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21.
Mamballykalathil N. Menon Ho T. Fang David C. Wu Michael G. Jenkins Mattison K. Ferber Karren L. More Camden R. Hubbard Theodore A. Nolan 《Journal of the American Ceramic Society》1994,77(5):1217-1227
Cylindrical buttuohead specimens of an advanced silicon nitride were tested in uniaxial tension at temperatures between 1422 and 1673 K. In the range 1477 to 1673 K, creep deformation was reliably measured using high-temperature contact probe extensometry. Extensive scanning and transmission electron microscopy has revealed the formation of lenticular cavities at two-grain junctions at all temperatures (1422–1673 K) and extensive triple-junction cavitation occurring at the higher temperatures (1644–1673 K). Cavitation is believed to be part of the net creep process. The stress rupture data show stratification of the Monkman–Grant lines with respect to temperature. Failure strain increased with increase in rupture time or temperature, or decrease in stress. Fractography showed that final failure occurred by subcritical crack growth in all specimens. 相似文献
22.
Charles E. Carraher Jr. Theodore S. Sabir Michael R. Roner Kimberely Shahi Robert E. Bleicher Joanne L. Roehr Kelly D. Bassett 《Journal of Inorganic and Organometallic Polymers and Materials》2006,16(3):249-257
Organotin polyamine ethers containing acyclovir in their backbone were synthesized in moderate to high yield employing the aqueous interfacial polycondensation system. The products are high molecular weight polymers. Infrared spectroscopy of the products shows new bands characteristic of the formation of Sn–N and Sn–O bonds consistent with the proposed structure. MALDI-TOF MS below 2000 Da shows the presence of organotin and acyclovir units containing these two moieties. The products show moderate inhibition of a number of cancer cell lines and exhibit the ability to inhibit a number of viruses, particularly the herpes simplex virus-1 and varicella zoster virus that are responsible for herpes, chicken pox and shingles. 相似文献
23.
Stephen Scypinski Linda Nelson Theodore Sadlowski 《Journal of Automated Methods and Management in Chemistry》1995,17(2):47-49
It has been over 10 years since robots have appeared in the pharmaceutical analysis laboratory. In the early days, it was common for one selected individual to be responsible for the programming, usage and maintenance of the robots(s). However, the increasing use of robotics has prompted the formation of robotics
‘laboratories’ and/or ‘groups’. This is especially true when
multiple robotic systems and applications are involved.Over the past several years at ISLAR, many champions of robotics have given presentations on the setup and usage of robotics within their organizations. These managers have described both the ‘centralized’ and ‘decentralized’ approaches to the implementation of robotics. In the centralized system, a single group is charged with all aspects of the robotic project, including justification, purchase, validation, use and maintenance. Under such an
arrangement, samples are usually given to the robotics group for analysis. In contrast, a totally decentralized approach to robotics would have units interspersed throughout the organization, with each individual group responsible for their respective unit(s), in
much the same way as liquid chromatographs are considered.At Hoffmann-La Roche, aspects of both the centralized and decentralized approaches to robotics are used which make our combined system the ‘best of both worlds’. This paper describes the Roche philosophy towards robotics and highlights the advantages to the system used. 相似文献
24.
Garrett BC Dixon DA Camaioni DM Chipman DM Johnson MA Jonah CD Kimmel GA Miller JH Rescigno TN Rossky PJ Xantheas SS Colson SD Laufer AH Ray D Barbara PF Bartels DM Becker KH Bowen KH Bradforth SE Carmichael I Coe JV Corrales LR Cowin JP Dupuis M Eisenthal KB Franz JA Gutowski MS Jordan KD Kay BD Laverne JA Lymar SV Madey TE McCurdy CW Meisel D Mukamel S Nilsson AR Orlando TM Petrik NG Pimblott SM Rustad JR Schenter GK Singer SJ Tokmakoff A Wang LS Wettig C Zwier TS 《Chemical reviews》2005,105(1):355-390
25.
Florina M. Ciorba Ioannis Riakiotakis Theodore Andronikos George Papakonstantinou Anthony T. Chronopoulos 《Journal of Parallel and Distributed Computing》2008
Existing dynamic self-scheduling algorithms, used to schedule independent tasks on heterogeneous clusters, cannot handle tasks with dependencies because they lack the support for internode communication. To compensate for this deficiency we introduce a synchronization mechanism that provides inter-processor communication, thus, enabling self-scheduling algorithms to handle efficiently nested loops with dependencies. We also present a weighting mechanism that significantly improves the performance of dynamic self-scheduling algorithms. These algorithms divide the total number of tasks into chunks and assign them to processors. The weighting mechanism adapts the chunk sizes to the computing power and current run-queue state of the processors. The synchronization and weighting mechanisms are orthogonal, in the sense that they can simultaneously be applied to loops with dependencies. Thus, they broaden the application spectrum of dynamic self-scheduling algorithms and improve their performance. Extensive testing confirms the efficiency of the synchronization and weighting mechanisms and the significant improvement of the synchronized–weighted versions of the algorithms over the synchronized-only versions. 相似文献
26.
Theodore Pachidis John Lygouras Kostas Tarchanidis 《Journal of Intelligent and Robotic Systems》2008,51(4):385-420
In this paper, first HumanPT architecture for low cost robotic applications is presented. HumanPT architecture differs than
other architectures because it is implemented on existing robotic systems (robot robotic controller) and exploits the minimum
communication facilities for real-time control that these systems provide. It is based on well-known communication methods
like serial communication (USB, RS232, IEEE-1394) and windows sockets (server–client model) and permits an important number
of different type of components like actuators, sensors and particularly vision systems to be connected in a robotic system.
The operating system (OS) used is Microsoft Windows, the most widely spread OS. The proposed architecture exploits features
of this OS that is not a real-time one, to ensure – in case that the robotic system provide such a facility – control and
real time communication with the robotic system controller and to integrate by means of sensors and actuators an important
number of robotic tasks and procedures. As implementation of this architecture, HumanPT robotic application and experimental results concerning its performance and its implementation in real tasks are provided.
HumanPT robotic application, developed in Visual C++, is an integrated, but simultaneously an open-source software that can be adapted
in different types of robotic systems. An important number of robotic tasks or procedures including sensors and particularly
vision systems can be generated and executed. Small enterprises by means of the proposed architecture and the open source
software can be automated at low cost enhancing in this way their production. 相似文献
27.
28.
Xiaoying Wu Dimitri Theodoratos Stefanos Souldatos Theodore Dalamagas Timos Sellis 《World Wide Web》2010,13(4):441-474
Finding the occurrences of structural patterns in XML data is a key operation in XML query processing. Existing algorithms
for this operation focus almost exclusively on path patterns or tree patterns. Current applications of XML require querying
of data whose structure is complex or is not fully known to the user, or integrating XML data sources with different structures.
These applications have motivated recently the introduction of query languages that allow a partial specification of path
patterns in a query. In this paper, we consider partial path queries, a generalization of path pattern queries, and we focus
on their efficient evaluation under the indexed streaming evaluation model. Our approach explicitly deals with repeated labels
(that is, multiple occurrences of the same label in a query). We show that partial path queries can be represented as rooted
dags for which a topological ordering of the nodes exists. We present three algorithms for the efficient evaluation of these
queries. The first one exploits a structural summary of data to generate a set of path patterns that together are equivalent
to a partial path query. To evaluate these path patterns, we extend a previous algorithm for path-pattern queries so that
it can work on path patterns with repeated labels. The second one extracts a spanning tree from the query dag, uses a stack-based
algorithm to find the matches of the root-to-leaf paths in the tree, and merge-joins the matches to compute the answer. Finally,
the third one exploits multiple pointers of stack entries and a topological ordering of the query dag to apply a stack-based
holistic technique. We analyze our algorithms and perform extensive experimental evaluations. Our experimental results show
that the holistic algorithm outperforms the other ones. Our approaches are the first ones to efficiently evaluate this class
of queries in the indexed streaming model. 相似文献
29.
Joshi A Qian X Dione DP Bulsara KR Breuer CK Sinusas AJ Papademetris X 《IEEE transactions on visualization and computer graphics》2008,14(6):1603-1610
The effective visualization of vascular structures is critical for diagnosis, surgical planning as well as treatment evaluation. In recent work, we have developed an algorithm for vessel detection that examines the intensity profile around each voxel in an angiographic image and determines the likelihood that any given voxel belongs to a vessel; we term this the "vesselness coefficient" of the voxel. Our results show that our algorithm works particularly well for visualizing branch points in vessels. Compared to standard Hessian based techniques, which are fine-tuned to identify long cylindrical structures, our technique identifies branches and connections with other vessels. Using our computed vesselness coefficient, we explore a set of techniques for visualizing vasculature. Visualizing vessels is particularly challenging because not only is their position in space important for clinicians but it is also important to be able to resolve their spatial relationship. We applied visualization techniques that provide shape cues as well as depth cues to allow the viewer to differentiate between vessels that are closer from those that are farther. We use our computed vesselness coefficient to effectively visualize vasculature in both clinical neurovascular x-ray computed tomography based angiography images, as well as images from three different animal studies. We conducted a formal user evaluation of our visualization techniques with the help of radiologists, surgeons, and other expert users. Results indicate that experts preferred distance color blending and tone shading for conveying depth over standard visualization techniques. 相似文献
30.
Mantzourani ED Platts JA Brancale A Mavromoustakos TM Tselios TV 《Journal of molecular graphics & modelling》2007,26(2):471-481
This work reports molecular dynamics studies at the receptor level of the immunodominant myelin basic protein (MBP) epitope 87-99 implicated in multiple sclerosis, and its antagonists altered peptide ligands (APLs), namely [Arg91, Ala96] MBP87-99 and [Ala91,96] MBP87-99. The interaction of each peptide ligand with the receptor human leukocyte antigen HLA-DR2b was studied, starting from X-ray structure with pdb code: 1ymm. This is the first such study of APL-HLA-DR2b complexes, and hence the first attempt to gain a better understanding of the molecular recognition mechanisms that underlie TCR antagonism by these APLs. The amino acids His88 and Phe89 serve as T-cell receptor (TCR) anchors in the formation of the trimolecular complex TCR-peptide-HLA-DR2b, where the TCR binds in a diagonal, off-centered mode to the peptide-HLA complex. The present findings indicate that these two amino acids have a different orientation in the APLs [Arg91, Ala96] MBP87-99 and [Ala91,96] MBP87-99: His88 and Phe89 remain buried in HLA grooves and are not available for interaction with the TCR. We propose that this different topology could provide a possible mechanism of action for TCR antagonism. 相似文献