Studies on some alkylamide surfactant gas hydrate anti-agglomerants

Low dosage hydrate inhibitors (LDHIs) are a recently developed hydrate control technology, which can be more cost-effective than traditional practices such as the use of thermodynamic inhibitors e.g., methanol and glycols. Two classes of LDHI called kinetic inhibitors (KHIs) and anti-agglomerants (AAs) are already being successfully used in the field. This paper describes efforts to develop new classes of AA surfactant with one or two alkylamide groups in the polar head. The goal was to find an AA that was as good as commercial quaternary AAs, which would be economically competitive and more environmentally friendly. The chemistry and environmental properties of the new surfactants are described along with experiments to determine their performance carried out in high-pressure sapphire cells and a wheel loop. The results indicate positive performance for some products but not as good as a commercial quaternary ammonium-based surfactant AA. The best surfactants had one or two carbonylpyrrolidine or isopropylamide groups in the head. The performance of the best AAs was found to be dependent on the hydrocarbon phase and salinity of the water phase.     

Blue-Green (~480 nm) versus Blue (~460 nm) Light for Newborn Phototherapy—Safety Considerations

We have previously shown that the phototherapy of hyperbilirubinemic neonates using blue-green LED light with a peak wavelength of ~478 nm is 31% more efficient for removing unconjugated bilirubin from circulation than blue LED light with a peak wavelength of ~452 nm. Based on these results, we recommended that the phototherapy of hyperbilirubinemic newborns be practiced with light of ~480 nm. Aim: Identify and discuss the most prominent potential changes that have been observed in the health effects of phototherapy using either blue fluorescent- or blue LED light and speculate on the expected effects of changing to blue-green LED light phototherapy. Search the phototherapy literature using the terms neonate, hyperbilirubinemia, and phototherapy in the PubMed and Embase databases. Transitioning from blue fluorescent light to blue-green LED light will expose neonates to less light in the 400–450 nm spectral range, potentially leading to less photo-oxidation and geno-/cytotoxicity, reduced risk of cancer, and decreased mortality in extremely low-birthweight neonates. The riboflavin level may decline, and the increased production and retention of bronze pigments may occur in predisposed neonates due to enhanced lumirubin formation. The production of pre-inflammatory cytokines may rise. Hemodynamic responses and transepidermal water loss are less likely to occur. The risk of hyperthermia may decrease with the use of blue-green LED light and the risk of hypothermia may increase. Parent–neonate attachment and breastfeeding will be positively affected because of the shortened duration of phototherapy. The latter may also lead to a significant reduction in the cost of phototherapy procedures as well as the hospitalization process.     

Single-mode and polarization-independent silicon-on-insulator waveguides with small cross section

The fabrication restrictions that must be imposed on the geometry of optical waveguides to make them behave as single-mode devices are well known for relatively large waveguides, with shallow etch depth. However, the restrictions for small waveguides (/spl sim/1 /spl mu/m or less in cross section) are not well understood. Furthermore, it is usually a requirement that these waveguides are polarization independent, which further complicates the issues. This paper reports on the simulations of the conditions for both single-mode behavior and polarization independence, for small and deeply etched silicon-on-insulator (SOI) waveguides. The aim is to satisfy both conditions simultaneously. The results show that at larger waveguide widths, waveguide etch depth has little effect on the mode birefringence because the transverse-electric (TE) mode (horizontal-polarized mode) is well confined under the rib region. However, at smaller rib widths, the etch depth has a large influence on birefringence. An approximate equation relating the rib-waveguide width and etch depth to obtain polarization-independent operation is derived. It is possible to achieve single-mode operation at both polarizations while maintaining polarization independence for each of the waveguide heights used in this paper but may be difficult for other dimensions. For example, a 1-/spl mu/m SOI rib waveguide with an etch depth of 0.64 /spl mu/m and rib width of 0.52 /spl mu/m is predicted to exhibit such characteristics.     

Outcome of open antireflux surgery as assessed in a Nordic multicentre prospective clinical trial. Nordic GORD-Study Group

OBJECTIVE: To evaluate the outcome of antireflux surgery in various hospitals in Scandinavian countries. DESIGN: Partly randomised controlled study, and partly open study. SETTING: Hospitals throughout Norway, Sweden, Denmark and Finland. SUBJECTS: 310 patients with chronic reflux disease and oesophagitis who were initially entered into a randomised controlled study of omeprazole and antireflux surgery. INTERVENTIONS: Total fundic wrap, partial fundoplication, or omeprazole. MAIN OUTCOME MEASURES: Control of symptoms at one year. RESULTS: 154 patients who had their symptoms of reflux completely controlled with omeprazole were initially randomised to have an open operation but 10 refused, leaving 144 for analysis. 34 patients who had only a partial response were also offered operation; 120/178 (68%) had a total fundic wrap, and 53 (30%) partial fundoplication. 6 patients had postoperative complications that required reoperation and 123 made a completely uneventful recovery. Reflux was controlled in most patients, and only 10 (6%) required further treatment with omeprazole. The outcome in those patients who only responded partially to omeprazole was similar to that in patients who had a complete response. CONCLUSION: The outcome of antireflux surgery throughout Norway, Sweden, Denmark, and Finland is good.     

Sex differences in investigatory and grooming behaviors of laboratory rats (Rattus norvegicus) following exposure to novelty.

Prior research suggested that during exposure to novel stimuli, rodent investigation and self-grooming behaviors may be sexually dimorphic and interact with ambient illumination. To test this notion we compared the behavior of adult male and female groups of Long-Evans hooded rats in normal room lighting (860 lx) and in very dim, red light (0.2 lx) following exposure to a novel juvenile conspecific. Illuminance level had little or no effect, but investigatory and subsequent self-grooming behaviors of males were substantially greater than those of females, and females engaged in greater ambulatory activity than did males. In a second experiment adult males and females were exposed to a novel inanimate object. No reliable sex differences were observed. We conclude that social novelty, as provided by exposure to a juvenile conspecific, stimulates greater investigation and postinvestigatory self-grooming than exposure to a novel inanimate object and that exposure to novel conspecifics presents a useful method for the investigation of sex differences, gonadal hormone effects, and interactions of hormones with neurotransmitter systems governing motor control systems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Primary leiomyosarcoma of the fallopian tube

Chronic renal failure occurs in about 20% of long-term survivors treated with bone marrow transplant (BMT) regimens that include total-body irradiation (TBI); this syndrome is called BMT nephropathy. In a previous study in a syngeneic rat BMT model it was shown that captopril (an inhibitor of angiotensin-converting enzyme) could be used to treat experimental BMT nephropathy. Current studies were designed to determine whether captopril could also be used to prevent BMT nephropathy. Rats received 14 to 18.5 Gy TBI in six fractions over 3 days followed by syngeneic BMT. Seven days before TBI half the rats were started on captopril (500 mg/liter in the drinking water). Blood urea nitrogen, ratios of urine protein to creatinine, serum creatinine, and blood pressure were used to assess renal function. In animals receiving TBI alone, BMT nephropathy developed 3 to 6 months after transplant. At 6 months after TBI, captopril-treated animals had lower systolic blood pressure and better-preserved renal function than animals receiving TBI alone, with dose-modifying factors of about 1.3. The captopril treatment had no effect on bone marrow ablation by TBI. Captopril appears to be safe and effective in the prophylaxis of BMT nephropathy.     

The eXogenous Kalman Filter (XKF)

It is well known that the time-varying Kalman Filter (KF) is globally exponentially stable and optimal in the sense of minimum variance under some conditions. However, nonlinear approximations such as the extended KF linearises the system about the estimated state trajectories, leading in general to loss of both global stability and optimality. Nonlinear observers tend to have strong, often global, stability properties. They are, however, often designed without optimality objectives considering the presence of unknown measurement errors and process disturbances. We study the cascade of a global nonlinear observer with the linearised KF, where the estimate from the nonlinear observer is an exogenous signal only used for generating a linearised model to the KF. It is shown that the two-stage nonlinear estimator inherits the global stability property of the nonlinear observer, and simulations indicate that local optimality properties similar to a perfectly linearised KF can be achieved. This two-stage estimator is called an eXogeneous KF (XKF).     

A passive output feedback controller with wave filter for marine vehicles

An output feedback controller with a wave filter for regulation of nonlinear marine vehicles is derived. Only measurements of position and attitude are needed. Asymptotic stability for the position and attitude around the desired values, and the velocity about zero is proven by applying Lyapunov stability analysis. Even though the wave filter in this paper has a notch filter structure, it is incorporated in the controller such that the system from the vehicle's velocity to the control input is passive. This is opposed to conventional notch filters which are usually designed separately from the controller itself, possibly complicating the stability analysis. Finally, a simulation study of a ship illustrates the design procedure of the controller. © 1998 John Wiley & Sons, Ltd.     

Maximizing industrial infrastructure efficiency in Iceland

As a consequence of the increasing aluminum production in Iceland, local processing of aluminum skimmings has become a feasible business opportunity. A recycling plant for this purpose was built in Helguvik on the Reykjanes peninsula in 2003. The case of the recycling plant reflects increased concern regarding environmental aspects of the industry. An interesting characteristic of this plant is the fact that it is run in the same facilities as a large fishmeal production installation. It is operated by the same personnel and uses—partly—the same equipment and infrastructure. This paper reviews the grounds for these decisions and the experience of this merger of a traditional fish melting industry and a more recent aluminum melting industry after 6 years of operation. The paper is written by the original entrepreneurs behind the company, who provide observations on how the aluminum industry in Iceland has evolved since the starting of Alur’s operation and what might be expected in the near future.