiPSC-derived glial and neuronal progenitor cells in the rat middle cerebral artery occlusion model of the ischemic stroke. Secretory activity of the cultured neuronal and glial progenitor cells was evaluated by proteomic and immunosorbent-based approaches. Therapeutic effects were assessed by overall survival, neurologic deficit and infarct volume dynamics, as well as by the end-point values of the apoptosis- and inflammation-related gene expression levels, the extent of microglia/macrophage infiltration and the numbers of formed blood vessels in the affected area of the brain. As a result, 31% of the protein species discovered in glial progenitor cells-conditioned medium and 45% in neuronal progenitor cells-conditioned medium were cell type specific. The glial progenitor cell-conditioned media showed a higher content of neurotrophins (BDNF, GDNF, CNTF and NGF). We showed that intra-arterial administration of glial progenitor cells-conditioned medium promoted a faster decrease in neurological deficit compared to the control group, reduced microglia/macrophage infiltration, reduced expression of pro-apoptotic gene Bax and pro-inflammatory cytokine gene Tnf, increased expression of anti-inflammatory cytokine genes (Il4, Il10, Il13) and promoted the formation of blood vessels within the damaged area. None of these effects were exerted by the neuronal progenitor cell-conditioned media. The results indicate pronounced cytoprotective, anti-inflammatory and angiogenic properties of soluble factors secreted by glial progenitor cells. 相似文献
25.
26.
The studies conducted show that: the efficiency of modification of as-spun PAN fibre is higher than with modification of the conditioned fibre; the fibres obtained can be recommended for fabrication of fire-resistant fabrics for work clothing. 相似文献
27.
L. G. Baikova Yu. K. Fedorov V. P. Pukh L. V. Tikhonova T. P. Kazannikova A. B. Sinani S. I. Nikitina 《Glass Physics and Chemistry》2004,30(5):420-424
The possibility of improving the mechanical properties of potassium aluminum metaphosphate glasses through the introduction of silicon oxide into the glass composition is analyzed. It is shown that the elastic moduli (Young modulus, shear modulus, Poisson ratio) and the hardness remain almost unchanged with an increase in the content of silicon oxide in the glass. At the same time, the structural strength increases by a factor of 1.7 and the fracture toughness increases by a factor of 1.3. The assumption is made that the observed increase in the structural strength is associated with the incorporation of silicon ions into the structure of the metaphosphate glass in the octahedral coordination. 相似文献
28.
V.?I.?Erofeev A.?V.?IlyahinskiiEmail author E.?A.?Nikitina V.?M.?Rodyushkin 《Russian Journal of Nondestructive Testing》2018,54(2):92-95
As exemplified by the use of different approaches to processing the results of probing metals with elastic waves, means have been studied for increasing the sensitivity of the ultrasonic method. Representing processes that determine the effect that a medium has on the parameters of an elastic wave by a statistical model in the form of a Dirichlet distribution makes it possible to numerically characterize changes in the structure of a probing pulse and to improve the understanding of phenomena that occur when an elastic wave interacts with a medium, with the degree of material damage taken into account. 相似文献
29.
Effect of vanadium and chromium on the microstructural features of V–Cr–Mn–Ni spheroidal carbide cast irons 总被引:2,自引:0,他引:2
V.G.Efremenko ;K.Shimizu ;A.P.Cheiliakh ;T.V.Kozarevskaya ;K.Kusumoto ;K.Yamamoto 《北京科技大学学报(英文版)》2014,(11):1096-1108
The objective of this investigation is to study the influence of vanadium(5.0wt%–10.0wt%) and chromium(0–9.0wt%) on the microstructure and hardness of Cr-V-Mn-Ni white cast irons with spheroidal vanadium carbides. The alloys' microstructural features are presented and discussed with regard to the distribution of phase elements. The structural constituents of the alloys are spheroidal VC, proeutectoid cementite, ledeburite eutectic, rosette-shaped carbide eutectic(based on M7C3), pearlite, martensite, and austenite. Their combinations and area fraction(AF) ratios are reported to be influenced by the alloys' chemical composition. Spheroidized VC particles are found to be sites for the nucleation of carbide eutectics. Cr and V are shown to substitute each other in the VC and M7C3 carbides, respectively. Chromium alloying leads to the formation of a eutectic(γ-Fe + М7С3), preventing the appearance of proeutectoid cementite in the structure. Vanadium and chromium are revealed to increase the total carbide fraction and the amount of austenite in the matrix. Cr is observed to play a key role in controlling the metallic matrix microstructure. 相似文献
30.