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111.
The tableting process causes a temperature increase due to dissipation of energy. Therefore, with time the temperature of the tablets and the tablet press increases. Depending on the calculated tablet temperature, this temperature increase is discussed for different compression forces and lubricant concentrations. Two different measurement techniques are presented and compared. 相似文献
112.
Tagging Glycoproteins with Fluorescently Labeled GDP‐Fucoses by Using α1,3‐Fucosyltransferases 下载免费PDF全文
Dr. Katrin Seelhorst Katharina Pahnke Prof. Dr. Chris Meier Prof. Dr. Ulrich Hahn 《Chembiochem : a European journal of chemical biology》2015,16(13):1919-1924
Fucose‐containing glycans mediate a variety of biological processes, but there is little information on reaction processes and mechanisms mediated by fucosyltransferases. We recently reported on fluorescently labeled GDP‐β‐L ‐fucose‐ATTO 550, which enabled monitoring of α1,3‐fucosyltransferase activity. Here we present an extension to the previously described results, based on the synthesis of a fluorescein‐isothiocyanate (FITC)‐labeled and two carboxyfluorescein‐labeled (FAM‐labeled) NDP‐β‐L ‐fucose derivatives, and applied all four compounds in labeling of different glycoproteins with the aid of four different fucosyltransferases. The labeling processes were analyzed by in‐gel fluorescence and fluorescence polarization measurements. Comparison with the ATTO‐labeled sugar revealed that the FITC‐labeled fucose was the best of these substrates, and that the bacterial enzyme HP‐FucT tolerated the fluorescent substrates better than human fucosyltransferases. 相似文献
113.
Lena Arnold Gauthier Averlant Dr. Stefan Marx Mathias Weickert Ulrich Müller Jonathan Mertel Carsten Horch Mikulas Peksa Frank Stallmach 《化学,工程师,技术》2013,85(11):1726-1733
With the increasing demand for alternative fuels the storage of natural gas (NG) in adsorbents like metal organic frameworks (MOFs) will become more important. In order to use MOFs as storage media in fuel delivery systems, the optimization of mass and energy transfer of the system is crucial. For rapid NG filling of a tank, molecules need to reach the adsorption sites within a reasonable time while the heat of adsorption should be dissipated to the environment. In this article, mass transfer in shaped bodies of MOFs was determined by permeability measurements and pulsed field gradient (PFG) NMR spectroscopy. The heat dissipation was also experimentally measured and both data sets were used to set up a theoretical density function theory model to predict the behavior of MOFs for NG storage. 相似文献
114.
Well-formed carbon nanocones at the ends of micrometer-diameter carbon fibers (CFs) were fashioned into functional tips for scanning tunneling microscopy (STM) and miniaturized voltammetric sensors. Sharpening of single graphite filaments was achieved by simple DC electrochemical etching in 0.1 N NaOH. Operated as STM tips, pointed CFs resolved in air the contour and surface morphology of a nanoscopic Au line pattern and imaged in vacuum a Si (1 1 1) surface with clear atomic resolution. Subjecting already etched CFs to tip-sparing insulation with electrodeposited paint produced conical carbon ultramicroelectrodes (UMEs) with effective radii down to about 900 nm. Comparative cyclic voltammetry trials in alkaline, neutral and acidic solutions showed that the conical carbon UME’s had a wider practical potential window for electroanalytic applications than, for instance, Pt disk UMEs. The CF-based conical sensors described here are exceptionally easy to make with simple laboratory equipment and perform well in STM topography imaging and voltammetry. The inherent simplicity of sensor production widens the field of potential users, and offers clear advantages over existing types of UMEs, in particular those based on carbon nanotubes, which are especially hard to handle in an optical microscope setting. 相似文献
115.
Nitrate radicals are being recognized as key intermediates in a growing list of important chemical processes in the atmosphere. Here, the role of nitrate radicals (NO3) in tropospheric chemistry is discussed, with special emphasis on results from field measurements, most of which have been made by differential optical absorption spectroscopy (DOAS), with matrix-isolation electron spin resonance being an alternative technique. Nitrate radicals were observed in the atmosphere at peak mixing ratios of 350 ppt. Long-term observation of NO3 shows that 24-h averages in rural air masses are closer to a few ppt. Nevertheless, the NO3 radical plays an important role in the non-photochemical conversion of NOx to HNO3. Also, NO3 is a strong oxidizing agent and initiates the night-time removal of atmospheric trace species such as olefins, aromatic hydrocarbons, and organic sulfur compounds. Finally, night-time peroxy radical production and release of reactive halogen species from sea salt aerosol might be initiated by NO3 reactions. 相似文献
116.
Mach UR Hackling AE Perachon S Ferry S Wermuth CG Schwartz JC Sokoloff P Stark H 《Chembiochem : a European journal of chemical biology》2004,5(4):508-518
Based on N-alkylated 1,2,3,4-tetrahydroisoquinoline derivatives, which are structurally related to the partial agonist BP 897, a series of novel, selective dopamine D3 receptor antagonists has been synthesised. Derivatisation included changes in the arylamide moiety and the tetrahydroisoquinoline substructure leading to compounds with markedly improved selectivities and affinities in the low nanomolar concentration range. From the 55 structures presented here, (E)-3-(4-iodophenyl)-N-(4-(1,2,3,4-tetrahydroisoquinolin-2-yl)butyl)acrylamide (51) has high affinity (Ki(hD3)=12 nM) and a 123-fold preference for the D3 receptor relative to the D2 receptor subtype. Its pharmacological profile offers the prospect of a novel radioligand as a tool for various dopamine D3-receptor-related in vitro and in vivo investigations. 相似文献
117.
Gerd Scheying Ingrid Wührl Ulrich Eisele Ralf Riedel 《Journal of the American Ceramic Society》2004,87(3):358-364
Two ultrafine, undoped ZrO2 powders with median primary particle sizes of 9 and 25 nm were used to prepare ceramic suspensions for thermoplastic extrusion. The organic vehicle consisted of an industrial-grade poly(ethylene- co -vinyl acetate) (EVA) or polyethylene (PE-HD) and decanoic acid as a dispersing agent. The powder volume loadings achieved were 44% and 52% by volume for the two powders, respectively. The amount of dispersant needed was calculated from a new model based on available chemisorption sites on the powder surface. Mixing and extrusion were conducted using a conventional modular plastic processing unit. Green bodies were dewaxed up to 450°C in an inert atmosphere and sintered to full density in air at 1060° and 1100°C, respectively. Analysis of the ceramic phase content and the microstructure of the bodies is presented. 相似文献
118.
Important environmental parameters in arctic periglacial landscapes (i.e. permafrost temperature, active-layer depth, soil moisture, precipitation, vegetation cover) will very likely change in a warming climate. The thawing of permafrost, especially, might cause massive landscape changes due to thermokarst and an enhanced release of greenhouse gasses from the large amounts of carbon stored in frozen deposits, resulting in positive climate-warming feedback. For the identification, mapping, and quantification of such changes on various scales up to the entire circum-Arctic, remote sensing and spatial data analysis are essential tools. In this study an extensive field-work dataset including spectral surface properties, vegetation, soils, and geomorphology was acquired in the largest Arctic delta formed by a single river, the Siberian Lena River Delta. A portable field spectrometer (ASD FieldSpec Pro FR®) was used for spectral surveys of terrain surfaces, and optical satellite data (Landsat Enhanced Thematic Mapper (ETM+), CHRIS-Proba) were used for the characterization, manual mapping, and automatic classification of typical periglacial land-cover units in the Lena Delta. Qualitative data from soils, vegetation, soil moisture, and relief units were correlated with the field-spectral data and catalogued for a wide variety of surface types. The wide range of micro- and meso-scale variations of periglacial surface features in the delta results in distinctive spectral characteristics for different land-cover units. The three main delta terraces could also be spectrally separated and characterized. The present dataset provides a basis for further spectral data acquisitions in the Lena Delta and for comparisons with periglacial surfaces from other regions. 相似文献
119.
120.
Patrick J. Riss Dr. Fabian Debus Dr. René Hummerich Ulrich Schmidt Dr. Patrick Schloss Dr. Hartmut Lueddens Dr. Frank Roesch Dr. 《ChemMedChem》2009,4(9):1480-1487
N‐4‐Fluorobut‐2‐yn‐1‐yl‐2β‐carbomethoxy‐3β‐phenyltropane (PR04.MZ) has been developed as dopamine transporter (DAT) ligand for molecular imaging. It contains a terminally fluorinated, conformationally constrained nitrogen substituent that is well suited for the introduction of fluorine‐18. The present report describes the pharmacological characterisation of [18F]PR04.MZ. The ligand shows an IC50 value of 2 nM against human DAT, whereas the IC50 value against human serotonin transporter and human noradrenalin transporter are lower (110 nM and 22 nM , respectively). Furthermore, its ex vivo organ distribution, its binding profile in the rat brain and reversibility of binding were examined. A μPET study illuminates a fast kinetic profile and specific binding to rat DAT. 相似文献