The effectiveness of psychiatric treatment for HIV-infected patients

p-hydroxymethamphetamine (OHMAP) is one of the major metabolites of the widely abused drug methamphetamine (MAP). The demethylation of OHMAP to p-hydroxyamphetamine (OHAP) has been shown in vitro but has never been reported in vivo. The disposition kinetics as well as the metabolism of OHMAP was investigated employing a sensitive HPLC method which can separate the enantiomers of OHMAP and OHAP. Both conjugated and unconjugated forms of these compounds can be quantitated. Male Sprague-Dawley rats were given an iv bolus of racemic OHMAP (20 mg kg-1) and serum and urine samples were collected at selected times. The serum concentration-time data for OHMAP enantiomers could be described by a biexponential equation. The clearance of D-OHMAP (93.5 mL min-1 kg-1) was slightly, but statistically significantly, greater than that of the L-enantiomer (83.9 mL min-1 kg-1). The steady-state volumes of distribution of L- and D-OHMAP were (mean +/- SD) 3.15 +/- 0.84 and 4.23 +/- 1.76 L kg-1, respectively. No significant concentrations or amounts of OHAP enantiomers could be detected in any serum or urine sample. Rats excreted more unchanged L-OHMAP (34%) than D-OHMAP (29%). In contrast, more conjugated D-OHMAP (57%) was recovered compared to the conjugated L-OHMAP (52%). The results suggest that there is slight stereoselectivity in the disposition of OHMAP enantiomers. The N-demethylation product (OHAP) was not produced in vivo.     

Implicit and explicit memory for visual patterns.

The article reports an investigation of implicit and explicit memory for novel, visual patterns. Implicit memory was assessed by a speeded perception task, and explicit memory by a four-alternative, forced-choice recognition task. Tests were given either immediately after testing or 7 days later. The results suggest that a single exposure of a novel, nonverbal stimulus is sufficient to establish a representation in memory that is capable of supporting long-lived perceptual priming. In contrast, recognition memory showed significant loss over the same delay. Performance measures in the two tasks showed stochastic independence on the first trial after a single exposure to each pattern. Finally, a specific occurrence of a previously studied item could be retrieved from explicit memory but did not affect the accuracy of perception in the implicit memory test. The results extend the domain of experimental dissociations between explicit and implicit memory to include novel, nonverbal stimuli. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The line–motion illusion: Attention or impletion?

When a brief lateral cue precedes an instantaneously presented horizontal line, observers report a sensation of motion in the line propagating from the cued end toward the uncued end. This illusion has been described as a measure of the facilitatory effects of a visual attention gradient (O. Hikosaka, S. Miyauchi, & S. Shimojo, 1993a). Evidence in the present study favors, instead, an account in which the illusion is the result of an impletion process that fills in interpolated events after the cue and the line are linked as successive states of a single object in apparent motion. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

There are two types of psychometric function: A theory of cue combination in the processing of complex stimuli with implications for categorical perception.

Psychometric functions are customarily fitted using normal distribution functions. However, categorical perception identification tasks give functions that are more sigmoid than the normal distribution (M. Treisman, A. Faulkner, P. L. N. Naish, & B. S. Rosner, see record 1995-42700-001). This can be explained by a theory of discrimination, cue combination theory (CCT), presented here. This theory assumes that complex stimuli (e.g., speech sounds) are composed of components or cues that vary in informativeness. The decision mechanisms sample individual cue dimensions and combine the information from each. The model generates a normal psychometric function if all cues sampled are informative. If not, the function becomes more sigmoid. CCT offers accounts of discrimination (categorical and continuous) and sensory reaction times, adaptation, sequential effects, contextual effects, trading relations, speed and accuracy, perceptual learning, and the separable-integral distinction. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Perception of Objects in Natural Scenes: Is It Really Attention Free?

Studies have suggested attention-free semantic processing of natural scenes in which concurrent tasks leave category detection unimpaired (e.g., F. Li, R. VanRullen, C. Koch, & P. Perona, 2002). Could this ability reflect detection of disjunctive feature sets rather than high-level binding? Participants detected an animal target in a rapid serial visual presentation (RSVP) sequence and then reported its identity and location. They frequently failed to identify or to localize targets that they had correctly detected, suggesting that detection was based only on partial processing. Detection of targets was considerably worse in sequences that also contained humans, presumably because of shared features. When 2 targets were presented in RSVP, a prolonged attentional blink appeared that was almost eliminated when both targets were detected without being identified. The results suggest rapid feature analysis mediating detection, followed by attention-demanding binding for identification and localization. (PsycINFO Database Record (c) 2010 APA, all rights reserved)