The relationship of the restriction fragment length polymorphism of the apo-B gene to the blood lipid spectrum in patients with ischemic heart disease

Restriction fragment length polymorphism of the apo-B gene at the Xbal restriction site was detected. The association between RFLP of the apo-B gene and the level of lipid metabolism indices was revealed. The levels of total cholesterol LDLP CH and atherogenicity coefficient were significantly higher in homozygotes with this restriction site (X2X2) than in homozygotes X1X1 and heterozygotes.     

Thermodynamics of Superfluidity

A new superfluid specific additive integral of motion is found. This facilitates investigation of the general thermodynamic equilibrium conditions of a superfluid. The analysis is performed in an extended space of thermodynamic variables containing (along with the usual thermodynamic coordinates such as pressure and temperature) superfluid velocity and momentum density. The equilibrium stability conditions lead to thermodynamic inequalities which replace the Landau superfluidity criterion at finite temperatures.     

Energy-dependent phase-shift analysis of 2H+4He scattering in the energy range 0.87

VM Krasnopol''sky  VI Kukulin  EV Kuznetsova  J Horáek  NM Queen 《Canadian Metallurgical Quarterly》1991,43(2):822-834

Relationship between the binding sites for an alpha-conotoxin and snake venom neurotoxins in the nicotinic acetylcholine receptor from Torpedo californica

Photoinduced cross-links between the iodinated Lys26-p-azidobenzoyl derivative of neurotoxin II from Naja naja oxiana cobra venom and nicotinic acetylcholine receptor from Torpedo californica (AChR) have been studied in the presence of alpha-conotoxin GI from the marine snail C. geographus. Preincubation of the AChR-enriched membranes with increasing concentrations of alpha-conotoxin GI protects first the gamma subunit from photolabelling and then the delta subunit, the IC50 values being 0.76 and 5.01 microM, respectively. The results obtained, in view of the relevant data in literature, demonstrate that the (alpha + gamma) site, which is the high affinity site for d-tubocurarine, has also a higher affinity for an alpha-conotoxin than the (alpha + delta) containing site. The latter has a somewhat higher affinity than the (alpha + gamma) site towards some naturally occurring snake venom alpha-neurotoxins or their derivatives.