A comparative study of carboxylesterase in the white mouse and in the caterpillar of the cotton bollworm Heliothes armigera

Studies have been made on enzymic hydrolysis of p-nitrophenylacetate (p-NPhAc), n-nitrophenylbutyrate (p-NPhBu) and indophenylacetate (IPhAc) by carboxylesterase (CE) from mouse blood plasma and liver as well as from caterpillar of the cotton worm haemolymph, intestine and fat body. Different KM and V max values were obtained for CE from these sources. The highest specific activity of CE from mouse liver and caterpillar intestine and fat body was observed with p-NPhBu. p-NPhAc is the best substrate for CE from mouse blood serum and caterpillar haemolymph. Carboxylesterases from mouse and caterpillar differed in their sensitivity to armine and paraoxone by 1-2 orders depending on the substrate used. Species and tissue differences in the kinetics of CE-catalyzed reactions with different substrates and inhibitors were revealed.     

Ophthalmic tone of myopic eyes: statistical evaluation and role in formation of acquired myopia

The author summarizes the results of many-year profound statistical analysis of ophthalmic tone in myopic patients. Intraocular pressure (IOP) of myopic eyes in patients aged 10 to 62 years and refraction from 0.5 to -24.0 diopters was measured in 1220 eyes by the same type of Goldman's tonometer. Detailed distribution of IOP for age and refraction factor is presented. IOP has been studied in emmetropia, stable and progressive myopia, and in paired anisometropic eyes. The author emphasizes that myopia progresses at various levels of ophthalmic tone, whose increase is mainly functional and reversible, and is caused by organic changes in the anterior chamber angle in only 7% of cases. The author claims that IOP is an important characteristic of a myopic eye and is to be taken into consideration when prescribing pathogenetic therapy for progressive myopia.     

The emergence of silent myocardial ischemia as the manifestation of the nitrate withdrawal syndrome in patients with ischemic heart disease

A patient is described, who was examined 1 year after surgery for mandibular cyst diagnosed as radicular near the !5 tooth and for plasty of the secondary osseous cavity with hydroxyapatite granulate. X-Ray examination revealed a cystic cavity near the roots of teeth !234. Histologic examination of tissue fragments and the remainder of hydroxyapatite granulate, obtained by cystectomy, helped diagnose a primordial cyst. Intensive bone regeneration was observed at the site of hydroxyapatite granule accumulation and fusion of the new bone with the granules to form a solid osseogranular complex. The authors recommend hydroxyapatite ceramic granules for surgical treatment of minor and medium bone defects and for corrective bone plasty.