Persönliches

Ohne Zusammenfassung     

Koordinatenmesstechnik für biomedizinische Anwendungen

The importance of computer aided measurement techniques as a means of controlling industrial manufacturing and testing technical products with high accuracy is increasing ever more with the general goal of improving the quality of all kinds of products. This development started about twenty years ago and is still improving. There is also rapid development in biomedical technique and this demands the application of modern computerized measurement techniques and measuring devices. Especially computer aided co-ordinate metrology can be applied as a very important and universal tool for solving complex measuring tasks for workpiece metrology, to evaluate the measuring results to give the basis for the improvement and optimization of future work in the biomedical technique.     

38. Generalversammlung von CENELEC

Ohne Zusammenfassung     

Immune system function in patients with acute pyelonephritis

In the process of batch cultivation the strains under study are capable of prolonged growth at low temperature in rich and poor nutrient media (with the term of observation equal to 4 months), while at a temperature of 37 degrees C microbial populations quickly die (in 8-35 days). In the absence of compounds containing carbon, hydrogen and nitrogen in the nutrient medium, Listeria can proliferate under such conditions. As established with the use of gas chromatography and the radioisotopic method, they can uptake carbon dioxide, hydrogen and nitrogen from the air gas mixture, using carbon of the first gas for the synthesis of the main biopolymers (proteins, lipids, carbohydrates, DNA and RNA) and the second one as the source of energy. During the cultivation of Listeria at low temperature in poor nutrient media (soil microecosystems, synthetic mineral media) they are capable of preserving and under favorable conditions also increasing their virulence. Its increase is facilitated by capsule formation, mobility, chemotaxis, adhesion and invasion enhancing under such conditions.     

Nichtlineare Signalverarbeitung für die Sprachkommunikation

This paper provides an elementary introduction to problems and methods of nonlinear signal processing and presents on overview of recent developments in this field. An important topic is the modeling and processing of one-dimensional signals as exemplified in simple voice communication systems. The interplay and integration of deterministic and nondeterministic approaches is illustrated with recent research findings.     

Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi

Hyperresponsiveness of airway smooth muscle to allergens and environmental factors has long been associated with the pathophysiology of asthma. Tryptase, a serine protease of lung mast cells, has been implicated as one of the mediators involved in the induction of hyperresponsiveness. As a consequence, tryptase inhibitors have become the subject of study as potential novel therapeutic agents for asthma. Secretory leukocyte protease inhibitor (SLPI) is a naturally occurring protein of human airways which exhibits anti-tryptase activity. To assess the potential therapeutic utility of SLPI in asthma, its effects were evaluated using in vitro and ex vivo models of airway hyperresponsiveness and compared with the effects of the small molecule tryptase inhibitor APC-366. Our results demonstrate that SLPI inhibits tryptase-mediated hyperresponsiveness in vitro and attenuates the hyperresponsiveness observed in airway smooth muscle from antigen-sensitized animals subjected to antigen exposure. The small molecule tryptase inhibitor APC-366 has a similar inhibitory effect. Thus, tryptase appears to be a significant contributor to the development of hyperresponsiveness in these models. To the extent that tryptase contributes to the development and progression of asthma, SLPI may possess therapeutic potential in this disease setting.