An experimental study of the possibilities of using pentoxifylline for the prevention of cancer at different sites

Three models of cancerogenesis were used to test the anti-cancerogenic effects of pentoxiphylline. In female rats, breast adenocarcinoma was induced by intramammary injections of N-methyl-N-nitrosourea (MNU) or colonic and rectal adenocarcinomas by intrarectal instillations of MNU. In female mice, squamous cell carcinomas of the cervix uteri and vagina were induced by intravaginal applications of 7,12-dimethyl-benz(a) anthracene (DMBA). Pentoxifylline was given with drinking water at a concentration of 500 mg/l long at the stage of carcinogenesis promotion/progression. Pentoxifylline exerted a strong inhibitory effect on the development of mammary tumors and a moderate inhibitory effect on the development of colonic and rectal tumors induced by MNU in rats. However, the drug did not affect the development of cervical and vaginal tumors caused by DMBA in mice.     

Perfection of methodical approaches to designing vaccines against tick-borne encephalitis

Nine female patients with a urethral diverticulum were admitted to our center over a six period: The clinical symptomatology was not specific. The diagnosis has been performed by voiding and retrograde cysto-uretrogram. The surgical treatment consisted in the excision of the diverticula, with the patient in the supine position. No perioperative morbidity was observed.     

A model of reduction of oxidation-enhanced diffusion in heavily doped Si layers

A model of reduction of oxidation-enhanced diffusion (OED) in heavily doped Si layers via bulk recombination of self-interstitials at centers associated with the dopant is suggested. The allowance made for the recombination of excess self-interstitials, which are generated upon thermal oxidation, allows one to describe the dependence of OED reduction on the doping level. The experimental data on the OED of B and P impurities in uniformly doped Si layers are analyzed. From the analysis, the recombination-rate constants are determined and capture radii are estimated for various variants of interaction of excess self-interstitials with impurity atoms and impurity-vacancy pairs.     

The role of dopamine in the mechanism of the regulation of the digestive-transport functions of the enterocyte membrane during stress

The L-DOPA and sulpiridinum effects on the enzymatic transporting function of the enterocytes' membrane, were studied in rats under stress. The L-DOPA was shown to hinder the absorption rate of glucose, whereas sulpiridinum was shown to suppress the main enzymes excepting snerase and alkaline phosphatase, to increase the monomeric and hydrolysate glucose transport. The L-DOPA seems to play a modifying role in the regulation and integration of the digestive-transporting function of the enterocytes' membrane in rats under stress.     

The Problem of Estimating the Uncertainty of the Fixed Point Temperature Due to the Presence of Impurities

The main problems in estimating the uncertainty due to the presence of impurities in the material: the absence in the documents of a unique definition of the quantity being measured – the fixed point temperature, the lack of agreed methods of realizing the fixed points and the insufficient justification of the equations used for the estimate, are analyzed. The results of a measurement of the melting point of gallium are presented, which differ in the conditions in which they were realized – with one and two liquid-solid interfaces and different solidification conditions, are presented. The reasons for the considerable difference between the values of the temperatures obtained in these experiments are discussed.     

The use of interference currents and iodobromine baths in the therapy of patients with chronic nonobstructive pyelonephritis

30 patients were exposed to interference currents (IC) alone (group 1) versus 34 patients treated with IC plus iodobromine baths (group 2). After IC action on the region of the kidney projection patients of group 1 experienced positive changes in cellular and humoral immunity providing an antiinflammatory effect. In group 2, the improvement was seen in renal and urinary functions, 24-h urinary excretion of oxalates and calcium diminished. Interference current proved beneficial in chronic pyelonephritis patients with latent inflammation. The combined therapy was effective in patients at high risk of lithogenesis.     

The intra-aortic antibacterial therapy of wounded patients with gunshot meningoencephalitis

The original decision of permanent introduction of antibacterial means to tissues of brain at gunshot meningoencephalitis is offered. For antibacterial therapy the intra-aortal catheter with diameter of 2,5 mm (through a.femoralis) was introduced. After washing the catheter by solution of crystalloid with heparin the various combinations of preparations in 5% solution of glucose were introduced: cephalosporin--8 g/day; hentamicin and brumacilin--240 mg/day accordingly, amicacin--1500 mg/day. Speed of introduction--20-50 mg/h, total volume--500 ml. The catheter was in aorta not more than 10 days, maximum--14 days. A described technique was applied in Burdenko Main Military Clinical Hospital on 34 wounded in head. At computer tomography of brain of all wounded intracranially the splinters and bullets were revealed, clinically--meningoencephalitis. Foreign bodies have been extracted after cupping of clinical and laboratory signs of meningoencephalitis. The authors consider, that the technique is effective not only at wounds of brain, but also at suppurative meningoencephalitis of other etiology.