Informationstagung Mikroelektronik 1999

Ohne Zusammenfassung     

Hydroxyl radical-induced hydrogen/deuterium exchange in amino acid carbon-hydrogen bonds

BB rats are used as models of autoimmune human IDDM. Genetic control of IDDM in both species is complex, including both major histocompatibility complex (MHC)-linked and non-MHC-linked genes. DP-BB rats develop IDDM spontaneously. Expression of disease in these animals requires homozygosity at the lyp locus, which causes lymphopenia. All genetic analyses of BB rat diabetes to date have backcrossed to the DP-BB strain or used (DP-BB x non-BB)F2 animals to ensure that a fraction of progeny are homozygous for lyp. Here we report the analysis of a backcross of the DP-BB rat to the histocompatible WF rat. Neither WF nor (WF x DP-BB)F1 animals develop spontaneous IDDM. However, 95% of (WF x DP-BB)F1 rats and a fraction of (WF x DP-BB) x WF backcross animals readily develop IDDM after treatment with polyinosinic:polycytidylic acid and a cytotoxic anti-RT6.1 monoclonal antibody. Using simple sequence length polymorphism analysis, we have mapped loci on chromosomes 4 and 13 that show significant linkage to IDDM expression and insulitis. The susceptibility locus on chromosome 4 is linked to, but not identical to, lyp. We propose a disease model for the BB rat that requires 1) the RT1u MHC haplotype for disease susceptibility, 2) a new locus on chromosome 4 for disease initiation (as measured by insulitis), 3) a new locus on chromosome 13 for disease progression in response to environmental perturbation, and 4) lyp for spontaneous expression of disease.     

Ein schnell messendes Laser-Speckle-Extensometer zur Bestimmung von statischen und dynamischen Materialparametern

In order to increase the measurement rate of so far in use laser straining sensors an absolutely new type of sensors has been developed. These sensors are based on Fourier optical data pre-processing. In this paper advantages and disadvantages of these Fourier optical sensors are discussed.     

Development and experimental verification of a method for assessment of consistency of the thermodynamic and structural properties of binary coolants based on systems of alkali metals

The construction of correlation function of concentration fluctuations S _cc (0) = f(T, x _i ) is used to validate the criterion of assessment of the internal consistency of the thermodynamic and structural properties of liquid-metal alloys, as well as of the reliability of experimental data on the Gibbs energy of solution formation ΔG, methods of their approximation, and theoretical models which reproduce the behavior of ΔG. The method is verified for the Cs-Na, K-Na, and Cs-K systems of alkali metals using the data of thermodynamic experiment in determining the Gibbs energy of formation of liquid-metal solution ΔG which is the basis for construction of the function S _cc (0). The data on statistical structure factor S(0) uniquely related to function S _cc (0) are obtained using the results (available in the literature) of experiments in X-ray and neutron spectroscopy, including data on diffraction and small-angle inelastic scattering.     

Synthesis and Anti-Proliferative Activity of Novel Quinolin-8-ol Derivatives

Through the coupling of substituted benzaldehydes with 8-hydroxy 5-amino methyl quinoline scaffold, a series of new derivatives has been synthesized. In vitro growth inhibitory effects on cancer cell line model have been evaluated. Discussion on the chemical reactivity of these new polycyclic aromatic analogs to generate alkylating species led to the hypothesis that the presence of an imine moiety impedes the formation of quinone methide intermediate and consequently abolishes in part their antiproliferative activity.