This study demonstrates how social network analysis, specifically ego-network analysis, can be used as a methodology to investigate the degrees of the isolation, insularity, and prestige of academic journals in a particular field in relation to other fields. Using the example of journals in public administration for illustrative purposes, we analyze the network of connections between journals in this field and the ones in two related fields: political science and business/management. Earlier studies found that the research in public administration was largely isolated from the three disciplines that were its foundations: law, management, and political science. Using ego-network analyses and ratio calculations from the Web of Science citation data, we found that the top journals of public administration were indeed relatively isolated in the years 2005, 2010, and 2015. Of the public administration journals, Public Administration Review (PAR) and the Journal of Public Administration Research and Theory (JPART) were increasingly more recognized (less isolated and became more prestigious) among the journals in other fields. This methodology can be applied to the journals in other fields to study the relations between fields, particularly the relative academic prestige of the fields, in terms of journal citations.
The effect of temperature on product formation during the sulphonation of indigo with concentrated sulphuric acid and 30 % fuming sulphuric acid was studied with the aid of high performance liquid chromatographic (HPLC) analysis. Trisulphoindigo was prepared by the sulphonation of indigo with concentrated sulphuric acid at 160°C. The di- and tetra-sulphoindigo side products formed during the reaction were removed by preparative HPLC to yield a product of high chromatographic purity. The trisulphoindigo content of the food dye FD & C Blue No. 2 and the purity of commercially available trisulphoindigo were determined by HPLC analysis. 相似文献
The cardiovascular effects of pulmonary exposure to engineered nanomaterials (ENM) are poorly understood, and the reproductive consequences are even less understood. Inflammation remains the most frequently explored mechanism of ENM toxicity. However, the key mediators and steps between lung exposure and uterine health remain to be fully defined. The purpose of this study was to determine the uterine inflammatory and vascular effects of pulmonary exposure to titanium dioxide nanoparticles (nano-TiO2). We hypothesized that pulmonary nano-TiO2 exposure initiates a Th2 inflammatory response mediated by Group II innate lymphoid cells (ILC2), which may be associated with an impairment in uterine microvascular reactivity.
Methods
Female, virgin, Sprague-Dawley rats (8–12 weeks) were exposed to 100 μg of nano-TiO2 via intratracheal instillation 24 h prior to microvascular assessments. Serial blood samples were obtained at 0, 1, 2 and 4 h post-exposure for multiplex cytokine analysis. ILC2 numbers in the lungs were determined. ILC2s were isolated and phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) levels were measured. Pressure myography was used to assess vascular reactivity of isolated radial arterioles.
Results
Pulmonary nano-TiO2 exposure was associated with an increase in IL-1ß, 4, 5 and 13 and TNF- α 4 h post-exposure, indicative of an innate Th2 inflammatory response. ILC2 numbers were significantly increased in lungs from exposed animals (1.66?±?0.19%) compared to controls (0.19?±?0.22%). Phosphorylation of the transactivation domain (Ser-468) of NF-κB in isolated ILC2 and IL-33 in lung epithelial cells were significantly increased (126.8?±?4.3% and 137?±?11% of controls respectively) by nano-TiO2 exposure. Lastly, radial endothelium-dependent arteriolar reactivity was significantly impaired (27?±?12%), while endothelium-independent dilation (7?±?14%) and α-adrenergic sensitivity (8?±?2%) were not altered compared to control levels. Treatment with an anti- IL-33 antibody (1 mg/kg) 30 min prior to nano-TiO2 exposure resulted in a significant improvement in endothelium-dependent dilation and a decreased level of IL-33 in both plasma and bronchoalveolar lavage fluid.
Conclusions
These results provide evidence that the uterine microvascular dysfunction that follows pulmonary ENM exposure may be initiated via activation of lung-resident ILC2 and subsequent systemic Th2-dependent inflammation.
This article proposes a bi‐criteria formulation to find the optimal location of light rapid transit stations in a network where demand is elastic and budget is constrained. Our model is composed of two competing objective functions seeking to maximize the total ridership and minimize the total budget allocated. In this research, demand is formulated using the random utility maximization method with variables including access time and travel time. The transit station location problem of this study is formulated using mixed integer programming and we propose a heuristic solution algorithm to solve large‐scale instances which is inspired by the problem context. The elastic demand is integrated with the optimization problem in an innovative way which facilitates the solution process. The performance of our model is evaluated on two test problems and we carry out its implementation on a real‐world instance. Due to the special shape of the Pareto front function, significant practical policy implications, in particular budget allocation, are discussed to emphasize the fact that the trade‐off between cost and benefit may result in large investments with little outcomes and vice versa. 相似文献
The availability of different forages varies across landscapes, but little is known about how proportional consumption of
different foods affects food intake and the use of landscapes. The relative amounts of nutrients and plant secondary metabolites
(PSM) consumed by herbivores may influence forage intake and animal fitness in landscapes dominated by plants with PSM. Our
objective was to determine if the relative availability of nutritious foods that contain PSM affected food preference and
intake by lambs. Lambs in three treatments (eight lambs/treatment) were offered two PSM-containing foods at different relative
availabilities: treatment 1—ad libitum terpene- and 100-g tannin-containing food, treatment 2—ad libitum tannin- and 100-g terpene-containing food, and treatment 3—ad libitum access to both tannin- and terpene-containing foods. We measured intake of individual foods and total intake of PSM-containing
foods during conditioning and a preference test, where animals were offered both PSM-containing foods ad libitum. When lambs were fed 100 g of the tannin-containing food, they ingested more terpene and total PSM (P < 0.05) than when both PSM were offered ad libitum, but limiting terpenes did not affect intake of tannin or total intake of PSM (P > 0.10). During preference tests, all groups preferred tannins over terpenes, but lambs in the treatment fed 100 g of tannin
had a higher preference for terpenes than did lambs in the other two treatments (P < 0.10). These results support the notion that the relative amounts of PSM consumed affects intake and preference for PSM-containing
foods by herbivores. 相似文献
The insufficient strategies to improve electronic transport, the poor intrinsic chemical activities, and limited active site densities are all factors inhibiting MXenes from their electrocatalytic applications in terms of hydrogen production. Herein, these limitations are overcome by tunable interfacial chemical doping with a nonmetallic electron donor, i.e., phosphorization through simple heat‐treatment with triphenyl phosphine (TPP) as a phosphorous source in 2D vanadium carbide MXene. Through this process, substitution, and/or doping of phosphorous occurs at the basal plane with controllable chemical compositions (3.83–4.84 at%). Density functional theory (DFT) calculations demonstrate that the P? C bonding shows the lowest surface formation energy (ΔGSurf) of 0.027 eV Å?2 and Gibbs free energy (ΔGH) of –0.02 eV, whereas others such as P‐oxide and P? V (phosphide) show highly positive ΔGH. The P3–V2CTx treated at 500 °C shows the highest concentration of P? C bonds, and exhibits the lowest onset overpotential of –28 mV, Tafel slope of 74 mV dec?1, and the smallest overpotential of ‐163 mV at 10 mA cm?2 in 0.5 m H2SO4. The first strategy for electrocatalytically accelerating hydrogen evolution activity of V2CTx MXene by simple interfacial doping will open the possibility of manipulating the catalytic performance of various MXenes. 相似文献
A consumer study was conducted to determine palatability ratings of beef tenderloin steaks from USDA Choice, USDA Select, and USDA Select with marbling scores from Slight 50 to 100 (USDA High Select) cooked to various degrees of doneness. Steaks were randomly assigned to 1 of 3 degree of doneness categories: very‐rare, medium‐rare, or well‐done. Consumers (N = 315) were screened for preference of degree of doneness and fed 4 samples of their preferred doneness (a warm‐up and one from each USDA quality grade treatment in a random order). Consumers evaluated steaks on an 8‐point verbally anchored hedonic scale for tenderness, juiciness, flavor, and overall like as well as rated steaks as acceptable or unacceptable for all palatability traits. Quality grade had no effect (P > 0.05) on consumer ratings for tenderness, juiciness, flavor, and overall like scores, with all traits averaging above a 7 (“like very much”) on the 8‐point scale. In addition, no differences (P > 0.05) were found in the percentage of samples rated as acceptable for all palatability traits, with more than 94% of samples rated acceptable for each trait in all quality grades evaluated. Steaks cooked to well‐done had lower (P < 0.05) juiciness scores than steaks cooked to very‐rare or medium‐rare and were rated lower for tenderness (P < 0.05) than steaks cooked to a very‐rare degree of doneness. Results indicate consumers were not able to detect differences in tenderness, juiciness, flavor, or overall like among beef tenderloin steaks from USDA Choice and Select quality grades. 相似文献
In this paper we formulate a network design model in which the traffic flows satisfy dynamic user equilibrium conditions for
a single destination. The model presented here incorporates the Cell Transmission Model (CTM); a traffic flow model capable
of capturing shockwaves and link spillovers. Comparisons are made between the properties of the Dynamic User equilibrium Network
Design Problem (DUE NDP) and an existing Dynamic System Optimal (DSO) NDP formulation. Both network design models have different
objective functions with similar constraint sets which are linear and convex. Numerical demonstrations are made on multiple
networks to demonstrate the efficacy of the model and demonstrate important differences between the DUE and DSO NDP approaches.
In addition, the flexibility of the approach is demonstrated by extending the formulation to account for demand uncertainty.
This is formulated as a stochastic programming problem and initial test results are demonstrated on test networks. It is observed
that not accounting for demand uncertainty explicitly, provides sub-optimal solution to the DUE NDP problem. 相似文献