Fatty acid profile and affective dysregulation in irritable bowel syndrome

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with a high co-occurrence with affective dysregulation. Affective disorders have been associated with specific changes in the PUFA and cholesterol profile. In IBS, similar changes may be present as have been reported in patients with affective disorders. This exploratory study investigates (i) the level of affective dysregulation (AD) in IBS patients and healthy controls; (ii) PUFA and cholesterol profiles in IBS patients compared with controls; and (iii) associations between PUFA and cholesterol parameters with the level of AD. Blood samples were obtained for determination of the FA composition of plasma phospholipids and serum cholesterol in 23 diarrheapredominant IBS patients and 23 healthy matched controls. AD was scored using the Symptom Check List depression scale, the Hospital Anxiety and Depression Scale, and the Hamilton Depression Rating Scale. The level of AD was higher in IBS patients compared with controls. PUFA and cholesterol profiles did not differ significantly between groups. Total n−3 PUFA and cholesterol were significantly negatively associated and the ratio of n−6 to n−3 PUFA and the ratio of arachidonic acid to EPA were significantly positively associated with the level of AD. The findings of the present study reveal that AD was higher in IBS patients compared with healthy controls and that changes in PUFA and cholesterol profiles were significantly associated with the level of AD. These results warrant further studies regarding the role of PUFA and cholesterol status in the co-occurrence of AD and functional gastrointestinal disorders.     

Programming by Demonstration Using Version Space Algebra

Programming by demonstration enables users to easily personalize their applications, automating repetitive tasks simply by executing a few examples. We formalize programming by demonstration as a machine learning problem: given the changes in the application state that result from the user's demonstrated actions, learn the general program that maps from one application state to the next. We present a methodology for learning in this space of complex functions. First we extend version spaces to learn arbitrary functions, not just concepts. Then we introduce the version space algebra, a method for composing simpler version spaces to construct more complex spaces. Finally, we apply our version space algebra to the text-editing domain and describe an implemented system called SMARTedit that learns repetitive text-editing procedures by example. We evaluate our approach by measuring the number of examples required for the system to learn a procedure thatworks on the remainder of examples, and by an informal user study measuring the effort users spend using our system versus performing the task by hand. The results show that SMARTedit is capable of generalizing correctly from as few as one or two examples, and that users generally save a significant amount of effort when completing tasks with SMARTedit's help.     

The influence of linguistic experience on the cognitive processing of pitch in speech and nonspeech sounds.

In the present experiment, the authors tested Mandarin and English listeners on a range of auditory tasks to investigate whether long-term linguistic experience influences the cognitive processing of nonspeech sounds. As expected, Mandarin listeners identified Mandarin tones significantly more accurately than English listeners; however, performance did not differ across the listener groups on a pitch discrimination task requiring fine-grained discrimination of simple nonspeech sounds. The crucial finding was that cross-language differences emerged on a nonspeech pitch contour identification task: The Mandarin listeners more often misidentified flat and falling pitch contours than the English listeners in a manner that could be related to specific features of the sound structure of Mandarin, which suggests that the effect of linguistic experience extends to nonspeech processing under certain stimulus and task conditions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Parafoveal preview during reading: Effects of sentence position.

Two experiments examined parafoveal preview for words located in the middle of sentences and at sentence boundaries. Parafoveal processing was shown to occur for words at sentence-initial, mid-sentence, and sentence-final positions. Both Experiments 1 and 2 showed reduced effects of preview on regressions out for sentence-initial words. In addition, Experiment 2 showed reduced preview effects on first-pass reading times for sentence-initial words. These effects of sentence position on preview could result from either reduced parafoveal processing for sentence-initial words or other processes specific to word reading at sentence boundaries. In addition to the effects of preview, the experiments also demonstrate variability in the effects of sentence wrap-up on different reading measures, indicating that the presence and time course of wrap-up effects may be modulated by text-specific factors. We also report simulations of Experiment 2 using version 10 of E-Z Reader (Reichle, Warren, & McConnell, 2009), designed to explore the possible mechanisms underlying parafoveal preview at sentence boundaries. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Uncovering sexuality and gender: an intersectional examination of women’s experience in UK construction

UK employers have been broadening their equality and diversity activities to include the issue of sexual orientation; however, the construction industry has been slow to follow. Equally there is a lack of research on the experiences of lesbian, gay, bisexual and transgender (LGBT) workers in construction. While women’s sexuality soon becomes a focus of interest when they enter male-dominated work, little research has discussed how sexual minorities–and in particular lesbians–fare in such environments. This article examines how both gender and sexuality interact to shape women’s working lives within the UK construction sector, drawing on 22 interviews and a focus group with heterosexual women and lesbians in male-dominated occupations in construction. While women share common experiences of heightened interest and questioning, open lesbians can sometimes minimize the sexualized content of workplace interactions. However the potential for exclusion on the basis of minority sexuality also exists. Sexual harassment appears less prevalent for women in professional occupations than in the past, while women in the manual trades reported that the problem persists. Lesbians can experience different forms of harassment, however, from heterosexual women, while employers are less developed in their response to homophobic harassment.     

Printed electronic switch on flexible substrates using printed microcapsules

Printed electronics, the manufacturing of electronic components on large, flexible, and low-cost substrates by printing techniques, can facilitate widespread, very low-cost electronics for consumer applications and disposable devices. New technologies are needed to create functional components in this field. This paper introduces a new method to create an all-additive printed switch on flexible substrate materials, such as polymer foils and paper substrates. The active layer of the switch component consists of neutral polyaniline (PANI), which can be doped by acid to induce a shift from a non-conductive to a conductive oxidation state. Monodisperse core–shell microcapsules containing an acidic aqueous core liquid were produced by a novel inkjet-based encapsulation technology. It was shown that unfavorable water evaporation from the microcapsules could be reduced by the addition of calcium chloride to the core liquid. A switch component was prepared, consisting of inkjet-printed interdigitated silver electrodes, PANI active layer and printed microcapsules. If an external pressure was applied, for instance with a finger, then the switch component changed its state from non-conductive to conductive with a simultaneous distinct color change. The results clearly demonstrate the feasibility of the presented approach to create either a visual or electronic signal for use in printed electronic applications.     

The significance of event information for 6- to 16-month-old infants' perception of containment.

Four experiments familiarized 6-, 9-, 12-, and 16-month-old infants to a solid block that was repeatedly lowered into a semitransparent container. In test trials the end state, containment, was either compatible or incompatible with the objects' size and position. In Experiment 1, infants saw the block and box successively before they observed the end state. This forced infants to attend to each object individually and memorize its size and position while observing the end state. In Experiments 2 and 3, the block and container were shown simultaneously, the block suspended above the container at a distance of either 25 cm (Experiment 2) or 2 cm (Experiment 3). The shorter distance made direct comparison easier to perform. In Experiment 4, the full event was shown in which the block was lowered inside the container from a distance of 25 cm. Infants' perception of containment was related to the visual information that was available. When the event made it easier to grasp the relevant information, infants could perceive whether the block could pass in the container at a progressively younger age. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Biocompatible Azide–Alkyne “Click” Reactions for Surface Decoration of Glyco‐Engineered Cells

Bio‐orthogonal copper (I)‐catalyzed azide–alkyne cycloaddition (CuAAC) has been widely used to modify azide‐ or alkyne‐bearing monosaccharides on metabolic glyco‐engineered mammalian cells. Here, we present a systematic study to elucidate the design space for the cytotoxic effects of the copper catalyst on NIH 3T3 fibroblasts and on HEK 293‐F cells. Monitoring membrane integrity by flow cytometry and RT‐PCR analysis with apoptotic and anti‐apoptotic markers elucidated the general feasibility of CuAAC, with exposure time of the CuAAC reaction mixture having the major influence on biocompatibility. A high labeling efficiency of HEK 293‐F cells with a fluorescent alkyne dye was rapidly achieved by CuAAC in comparison to copper free strain‐promoted azide–alkyne cycloaddition (SPAAC). The study details effective and biocompatible conditions for CuAAC‐based modification of glyco‐engineered cells in comparison to its copper free alternative.     

Kernel density estimation and K-means clustering to profile road accident hotspots

Identifying road accident hotspots is a key role in determining effective strategies for the reduction of high density areas of accidents. This paper presents (1) a methodology using Geographical Information Systems (GIS) and Kernel Density Estimation to study the spatial patterns of injury related road accidents in London, UK and (2) a clustering methodology using environmental data and results from the first section in order to create a classification of road accident hotspots. The use of this methodology will be illustrated using the London area in the UK. Road accident data collected by the Metropolitan Police from 1999 to 2003 was used. A kernel density estimation map was created and subsequently disaggregated by cell density to create a basic spatial unit of an accident hotspot. Appended environmental data was then added to the hotspot cells and using K-means clustering, an outcome of similar hotspots was deciphered. Five groups and 15 clusters were created based on collision and attribute data. These clusters are discussed and evaluated according to their robustness and potential uses in road safety campaigning.