Indexing transitional knowledge.

Various indexes have been proposed to mark when a child is on the verge of acquiring new knowledge. This article described a new method for indexing this point of transition, which is based on the specificity of children's verbal explanations. The degree to which children were specific in their verbal explanations was related to whether they benefited from instruction. In particular, children who were vague in their explanations (i.e., less specific) benefited from instruction more than children who were explicit in their explanations (i.e., more specific). This index provides insights into the child's mental state prior to acquiring new knowledge. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Book reviews

RESOURCE TRENDS AND POPULATION POLICY: A TIME FOR REASSESSMENT, by Lester R. Brown. Worldwatch Institute, Washington, D.C., May 1979; Worldwatch Paper 29. (Paperback $2.00)

THE NEXT SEVENTY YEARS: POPULATION, FOOD AND RESOURCES, by B. Gil‐land. Abacus Press, London, 1979. 133 pp. (£9.50)

POPULATION POLICY ANALYSIS, edited by M. E. Kraft and M. Schneider. D. C. Heath, London, 1979. (£0.00)

ENVIRONMENTAL IMPACT ASSESSMENT, by Brian B. Clark, Ronald Bisset and Peter Wath‐ern. Manssell, London and Bowker, New York, 1980. 516 pp. (£0.00)

ADVANCES IN ECOLOGICAL RESEARCH, Vol. 11, edited by Amyan MacFadyen. Academic Press, London, 1980. 428 pp. (£25.00)

MICROBIAL GROWTH AND SURVIVAL IN EXTREMES OF ENVIRONMENT, edited by G. W. Gould and Janet E. Cory. Academic Press, London, 1980. 244 pp. (£16.00)

UNDER NEW MANAGEMENT: Port Growth and Emerging Coastal Management Programs, by Marc Hershman, Robert Goodwin, Andrew Ruot‐sala, Maureen McCrea and Yehuda Hayuth. A Washington Sea Grant Publication, 1978. 212 pp. ($12.50)

HANDBOOK OF INDUSTRIAL ENERGY ANALYSIS, by J. Boustead and G. F. Hancock. Ellis‐Harwood, Chichester, U.K., 1979. (£25.00)

TREE GROWTH AND ENVIRONMENTAL STRESSES, by T. T. Kozlowski. University of Washington Press, Seattle and London, 1979. vii + 192 pp. (£12.50)

ALL GOOD THINGS AROUND US, by Pamela Michael. Illustrated by Christabel King. Ernest Benn Ltd., London, 1980. 240 pp. (£12.95)

HUMAN GEOGRAPHY (2nd Edition), by A. V. Perpillou. Longman Group, London, U.K., 1977. xviii + 570 pp. 37 pls., 27 maps and diagrams, Index. (Paperback £5.50)

INDUSTRIAL AND HAZARDOUS WASTES IMPOUNDMENT, by N. P. Cheremisinoff, P. N. Cheremisinoff, F. Ellerbeck and A. J. Perna. Ann Arbor Science, Michigan, 1979. ix + 475 pp. Index. (£16.25)

PHOSPHORUS IN THE ENVIRONMENT: ITS CHEMISTRY AND BIOCHEMISTRY. (Ciba Foundation No. 57, New Series), by Ruth Porter and David W. Fitzsimons. Elsevier, 1978. (£18.15)

TOXIC AND HAZARDOUS WASTE DISPOSAL. Vol. II, edited by R. B. Pojasek (Options for Sterilization Solidifications). Ann Arbor Science, Michigan, U.S.A., 1979, 259 pp. (£19.80)

SON OF THE WILDERNESS (The Life of John Muir), by Linnie Marsh Wolfe. The University of Wisconsin Press, Madison, 1978. 364 pp. (Paperback £4.90)

NATURE'S PRICE, by W. van Dieren and M. G. W. Hummelinck. Marion Boyars, London, Boston, 1979. (Paperback £3.50)

PERMACULTURE ONE, by Bill (B. C.) Molli‐son and David Holmgren. Corgi Books, Trans‐world Publishers Ltd., Melbourne, Australia. 128 pp. (A $4.95)

ENVIRONMENTAL AERODYNAMICS, by R. S. Scorer. Ellis Horwood, Chichester, U.K., 1978. 488 pp. (Hardback £20.00; paperback £7.50)     

Sustainability: ecological, social, economic, technological, and systems perspectives

Sustainability is generally associated with a definition by the World Commission on Environment and Development, 1987: "... development that meets the needs of the present without compromising the ability of future generations to meet their own needs ..." However, there is no mathematical theory embodying these concepts, although one would be immensely valuable in humanity's efforts to manage the environment. The concept of sustainability applies to integrated systems comprising humans and the rest of nature; the structures and operation of the human component (society, economy, law, etc.) must be such that they reinforce the persistence of the structures and operation of the natural component (ecosystem trophic linkages, biodiversity, biogeochemical cycles, etc.). One of the challenges of sustainability research lies in linking measures of ecosystem functioning to the structure and operation of the associated social system. We review the nature of this complex system including its ecological, social, economic, and technological aspects, and propose an approach to assessing sustainability based on Information Theory that bridges the natural and human systems. These principles are then illustrated using a model system with an ecological food web linked to a rudimentary social system. This work is part of the efforts of a larger multidisciplinary group at the U.S. Environmental Protection Agency's National Risk Management Research Laboratory.     

Discovery of Affinity-Based Probes for Btk Occupancy Assays

Bruton's tyrosine kinase (Btk) is an attractive target for the treatment of a wide array of B-cell malignancies and autoimmune diseases. Small-molecule covalent irreversible Btk inhibitors targeting Cys481 have been developed for the treatment of such diseases. In clinical trials, probe molecules are required in occupancy studies to measure the level of engagement of the protein by these covalent irreversible inhibitors. The result of this pharmacodynamic (PD) activity provides guidance for appropriate dosage selection to optimize inhibition of the drug target and correlation of target inhibition with disease treatment efficacy. This information is crucial for successful evaluation of drug candidates in clinical trials. Based on the pyridine carboxamide scaffold of a novel solvent-accessible pocket (SAP) series of covalent irreversible Btk inhibitors, we successfully developed a potent and selective affinity-based biotinylated probe 12 (2-[(4-{4-[5-(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)pentanoyl]piperazine-1-carbonyl}phenyl)amino]-6-[1-(prop-2-enoyl)piperidin-4-yl]pyridine-3-carboxamide). Compound 12 has been used in Btk occupancy assays for preclinical studies to determine the therapeutic efficacy of Btk inhibition in two mouse lupus models driven by TLR7 activation and type I interferon.     

The structure of client language and drinking outcomes in project match.

Client language during Motivational Interviewing interventions is an important predictor of drinking outcomes, but there are inconsistencies in the literature regarding what aspects of client language are most predictive. We characterized the structure of client language by factor analyzing frequency counts of several categories of client speech. The results provide limited support for a model proposed by Miller et al. (2006) and Amrhein et al. (2003) but with some important differences. While Amrhein et al. (2003) found that only increasing strength in client commitment language predicted behavior change, the current study revealed that client language preparatory to commitment predicted drinking outcomes. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Removal of Metals and Acidity from Acid Mine Drainage Using Municipal Wastewater and Activated Sludge

Co-treatment of acid mine drainage (AMD) and municipal wastewater (MWW) using the activated sludge process is an innovative approach to AMD remediation that utilizes the alkalinity of MWW and the adsorptive properties of the wastewater particulates and activated sludge biomass to buffer acidity and remove metals. The capacity of these materials to treat AMD was investigated in batch mode metal removal tests using high-strength synthetic AMD (pH 2.8, Al 120–200 mg/L, Cu 18–30 mg/L, Fe 324–540 mg/L, Mn 18–30 mg/L, and Zn 36–60 mg/L). Using material from a range of MWW treatment plants, the performance of screened and settled MWW, activated sludges with mixed liquor suspended solids (MLSS) concentrations of 2.0 and 4.0 g/L, and return activated sludges with 6.0 and 7.4 g/L MLSS were compared. Similar trends were observed for the MWW and activated sludges, with removal efficiency generally decreasing in the order Al = Cu > Mn > Zn > Fe. Trends in Fe removal using settled MWW and activated sludges were highly variable, with removal <30 %. Using activated sludges, average removal efficiencies for Al, Cu, Mn, and Zn were 10–65 %, 20–60 %, 10–25 %, and 0–20 %, respectively. Sludge solids concentration was an important controlling factor in metal removal, with removal of Al, Cu, Mn, and Zn increasing significantly with solids concentration. Municipal wastewaters had greater neutralization capacities than activated sludges at high AMD loading ratios. Mixing AMD with screened MWW gave the highest removal efficiency for all metals, achieving average removal of 90–100 % for Al, Cu, and Fe, 65–100 % for Zn, and 60–75 % for Mn. These empirical findings are useful for developing process design parameters in co-treatment systems. Utilizing MWW and activated sludge to remediate AMD can potentially reduce materials and energy requirements and associated costs.     

Environmental contingency in life history strategies: The influence of mortality and socioeconomic status on reproductive timing.

Why do some people have children early, whereas others delay reproduction? By considering the trade-offs between using one's resources for reproduction versus other tasks, the evolutionary framework of life history theory predicts that reproductive timing should be influenced by mortality and resource scarcity. A series of experiments examined how mortality cues influenced the desire to have children sooner rather than later. The effects of mortality depended critically on whether people grew up in a relatively resource-scarce or resource-plentiful environment. For individuals growing up relatively poor, mortality cues produced a desire to reproduce sooner—to want children now, even at the cost of furthering one's education or career. Conversely, for individuals growing up relatively wealthy, mortality cues produced a desire to delay reproduction—to further one's education or career before starting a family. Overall, mortality cues appear to shift individuals into different life history strategies as a function of childhood socioeconomic status, suggesting important implications for how environmental factors can influence fertility and family size. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Minnesota Multiphasic Personality Inventory normal K+ and other unelevated profiles.

Compared empirical correlates of normal K+ and non-K+ unelevated Minnesota Multiphasic Personality Inventory (MMPI) profiles in a psychiatric inpatient setting. Case history (symptom ratings, demographic variables, and diagnoses) and psychometric data were obtained without knowledge of MMPI profile group membership from psychiatrists' discharge summaries on 84 male and female inpatients. Normal K+ and non- K+ unelevated profile groups were more similar to each other than either group was to a randomly selected inpatient control group of 50 Ss. Results generally support the contention of M. D. Gynther and P. J. Brilliant (see record 1969-00131-001) that applicability of empirical correlates of unelevated MMPI profiles should be determined in each clinical setting. (6 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)