安装漏洞补丁鲁大师给微软系统也升级

2009年12月9日,微软向全球Windows用户发布12月份系统安全公告,本次漏洞修复共4个补丁,其中3个补丁针对微软Windows系统。1个补丁针对微软的Office办公软件。都隶属于“严重”和“重要”的安全级别,建议广大用户立即更新,以保证电脑应用的安全性。     

Windows7资源管理器失忆操作技巧

不同的优化技巧和系统设置技巧,对不同的人有着不同的用处,很多人苦心想解决的问题可能对有些朋友压根没用。例如隐私保护,很多朋友电脑就一人用,很少考虑此类问题。     

Social network,social trust and shared goals in organizational knowledge sharing

The aim of our study was to further develop an understanding of social capital in organizational-knowledge-sharing. We first developed a measurement tool and then a theoretical framework in which three social capital factors (social network, social trust, and shared goals) were combined with the theory of reasoned action; their relationships were then examined using confirmatory factoring analysis. We then surveyed of 190 managers from Hong Kong firms, we confirm that a social network and shared goals significantly contributed to a person's volition to share knowledge, and directly contributed to the perceived social pressure of the organization. The social trust has however showed no direct effect on the attitude and subjective norm of sharing knowledge.     

搜狗浏览器1.4正式版评测

说到目前上网速度最快的浏览器,搜狗浏览器的名字一定会被提及。凭借着＂全网加速＂和＂多任务异步浏览＂这两项业内首创的技术,搜狗浏览器一举成为上网最流畅的浏览器之一。而近日,搜狗浏览器又推出了1.4正式版。新加入了网络收藏夹、Windows7新特性完美支持等功能。笔者有幸在第一时间对这款软件进行深度评测。     

Activating a zymogen without proteolytic processing: mutation of Lys15 and Asn194 activates trypsinogen

The zymogen and mature enzyme forms of trypsin-like serine proteases exhibit a wide range of activities. The prototypical trypsinogen-trypsin system is an example of a minimally active zymogen and a maximally active mature protease. The present work identifies several features of trypsinogen which govern its activity. Our results indicate that rat trypsin is 10(8)-fold more active than rat trypsinogen. Rat trypsinogen appears to be less active than bovine trypsinogen. His40 is believed to be an important determinant of zymogen activity. We are unable to verify this role for His40 in trypsinogen since the mutation of His40 to Phe appears to change the trypsin-substrate interface. Deletion of the N-terminal Ile16 from trypsin is expected to produce a trypsinogen-like protein since the Ile16-Asp194 salt bridge cannot form. Such mutants have higher activity and BPTI affinity than trypsinogen, which indicates that the activation peptide stabilizes the inactive trypsinogen conformation. The mutation of Lys15 to Ala increases the BPTI affinity and activity of trypsinogen to an even greater extent; thus, removal of Lys15 can account for the effect of the loss of the activation peptide. These results suggest that Lys15 is an important determinant of zymogen activity. The mutation of Asp194 to Asn also increases the BPTI affinity and activity of trypsinogen. This result suggests that in addition to stabilizing the active conformation of trypsin via the Ile16-Asp194 salt bridge, Asp194 also maintains the inactive conformation of trypsinogen. A correlation exists between the values of kcat/Km and BPTI affinity of mutant trypsinogens and trypsins. However, the slope of this correlation is 0.64, which indicates that different "active" conformations are involved in BPTI binding and substrate hydrolysis. DeltaI16V17 trypsinogen is the lone outlier; its BPTI affinity is higher than would be expected based on the value of kcat/Km. We show that the rate of BPTI association is slower for DeltaI16V17 trypsinogen than for a mutant trypsinogen with a similar BPTI affinity. This observation suggests that BPTI binds to an "active" trypsinogen conformation that is not kinetically accessible to substrates.     

Preparation of nanometre size oxide particles using filter expansion aerosol generator

Crystalline zinc oxide particles of nanometre size (< 20 nm) particles were produced from a zinc acetate solution by using a filter expansion aerosol generator (FEAG). The FEAG is an aerosol generator that is operated at 60 torr reactor pressure and produces droplets of around 2 m. The shape of the particles produced by the FEAG were distinctively different from those produced by the ultrasonic spray source (USS). Results from scanning electron microscopy (SEM) and X-ray diffractometry (XRD) indicated that crystalline zinc oxide particles of nanometre size were produced at 600 °C in 0.02 s residence time. Weight loss of these particles, determined by thermogravimetric analysis (TGA), was 3 wt%. Based on the morphology change as a function of the reactor temperature and solute concentration, we proposed that the nanometre particles were formed by uniform precipitation at the drying stage and decomposition followed by disintegration into nanometre particles. It was also shown that exothermic decomposition of the solute was not required for the disintegration of the primary particles in the FEAG process. This result opened up an opportunity for producing carbon-free nanometre particles from nitrate salts by using the FEAG.     

Utility function of TCP

Understanding the TCP congestion control mechanism from a global optimization point of view is not only important in its own right, but also crucial to the design of other transport layer traffic control protocols with provable properties. In this paper, we derive a global utility function and the corresponding optimal control law, known as TCP control law, which maximizes the global utility. The TCP control law captures the essential behaviors of TCP, including slow start, congestion avoidance, and the binary nature of congestion feedback in TCP. We find that the utility function of TCP is linear in the slow start phase and is proportional to the additive increase rate and approaches the well-known logarithm function as the data rate becomes large in the congestion avoidance phase. We also find that understanding the slow start phase with a fixed threshold is critical to the design of new transport layer control protocols to enable quality of service features. Finally, as an application, we design a Minimum Rate Guaranteed (MRG) traffic control law that shares the same utility function as the TCP control law. Our simulation study of the MRG control law indicates that it is indeed TCP friendly and can provide minimum rate guarantee as long as the percentage of network resource consumed by the MRG flows is moderately small.     

P(VDF-TrFE) copolymer acoustic emission sensors

Acoustic emission (AE) sensors have been fabricated using polarized polyvinylidene fluoride/trifluoroethylene (P(VDF-TrFE)) piezoelectric copolymer films. The acoustic and electromechanical properties of the copolymers have been determined using the ultrasonic immersion technique and the resonance technique, respectively. The P(VDF-TrFE) AE sensors have been calibrated according to the ASTM standard and evaluated for potential application in the detection of AE in glass fiber reinforced polypropylene (GFPP). A ceramic AE sensor also has been fabricated using lead zirconate titanate (PZT) 7A piezoelectric ceramic and its sensitivity and performance are reported as well. The copolymer sensors do not show resonance peaks of the ceramic sensor and have adequate sensitivity. They can reproduce AE signals accurately without giving artifacts and have potential use in commercial AE systems.     

高校学生诚信教育体系构建

随着我国社会经济的进一步转型,如何更有效地进行诚信教育已成为高校德育教育的一项重要课题。本文从诚信的内涵出发,以大学生诚信现状为切入点,并在此基础上对大学生诚信缺失的现象和存在的问题进行深入分析,提出构建高校学生诚信体系的对策或建议。     

Evaluation of a Computer-Assisted, 2-D Virtual Reality System for Training People With Intellectual Disabilities on How to Shop.

Objective: To evaluate the effectiveness of a 2-D virtual reality (VR) program for training people with intellectual disabilities to shop. Study Design: Pretest and posttest quasi-experimental design. Participants: Sixteen persons with intellectual disabilities (age 17-23 years; IQ = 40-54). Intervention: A VR program or a conventional program training them in supermarket-shopping skills. Main Outcome Measure: Checklist for supermarket-shopping skills. Results: Participants in both training groups showed significant improvement. There was no significant difference in effectiveness between the two methods. Conclusions: The VR program appears effective in training people with intellectual disabilities in an important community living skill. (PsycINFO Database Record (c) 2010 APA, all rights reserved)